Personal views on the state of the world and occasional bits of science, especially axon degeneration and research culture. Much more science at š¦ @colemanlab
Joined July 2017
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Not all grant rejections are equal. Some are more devastating than others. As a researcher, how do you keep going in those moments?
The latest Science Without Anguish blog post discusses a topic we need to talk about much, much more!
sciencewithoutanguish.com/blā¦
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Michael Coleman retweeted
Jun 4
āI apologize, but this is a very busy period and therefore I canāt review this paper. However, I can recommend someone who can do a good job.ā
Jun 3
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Michael Coleman retweeted
How does the thalamus support consciousness?
Our new study uses restingāstate fMRI to show nucleusāspecific thalamocortical connectivity changes during anaesthesia and in disorders of consciousness.
#Neuroscience #Consciousness #fMRI #Thalamus
academic.oup.com/braincomms/ā¦
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Apr 12
Delighted to announce the latest preprint from our amazing team: biorxiv.org/content/10.64898ā¦
Laura Carlton and Emma Wilson report luciferase mapping of the human NMNAT2 and SARM1 promoters, naturally-occurring human gene variants within them and their functional consequences.
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Apr 12
Importance: These findings support disease association studies to link programmed axon death to specific human diseases. It is essential to move beyond the limitations of animal models and work in humans to understand where best to apply drugs blocking programmed axon death. 4/5
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Apr 12
Congratulations to Laura Carlton & Emma Wilson on these exciting findings, their first primary research articles as first & senior author respectively. Also thanks to Heba Morsy for in silico promoter analysis.
We look forward to working constructively with reviewers.
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Michael Coleman retweeted
Grateful & excited:
New paper alert by Simone Thomas with contributions from other @merkinpnnrcenter.bsky.social scholars ālive on PubMed now.
pubmed.ncbi.nlm.nih.gov/4150ā¦
#MerkinCenter #MerkinScholars #PeripheralNeuropathy #NerveRegeneration #TeamScience #Neurology #JohnsHopkins
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Michael Coleman retweeted
Jan 6
Delighted to say that our paper identifying a novel role for protrudin in endosomal fission has been published:
Protrudin acts at ER-endosome contacts to promote KIF5-mediated endoso... sciencedirect.com/science/arā¦
@TheCIMR @juliakleniuk
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15 Dec 2025
Today in Science Without Anguish:
'It's not what you know, it's who you....trust'.
When knowledge is really trust in disguise. And it's not absolute, itās greyscale.
Why knowing this helps us cope when our knowledge is challenged. sciencewithoutanguish.com/blā¦
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Michael Coleman retweeted
10 Dec 2025
If you grew up in the 1970s, you probably possess these rare traits.
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10 Dec 2025
This is dreadful. Do we have to cave
into Trumpism? This is not the US! Itās very simple: research in a culture of fear just doesnāt work. sciencewithoutanguish.com/blā¦. Funding research without also addressing culture is a waste of money.
10 Dec 2025
šØBREAKINGšØ
REF 2029: Research culture metric overhauled (and weighting reduced).
Research Excellence Framework reworked āto reduce burdenā, with elements of 2021 exercise reinstated.
All the headlines as the three-month pause ends. Free to read.
researchprofessionalnews.comā¦
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10 Dec 2025
Question to non US scientists: What effect will the proposed social media checks by US border control have on your willingness to attend conferences in the US?
0%
More likely to attend
50%
No significant change
25%
Less likely to attend
25%
Very unlikely to attend
4 votes ā¢ Final results
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1 Dec 2025
Today in Science Without Anguish: how we handle experiences that donāt fit our mental map. The many ways that cognitive dissonance plays out in academic research and the problems this causes us. sciencewithoutanguish.com/blā¦
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19 Nov 2025
Science WITH Anguish?
Grant rejection today. It never stops hurting no matter how successful or how many you dealt with before (this is no. 57). Thanks to my team for helping me handle it today. š Tomorrow we go on.
ECRs dealing with rejection: know that you are not alone!
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17 Nov 2025
Today in Science Without Anguish: Is blame bringing you down?
How we shackle ourselves by blaming others, also degrading workplace culture and raising our stress levels.
But can we avoid it without blaming ourselves instead?āØ
sciencewithoutanguish.com/blā¦
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3 Nov 2025
Today in Science Without Anguish: how failing to notice when the wind is behind us makes us believe the world is against us when things donāt go our way.
sciencewithoutanguish.com/blā¦
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Michael Coleman retweeted
21 Oct 2025
In our latest review with @DoctorPAF, we explore the breadth of therapeutic potential for the neurodegenerative enzyme SARM1.
We discuss:
-Challenges for SARM1 inhibition for neuroprotection
-Roles in non-neuronal cells
-SARM1 activation for selective peripheral neuroablation
Targeting SARM1: from inhibition for neuroprotection to activation for neuroablation dlvr.it/TNnCBh
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20 Oct 2025
In this weekās Science Without Anguish: āShort cuts to lost potentialā. How confusing the simplifications we make to understand the world with the real thing can lead us astray. sciencewithoutanguish.com/blā¦
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