Prof of Neurogenetics and Molecular Neurobiology, Cambridge Uni. NHS Clinical Geneticist. Study membrane traffic and axonal degeneration in HSP. Personal views.

Joined October 2010
10 Photos and videos
Delighted to say that our paper identifying a novel role for protrudin in endosomal fission has been published: Protrudin acts at ER-endosome contacts to promote KIF5-mediated endoso... sciencedirect.com/science/ar… @TheCIMR @juliakleniuk

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Evan Reid retweeted
4 Nov 2024
Our first cohort of students on our MPhil course 'Molecular Mechanism of Human Disease' are settling in so it's time to open applications for next year! Deadline is 3rd December and you can find all the details here 👇
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Evan Reid retweeted
Out at @naturemethods just now! nature.com/articles/s41592-0… We present #SN2N, a flagship level unsupervised denoising solution. It’s fully competitive with supervised learning without needing large training-set and clean ground-truth, using 1 noisy frame for training. (1/n)
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Congratulations! @SerenaNikZainal
Congratulations to Professor Nik-Zainal for winning the 2024 ESMO Award for Translational Research | Oncology Awards: esmo.org/about-esmo/awards/e…
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Evan Reid retweeted
Edward, Lena and I are hosting an ER session at #cellbio2024 #ASCBEMBO this year. It will be…awesome! 😂. Submit your abstracts and come join us!
22 Jul 2024
🚨With @AbellJonny & @Kosloverlab we are excited to organise  “The Endoplasmic Reticulum Structure and Function Across Cell Types” session at #cellbio2024 #ASCBEMBO! If you are interested in ER, its cellular functions, send us your abstracts by Aug 6🔬 ascb.org/cellbio2024/program…
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18 Jul 2024
Hopefully this provides more insights into how protrudin influences polarised membrane traffic and functions in neurite extension & axonal regeneration (the latter shown by another ex-colleague @ves_petrova and current colleagues @BartNieuwenhu1s, @RichardEvaLab, James Fawcett)
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18 Jul 2024
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Evan Reid retweeted
The latest preprint from our lab. Congratulations to the first author @EdenJess and thank you to all our wonderful collaborators. @TheCIMR @CellBiol_MRCLMB @JLS_Lab
RABGAP1 acts as a sensor to facilitate sorting and processing of amyloid precursor protein biorxiv.org/cgi/content/shor… #biorxiv_cellbio
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It is well worth reading the paper that Cahir links to here. And stop using n= number of cells please.
"Failure to recognize that cells are not independent replicates when testing for differences in means with t tests or ANOVA causes pseudoreplication, an extremely common and serious error that artificially decreases P values and can create false positive effects."
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Our latest thing: Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in... sciencedirect.com/science/ar…

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Worth a look if you're interested in how #ERshape can affect other cellular processes. Also gives some insights into the pathogenesis of #hereditaryspasticparaplegia #HSP in human neurons
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17 Apr 2024
Looking forward to seeing this blog site from @Lab_Coleman develop. Essential reading for all scientists, but especially useful for those pre-tenure: Science Without Anguish - My Site sciencewithoutanguish.com/1/…

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