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Alexis Vallée-Bélisle @LaboAVB

Prof. Chimie @UMontreal; Titulaire @CRC_CRC en Bio-ingénierie et Bio-nanotechnologie; Co-founder Anasens #startup #Nanotechnology #Biosensors #Chemistry

Joined October 2022
  • Tweets 83
  • Following 112
  • Followers 128
23 Photos and videos
Alexis Vallée-Bélisle retweeted
J. Am. Chem. Soc.@J_A_C_S
21 Dec 2024
Programming the Kinetics of Chemical Communication: Induced Fit vs Conformational Selection | Journal of the American Chemical Society @UMontreal @LaboAVB #Programming #Kinetics #Chemical #Communication #InducedFit #Conformation pubs.acs.org/doi/10.1021/jac…

Programming the Kinetics of Chemical Communication: Induced Fit vs Conformational Selection

Life on Earth depends on chemical communication and the ability of biomolecular switches to integrate various chemical signals that trigger their activation or deactivation over time scales ranging...

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1) Latest work from the lab (in @J_A_C_S): : how nature programs the kinetic of its molecular systems and to use this information to build better nanotechnology. Link to article: pubs.acs.org/doi/10.1021/jac…

Programming the Kinetics of Chemical Communication: Induced Fit vs Conformational Selection

Life on Earth depends on chemical communication and the ability of biomolecular switches to integrate various chemical signals that trigger their activation or deactivation over time scales ranging...

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2) Here is simplified version of the article: nouvelles.umontreal.ca/en/ar…

Tinkering with the “clockwork” mechanisms of life

Opening new doors for the development of nanotechnologies in medicine, UdeM scientists recreate two natural mechanisms to better program the timescale of molecular communication and functionality.

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3) Thanks to Carl-Prévost Tremblay, Achille Vigneault, and @DomLauz for their hard work on the project. Thanks also to the funding agencies: @NSERC_CRSNG, @FRQ_NT and @ProteoQuebec #DNA #RNA #ChemicalBiology #protein #sensor #Nanotechnology #SyntheticBiology #Nanomachines
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1) Les derniers travaux du labo (dans @J_A_C_S): comment la nature programme la cinétique de ses systèmes moléculaires et comment utiliser ces stratégies pour développer de meilleures nanotechnologies. Lien vers l’article: pubs.acs.org/doi/10.1021/jac…

Programming the Kinetics of Chemical Communication: Induced Fit vs Conformational Selection

Life on Earth depends on chemical communication and the ability of biomolecular switches to integrate various chemical signals that trigger their activation or deactivation over time scales ranging...

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2) Voici une version vulgarisée de l’article: nouvelles.umontreal.ca/artic…

Bricoler les mécanismes d'horlogerie de la vie

Des scientifiques de l'UdeM ont recréé deux mécanismes biochimiques naturels pour programmer des nanomachines, offrant de nouvelles perspectives en médecine grâce à des minuteurs moléculaires.

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3) Merci à Carl-Prévost Tremblay, Achille Vigneault et @DomLauz pour leurs contributions à ce projet. Un grand merci aux organismes subventionnaires: @NSERC_CRSNG, @FRQ_NT et @ProteoQuebec
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Life is sustained by thousands of different self-assembled nanomachines. How were these systems created, programmed, and fine-tuned to support life? See our latest paper in @angew_chem, which may also inspired the design of new nanotechnologies: onlinelibrary.wiley.com/doi/… (1/3)

Design and Thermodynamics Principles to Program the Cooperativity of Molecular Assemblies

Molecular assembly can be designed by fusing binding domains. A precise optimization of the level of compaction of the assembly using linker of different lengths or compositions can provide a simple...

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Briefly, using simple DNA-based models, we illustrate how molecular assemblies may have evolved to create complex self-regulating functions ranging from improved cooperativity to self-inhibition while demonstrating the thermodynamic framework to create such nanosystems. (2/3)
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Congrats @DomLauz and thanks to the funding agencies: @NSERC_CRSNG, @FRQ_NT, @ProteoQuebec, @NSERC_PROMOTE, @TIPS_SPIIE #CRC (3/3)
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La vie est soutenue par des milliers de nanomachines auto-assemblées, mais comment ces systèmes ont-ils été créés, programmés et réglés pour soutenir la vie ? Voir notre dernier article dans @angew_chem : onlinelibrary.wiley.com/doi/… (1/3)

Design and Thermodynamics Principles to Program the Cooperativity of Molecular Assemblies

Molecular assembly can be designed by fusing binding domains. A precise optimization of the level of compaction of the assembly using linker of different lengths or compositions can provide a simple...

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Petit résumé. Avec des modèles simples d'ADN, on montre comment ces assemblages moléculaires ont pu évoluer pour créer des fonctions autorégulatrices complexes allant de la coopérativité à l'auto-inhibition, le tout, en expliquant le cadre thermodynamique pour les créer. (2/3)
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Félicitation à @DomLauz et merci aux organismes subventionnaires: @NSERC_CRSNG, @FRQ_NT, @ProteoQuebec, @NSERC_PROMOTE et @TIPS_SPIIE #CRC. (3/3)
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Alexis Vallée-Bélisle retweeted
Angewandte Chemie@angew_chem
7 Feb 2024
Design and Thermodynamics Principles to Program the Cooperativity of Molecular Assemblies (Alexis Vallee-Belisle and co-workers) @LaboAVB #openaccess onlinelibrary.wiley.com/doi/…

Design and Thermodynamics Principles to Program the Cooperativity of Molecular Assemblies

Molecular assembly can be designed by fusing binding domains. A precise optimization of the level of compaction of the assembly using linker of different lengths or compositions can provide a simple...

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(4/5) Pour lire l’article original publié dans / To read the main article published in @J_A_C_S: pubs.acs.org/doi/full/10.102…

Programing Chemical Communication: Allostery vs Multivalent Mechanism

The emergence of life has relied on chemical communication and the ability to integrate multiple chemical inputs into a specific output. Two mechanisms are typically employed by nature to do so:...

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(5/5) Un gros merci à @AlexGelle d’avoir si bien vulgarisé nos travaux. Merci (thanks) aux organismes subventionnaires: @NSERC_CRSNG, @FRQ_NT, @ProteoQuebec & @NSERC_PROMOTE.
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(1/5) Les travaux de doctorat de @DomLauz réalisé à @UMontreal se retrouvent parmi les 10 découvertes de l'année 2023 de @QuebecScience! Plongez dans les secrets de la communication chimique et des langages moléculaires: nouvelles.umontreal.ca/artic…

Découvertes de l’année de «Québec Science»: trois équipes de recherche de l’UdeM en lice

En 2023, parmi les 10 découvertes québécoises mises à l’honneur par le magazine «Québec Science», 3 sont le fait d’équipes de l’Université de Montréal dans les domaines de la chimie et de la médecine.

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(3/5) Votez pour la découverte de l'année ici (#4) / Vote for the discovery of the year here (#4): quebecscience.qc.ca/decouver…

Votez pour votre découverte préférée!

Notre jury a sélectionné les 10 découvertes québécoises les plus impressionnantes de la dernière année. À votre tour de choisir la découverte qui vous surprend ou vous inspire le plus.

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(2/5) Our @J_A_C_S paper was selected among the top 10 discoveries of 2023 in @QuebecScience! Dive into the secrets of chemical communication and molecular languages: nouvelles.umontreal.ca/en/ar…

Decoding how molecules "talk" to each other to develop new nanotechnologies

Université de Montréal scientists recreate and compare molecular languages at the origin of life – opening new doors for the development of novel nanotechnologies.

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Which molecular language should you use to program your favorite chemical, biochemical or nanotechnological systems? See our latest comparative study of two molecular languages at the origin of life published in @J_A_C_S. nouvelles.umontreal.ca/en/ar… #nanotechnology #DNA (1/3)

Decoding how molecules "talk" to each other to develop new nanotechnologies

Université de Montréal scientists recreate and compare molecular languages at the origin of life – opening new doors for the development of novel nanotechnologies.

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Quick summary: We have programmed a DNA-based nanosystem using two different chemical languages: allostery and multivalency (system inspired from Plaxco & @RicciLab). See how the different languages affect the programmability of molecular systems. pubs.acs.org/doi/10.1021/jac… (2/3)

Programing Chemical Communication: Allostery vs Multivalent Mechanism

The emergence of life has relied on chemical communication and the ability to integrate multiple chemical inputs into a specific output. Two mechanisms are typically employed by nature to do so:...

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Congrats again to @DomLauz and thanks to the funding agencies: @NSERC_CRSNG, @FRQ_NT, @ProteoQuebec, @NSERC_PROMOTE, @TIPS_SPIIE and to editor @SleimanHanadi at @J_A_C_S (3/3)
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