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Reginato Lab @LabReginato

Cancer biology lab @drexelmedicine focused on how signaling pathways regulate metabolic reprogramming in cancer cells.

Joined January 2020
  • Tweets 153
  • Following 700
  • Followers 628
47 Photos and videos
ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis aacrjournals.org/cancerres/a…

ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis

AbstractBrain metastasis in patients with breast cancer represents a terminal disease stage, with a median survival typically measured in months. Tumors that colonize the brain must adapt to its...

aacrjournals.org
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Happy to share recent work from our lab. ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis aacrjournals.org/cancerres/a…

ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis

AbstractBrain metastasis in patients with breast cancer represents a terminal disease stage, with a median survival typically measured in months. Tumors that colonize the brain must adapt to its...

aacrjournals.org
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Happy to share new Spotlight Review in @TrendsCellBio New job for an old tool: PI3Kβ phosphorylates OGT to regulate acetyl-C... sciencedirect.com/science/ar…
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Happy to share new publication on the role of OGT in regulating breast cancer stem cells led by former Biochemistry PhD student Giang Le Ming @GiangLeMinh2 and collaborator Lauren Ball at @MUSC_COM mdpi.com/3216500 #mdpicells via @Cells_MDPI

GATAD2B O-GlcNAcylation Regulates Breast Cancer Stem-like Potential and Drug Resistance

The growth of breast tumors is driven and controlled by a subpopulation of cancer cells resembling adult stem cells, which are called cancer stem-like cells (CSCs). In breast cancer, the function and...

mdpi.com
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Excited to share work started by Lorela Ciraku @loriciraku and completed by Emily Esquea @esqueaemily & Riley Young @_riley_young_ @DrexelMcbg & collaborators ACSS2 regulates ferroptosis in an E2F1-dependent manner in breast cancer brain metastatic cells biorxiv.org/content/10.1101/…
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Drexel @DrexelMCBG @Drexelmed PhD student Riley Young @_riley_young_ presented part of her thesis research as a short talk at @CSHL August 2024 Mechanisms and Models of Cancer Conference in Cold Spring Harbor, NY
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Congratulation to🥳Dr. Emily Esquea @esqueaemily who defended her PhD thesis last week #proudpi 🏆@drexelmcbg @Drexel_med_grad @DrexelMedicine
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Reginato Lab retweeted
DrexelMCBG@DrexelMcbg
17 May 2024
Big congrats to Emily 🎉 🎉 🎉 GRADUATE COLLEGE RESEARCH EXCELLENCE AWARDS - Expanding the Impact of Research 🧬 🧬 🧬 drexel.edu/graduatecollege/n… Emily Esquea, PhD Candidate Drexel @DrexelMcbg Program Mentor: Dr. Mauricio Reginato @LabReginato @DrexelBiochem @DrexelMedicine
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Excited to share this new work by excellent graduate students @esqueaemily @loriciraku @_riley_young_ @DrexelMcbg @DrexelMedicine with collaborators @NickiSimone4 @mzspectrum frontiersin.org/journals/pha…

Frontiers | Selective and brain-penetrant ACSS2 inhibitors target breast cancer brain metastatic...

Breast cancer brain metastasis (BCBM) typically results in an end-stage diagnosis and is hindered by a lack of brain-penetrant drugs. Tumors in the brain rel...

frontiersin.org
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Reginato Lab retweeted
DrexelMCBG@DrexelMcbg
10 May 2024
Thesis Defense 🧬🧬🧬 Emily Esquea @esqueaemily @DrexelMcbg PhD Candidate Friday, June 7, 2024, 10:00 a.m. NCB, Geary A Targeting Metabolic Vulnerabilities in Breast Cancer Brain Metastatic Cells Mentor: Dr. Mauricio Reginato @LabReginato @DrexelBiochem @DrexelMedicine
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Reginato Lab retweeted
DrexelMCBG@DrexelMcbg
25 Apr 2024
Big congrats to Riley🧬🎉 @DrexelMcbg PhD Student Riley Young @LabReginato @DrexelBiochem @DrexelMedicine won the 1st Place for Best Trainee Short Talk Translational Cellular Oncology Retreat Sidney Kimmel Cancer Center Research Consortium @KimmelCancerCtr Well done Riley 🤩
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Reginato Lab retweeted
Noguchi Laboratory@NoguchiLab2004
20 Mar 2024
The lab got a good news 🤩 Well done Kalisse @afrogenomics @DrexelMcbg 🎉 From the wall display monitor @DrexelBiochem @DrexelMedicine 😉 #BiomedicalSciences #AgingResearch #Geroscience #GraduateSchool
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DrexelMCBG@DrexelMcbg
27 Feb 2024
MCBG Seminar 🧬🧬🧬 Thursday, March 7, 2024, 1 PM Dr. Christina M. Ferrer Assistant Professor Greenebaum Comprehensive Cancer Center University of Maryland @UMGCCC Identifying Tumor Cell Intrinsic and Microenvironmental Adaptations of Metastasis-Initiating Cells
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Reginato Lab retweeted
Drexel Biochemistry & Molecular Biology@DrexelBiochem
14 Feb 2024
Excited to host Dr. Cornelius Taabazuing @taabaman @BB_UPenn @PennMedicine for our department seminar series next Monday at 1 pm @DrexelMedicine
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Reginato Lab retweeted
Drexel Biochemistry & Molecular Biology@DrexelBiochem
6 Feb 2024
Looking forward to hosting Dr. Brian Capell @briancapell @PennEpiInst @PennCancer for our departmental seminar series next Monday @DrexelMedicine at 1 pm.
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Congrats to Riley Young @DrexelMcbg PhD student, for being chosen as 2024 Community Engaged Research Training for Emerging Scientists trainee at @KimmelCancerCtr Riley will develop a cancer related community outreach initiative to promote engagement between SKCC & community
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Congrats 🥳to PhD student Emily Esquea @esqueaemily @DrexelMcbg for receiving first prize 🥇for best trainee short talk at SKCC-Drexel Trainee Retreat #proudpi @KimmelCancerCtr @DrexelMedicine
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Reginato Lab retweeted
Trends in Endocrinology & Metabolism@Trends_Endo_Met
14 Dec 2023
Online Now: Fructose promotes liver cancer via microbial acetate-induced O-GlcNAcylation dlvr.it/T07Nqw #trends #endocrinology #metabolism
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Fun to write a Spotlight Review for @Trends_Endo_Met on recent study in @Cell_Metabolism on role of fructose-mediated liver cancer via regulation of acetate and O-GlcNAcylation with @DrexelMcbg students @esqueaemily & @_riley_young_ authors.elsevier.com/a/1iFV%…
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