We study membrane and microtubules fluctuations using flickering spectroscopy, simulations and theory. The main message: the MTs push on the membrane and deform it, but are deflected by this soft boundary and hence "transport" the deformations along the membrane creating "waves"

New preprint 🔥 my PhD swan song, with @BauschLab @hamfaizi @PVlahovska @HaganLab ( Matt, Sarvesh Layne & Aparna) biorxiv.org/content/10.1101/… We put a microtubules kinesin gel inside a GUV and... this happens: crazy fluctuations of a "cell" induced by a "minimal cytoskeleton"!

The next speaker of our #Future3DAM Cluster Conference 2024 is Andreas Bausch from @TU_Muenchen. He will present recent results on Structure Formation in Organoid Systems, explaining why Activity Matters. Register now! future3dam.org/registration-… #organoids #researchconference

(1/3) How do cells squeeze their large nucleus through tight spaces? In work led by @JeremyKeys92 and in collaboration with @mingmingwu2 (now at @biorxivpreprint) we found that cells can push their nucleus by pressurizing their rear (video - left): biorxiv.org/content/10.1101/…

If you ever need an overview of measurement methods of network #mechanics, here's a suggestion 😎 (Fig. 3 in our review) #Teaching Including work by @BauschLab @SchmollerLab on how actin networks with alpha actinin form bundles and stiffen after repeated shearing.

My first paper is out now. 🎉 We reconstitute the formation of VASP condensates on bilayers, which nucleate, polymerize and bundle actin filaments. The bundles grow by enhanced polymerization aligned to filaments. Thanks to @BleicherPhilip, @MarcoPayr and of course @Bauschlab.

Ondrej’s article appeared today in PNAS. I hope you enjoy reading this updated version.

Happy to see this fun collaboration out! Scroll down for more on the dual encoding of patterning and mechanics by morphogens, to preserve patterns throughout complex 3d morphogenesis!

Very nice..! And reminding of gliding systems with steric constraints!

New paper out in @NatureComms: polar patterns of filaments gliding *on a sphere*🌐nature.com/articles/s41467-0… A project from my PhD I love, with co-first Chiao-Peng and our old student Alice. Here a [long!] thread, with a bit of backstory, results, discussion and...cool movies!🧵1/22

Good stuff

Make a dough and let it rise; observe it to self-organise. Don't forget to mention, though; it is an MT-actin dough. Our minds are very bright; we made a smart composite. We are writing history; the composite has memory. biorxiv.org/content/10.1101/…

Less than one week to submit an abstract! 👇

🔥NEW PREPRINT🔥 How are collectively migrating cells constrained by the curvature & topology of 3D systems? We discovered a collective velocity wave propagating in such a system & show that it emerges as a response of active matter to curvature 👉 arxiv.org/abs/2110.14614

🎉Glad to see this one published: Microtubules tune mechanosensitive cell responses nature.com/articles/s41563-0… congrats to all authors and thanks @etiennemannevil and @shailajaseethar for the opportunity to image beautiful migrating astrocytes 🔬

And they do rotate ! Collective cell motion drive the self organization of mammary gland organoids structures nature.com/articles/s41567-0…