Novel treatments for acute myeloid leukemia #FIMM_UH

Joined October 2021
5 Photos and videos
Kontro Lab retweeted
This paper reports that authors identify molecular patterns linked to primary resistance to VEN–HMA therapy, including a higher BCL‑XL/BCL‑2 ratio and frequent TP53 mutations. These findings point to potential therapeutic strategies worth exploring Read more in depth 👉bit.ly/3Lllpo9
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Our latest @Hemasphere_EHA study from @FIMM_UH defines key signatures of #venetoclax hypomethylating agent #resistance in #AML and highlights strategies for targeting resistant disease. Read more: doi.org/10.1002/hem3.70282
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Kontro Lab retweeted
Data presented at #ESMO25 by Dr Mika Kontro on the Macrophage reprogrammer #bexmarilimab plus azacitidine in myelodysplastic syndrome (BEXMAB) @myESMO @OncoAlert @Daver_Leukemia @Dr_AmerZeidan
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New findings from our VenEx trial in #AML: venetoclax resistance linked to altered apoptosis & PRAME overexpression. Exploring PRAME-targeted immunotherapy apoptosis modulators. Grateful for Jane and Aatos Erkko Foundation support to advance this research. #JAES
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1/4 Capillary Sampling Enables Venetoclax Concentration Measurement in Acute Myeloid Leukaemia Within Academic Multicentre Trial New study by @LabKontro and colleagues – study highlights 👇
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25 Jan 2025
Ex vivo venetoclax sensitivity identified treatment responders and correlated with improved outcomes and prolonged survival. Groundbreaking results from the VenEx trial with the Finnish AML Group, @helsinkiuni and @FIMM_UH published now in @BloodJournal
VenEx trial showed that ex vivo drug sensitivity is beneficial for selecting patients with R/R or sAML for venetoclax-azacitidine therapy. ow.ly/XpL350UMeJB #clinicaltrialsandobservations #myeloidneoplasia
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Kontro Lab retweeted
Drug sensitivity testing on leukemia cells can predict how patients with acute myeloid leukemia (AML) will respond to a new combination therapy. New @LabKontro results allow treatments to be tailored to those who are most likely to benefit. 📰@HUS_fi: hus.fi/en/newsroom/drug-sens…
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Kontro Lab retweeted
Leukemiasolujen lääkeherkkyystestauksella voidaan ennustaa akuuttia myelooista leukemiaa sairastavien potilaiden hoitovaste uudelle lääkeyhdistelmälle. @LabKontro tulokset mahdollistavat hoidon kohdentamisen siitä eniten hyötyville potilaille. 📰@HUS_fi: hus.fi/ajankohtaista/laakehe…
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12 Dec 2023
Dr. Mika Kontro from @KontroLab discussed the latest advances in functional screening during the Multi-Omics Driven Precision Hematology Scientific Symposia at #ASH23. The VenEx trial indicates the efficacy of ex vivo venetoclax testing for predicting VEN AZA responses in AML.
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Kontro Lab retweeted
Meet our K. Albin Johansson Cancer Researcher @hkuusanm. Heikki has a versatile background in translational laboratory studies and focuses now on novel treatments for acute myeloid leukemia in @LabKontro. Read more 👇syopainstituutti.com/researc…
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Kontro Lab retweeted
A clinical trial performed in Finland has shown that a drug sensitivity test performed on patient's own cells in laboratory conditions predicts patient's response to a new effective leukemia drug, venetoclax. The study was led by Mika Kontro & @hkuusanm. helsinki.fi/en/hilife-helsin…
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Kontro Lab retweeted
1/ Excited to share our study with @ollidufva suggesting venetoclax resistance and BCL-XL dependence in erythroid/megakaryoblastic AML @BloodJournal doi.org/10.1182/blood.202101…
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16 Dec 2022
Our newest paper "Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia" is now published and accessible @Haematologica haematologica.org/article/vi…
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Kontro Lab retweeted
12 Dec 2022
Ex vivo venetoclax sensitivity predicts responses in both de novo and s/R/R AML patients @LabKontro #ASH22
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12 Dec 2022
Excellent talk by @josephsaad95 on NAMPT inhibitors in AML with monosomy 7/del(7q) yesterday at #ASH22!
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12 Dec 2021
Ex vivo drug sensitivity testing predicts venetoclax azacitidine treatment responses in AML. VenEx trial interim results presented at #ASH21
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