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SanthanamLab@JHUSOM @LabSanthanam

Vascular stiffening - from molecules to mice!

Joined April 2021
  • Tweets 16
  • Following 19
  • Followers 37
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Congratulations Travis Brady @lowkeytrb! Such an honor to receive The APS Porter Fellowship!
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Congratulation to Travis Brady @lowkeytrb for his award winning poster at FEBS Transglutaminase conference! @2024TGDisease
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SanthanamLab@JHUSOM retweeted
Frontiers - Physiology@FrontPhysiol
7 Mar 2022
New Research: Editorial: Cardiovascular Remodeling in Aging and Disease frontiersin.org/articles/10.… #Physiology
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Latest from the Santhanam Lab - PDGF-BB links the bone-vascular axis and promotes #vascular #aging and #arterialstiffening. pubmed.ncbi.nlm.nih.gov/3443… @JHACCMResearch @HopkinsACCM

Skeleton-secreted PDGF-BB mediates arterial stiffening - PubMed

Evidence links osteoporosis and cardiovascular disease but the cellular and molecular mechanisms are unclear. Here we identify skeleton-secreted platelet-derived growth factor-BB (PDGF-BB) as a key...

pubmed.ncbi.nlm.nih.gov
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SanthanamLab@JHUSOM retweeted
JHU ACCM Research@JHACCMResearch
6 Aug 2021
Replying to @SamDasLab1
@SamDasLab1: Inactivating the TN/TX miRNA-degrading enzyme blocks #VSMC stiffness and #aging-associated aortic stiffness in vivo. New target for treating large artery stiffness and #Hypertension.
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Check out the latest paper from the Santhanam Lab: nature.com/articles/s41420-0… Tissue #transglutaminase, best known as "meat glue" and its role in celiac disease, is an important target in organ #fibrosis and vascular #aging.

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Recent studies have clearly illustrated that both vascular smooth muscle cells #VSMC and extracellular matrix #ECM are responsible for the mechanical decline of the arteries during #aging - but are they independent?
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Using #CRISPR -Cas9 gene editing, we created a new mouse model - the #Tgm2-C277S mouse, in which ECM remodeling and VSMC aging are uncoupled! In this model, we show VSMC aging emerges independent of ECM remodeling. @JSteppan @JHACCMResearch @HopkinsACCM
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SanthanamLab@JHUSOM retweeted
Communications Biology@CommsBio
9 Jul 2021
Addressing the limitation of inability to detect LOX catalytic function associated with diverse disease processes, Wang et al. developed an in situ activity assay by utilizing the reactivity of hydrazides with imines and carbonyls. @LabSanthanam nature.com/articles/s42003-0…
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Measure LOX activity in situ using our newly published method! rdcu.be/cnUwX @CommsBio , @JSteppan , @Huilei_Wang , @JHACCMResearch
Coming soon: A novel in situ activity assay for lysyl oxidases! Communications Biology - Nature.
Congratulations, Travis Brady, on your Ford Fellowship! bme.jhu.edu/news-events/news…

Travis Brady earns Ford Foundation Fellowship

In recognition of his work in the lab and his desire to lead the next generation of scientists, Travis Brady was recently awarded a Ford Foundation Fellowship. Brady is pursuing his PhD in biomedical...

bme.jhu.edu
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