@LabSwaminathan profile picture
Swaminathan Lab @LabSwaminathan

We are interested in all things cell biology but focused on studying cellular mechanotransduction.

Joined November 2018
  • Tweets 522
  • Following 398
  • Followers 1,411
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Swaminathan Lab@LabSwaminathan
4 Mar 2025
We have migrated to @swaminathanlab.bsky.social and hope you will join/follow us there for more science related discussions.
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Swaminathan Lab retweeted
bioRxiv Cell Biology@biorxiv_cellbio
8 Jan 2025
β1 Integrin-FAK-Piezo1 signalling axis drives in-situ stiffening mediated ECM remodelling and invasion of 3D breast epithelium biorxiv.org/cgi/content/shor… #biorxiv_cellbio

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🚨🚨REMINDER: Tenure-track and generously funded faculty position in "BASIC research into regenerative medicine and disease mechanisms" at our Wallenberg Center for Molecular Medicine (@LuWcmm ) at Lund University (@lunduniversity ).
Swaminathan Lab@LabSwaminathan
24 Sep 2024
🚨📷Be our colleague @lunduniversity!! @LuWcmm is recruiting 2 PIs (see ads below (and in thread)-link corrected) in Regenerative medicine. SO happy to see basic research being prioritised . These are Tenure Track positions with generous start-up packages. lu.varbi.com/en/what:job/job…
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🚨📷Be our colleague @lunduniversity!! @LuWcmm is recruiting 2 PIs (see ads below (and in thread)-link corrected) in Regenerative medicine. SO happy to see basic research being prioritised . These are Tenure Track positions with generous start-up packages. lu.varbi.com/en/what:job/job…

Associate Senior Lecturer (WCMM Fellow) in Molecular Medicine with a focus on basic research into...

In this call for proposals ( Wallenberg Molecular Medicine Fellow ), we are looking for prominent researchers with international research experience. The position is located at the Faculty of Medicine

lu.varbi.com
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2nd position in translational research in advanced therapy lu.varbi.com/en/what:job/job…

Associate Senior Lecturer (WCMM Fellow) in Molecular Medicine with a focus on translational...

In this call for proposals ( Wallenberg Molecular Medicine Fellow ), we are looking for prominent researchers with international research experience. The position is located at the Faculty of Medicine

lu.varbi.com
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Can't wait for Fibronectin, Integrin and Related Molecules (FIRM?) GRC! What a great lineup of speakers - fantastic from @WickstromLab @TanentzapfLab
Tanentzapf Lab@TanentzapfLab
24 Sep 2024
Replying to @WickstromLab
@WickstromLab & myself are happy to announce the program for the upcoming Fibronectin, Integrin & Related Molecules Gordon Research Conference. This is one of the oldest GRC conferences around (since 1982) & we put together an OUTSTANDING program for y'all. Registration is open.
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A beautiful tribute to the memory of Zijie Yan from @aps_unc , Rich Superfine and @UNC community. unc.edu/discover/carolina-re…

Carolina remembers Zijie Yan, ‘master of light and matter’ | UNC-Chapel Hill

Colleagues from the applied physical sciences department reflect on Yan’s legacy a year after his death.

unc.edu
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Fantastic thread on multi-cellular rotations by @onenimesa and @EpiMechFC
epithelial mechanics fan club@EpiMechFC
16 Jun 2024
Collective cell motion has many forms, but rotation is the coolest of them all. I'm @onenimesa, and in this short🧵, I'll highlight some instances of global tissue rotation like this one from @BauschLab
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" Integrins are molecular machines w/ parts that undergo large, ∼100 Å movements; however, we believed that we could not understand this machine and truly appreciate its soul—its animating principle—until we saw it move. "- Li et al. -What a tour de force cell.com/cell/fulltext/S0092…

Ligand binding initiates single-molecule integrin conformational activation

Viewing integrins in action through single molecules shows that ligand-dependent activation is the predominant factor initiating signaling.

cell.com
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so many key points in this study: 1. High affinity extended open binds it ligands slower than its low affinity closed state 2. Force transmitted or tension built across the molecule activates it- making it agnostic to identity of molecules
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3. Conformational changes occur at the timescale of milliseconds --crazzzy 4. Summary: outside-in events initiates rapid and coordinated conformation changes which are stabilised by inside-out events and generation of forces to stabilise integrin activation
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Exciting preprint from the awesome folks (Mavrakis & Brasselet group) at @InstitutFresnel on new fluorescent reporters that will allow for polarisation measurements (in addition to regular microscopy) of actin dynamics in live cells!This is a big deal! biorxiv.org/content/10.1101/…

Genetically encoded reporters of actin filament organization in living cells and tissues

The cytoskeletal protein actin is crucial for cell shape and integrity throughout eukaryotes. Actin filaments perform essential biological functions, including muscle contraction, cell division and...

biorxiv.org
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Coupling this incredible toolkit with the amazing microscope built by @TalonChandler Min Guo, Patrick La Rivière, and Hari Shroff et al. can push the limits of what we know about actin organisation in cells, tissues and model organisms.@mattersOfLight biorxiv.org/content/10.1101/…

Three-dimensional spatio-angular fluorescence microscopy with a polarized dual-view inverted...

Polarized fluorescence microscopy is a valuable tool for measuring molecular orientations, but techniques for recovering three-dimensional orientations and positions of fluorescent ensembles are...

biorxiv.org
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I'm on my way!
TurkuBioscience@BioscienceTurku
11 Apr 2024
Aleksi Isomursu @aisomursu from @IvaskaLab will defend his doctoral thesis "Biomechanics of cancer cell motility" on Friday 12th of April at 12:00 in the Tauno Nurmela auditorium @UniTurku . Aleksi's opponent will be Vinay Swaminathan from Lund University.
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...Alea iacta est.... Just kidding..All the tools involved in these conversations are really amazing..
Robert Haase@haesleinhuepf
8 Apr 2024
Bold statement "Transformers do not outperform Cellpose" by Stringer & Pachitariu 😯 No matter how this controversy ends, this preprint is a fantastic read to learn about good scientific practice in cell segmentation method comparison studies 🤩
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Great work! Also- Someone please set up a **taxis tournament- Single cell type , opposing gradients of same relative magnitudes (how and what?-not sure).. Hapto vs Chemo; Duro vs Curvo; Rheo vs Visco etc. -- Any guesses on winners?
Sylvain GABRIELE@GabrieleSylvain
15 Mar 2024
🚨 How do cells migrate when exposed to curvature cues? We addressed this question using a minimal model developed by Raj Kumar Sadhu & Nir Gov and various curved systems by @LucianoMarine1, @BLadoux and others @PNASNews 👇🏼 pnas.org/doi/10.1073/pnas.23…
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So happy to see this in preprint! Molecular orientation can be a critical property of protein organisation in cells that encodes a wide range of biophysical information that localisation alone can't. To get 3D orientation of molecules in cells in complex environment is exciting!
Talon Chandler@TalonChandler
13 Mar 2024
I’m thrilled to share our preprint: “Three-dimensional spatio-angular fluorescence microscopy with a polarized dual-view inverted selective-plane illumination microscope (pol-diSPIM)”, a new 3D take on fluorescence anisotropy. 🧵1/15 Preprint: ⬇️ biorxiv.org/content/10.1101/…
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So happy to see @wesley85979105's toil coming to fruition!
Jon Humphries@JDHL18
29 Feb 2024
Extracellular matrix dependent regulation of Septin 7 in focal adhesions promotes mechanosensing and response in fibroblasts. biorxiv.org/content/10.1101/… From @vin_swaminathan @wesley85979105 and colleagues
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Swaminathan Lab retweeted
mythreye_k@mythreyelab
8 Jan 2024
New year, New call for cancer biology papers at nature.com/collections/daadb… . DM us if any questions. @TorilHol @mythreyelab @CommsBio @NaturePortfolio #TME

Tumour microenvironment

This Collection welcomes submissions on the interplay between tumours and their microenvironment, as well as how these interactions impact on cancer therapy.

nature.com
Communications Biology@CommsBio
11 Dec 2023
Our latest #CallforPapers is on the tumour microenvironment (#TME), and is guest-edited by @TorilHol & @mythreyelab! We're excited about cell/mol mechanisms and signalling components underlying the TME, and how these interactions impact cancer therapy. nature.com/collections/daadb…
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Interested in #mechanobiology? How 'bout adhesions, nucleus & cytoskeleton across cells & tissues?MayB new molecular tools & biosensors or LLPS and PTMs are u'r thing? Catch it all @ Mechanobiology across length scales Minisymposia on Sunday 3:30PM @ASCBiology @EMBO #cellbio2023
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