Assistant Professor @UPenn | Study epigenetics, gene regulation and cancer | views my own
Joined September 2017
- Tweets 686
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45 Photos and videos
Pinned Tweet
4 Aug 2025
(1/n) Excited to share our new preprint! We uncover that RNA actively promotes nucleation and function of pathogenic condensates, amplifying locus-specific oncogenic transcription and promoting tumorigenesis. #epigenetics #condensates #cancer #RNA biorxiv.org/content/10.1101/…
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Liling Wan retweeted
Jun 12
Online Now: RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription dlvr.it/TT0yzt
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Jun 12
Excited to share that our preprint 'RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription' is now online @MolecularCell cell.com/molecular-cell/full… @PennMedCSO @PennCancer @PennEpiInst
4 Aug 2025
(1/n) Excited to share our new preprint! We uncover that RNA actively promotes nucleation and function of pathogenic condensates, amplifying locus-specific oncogenic transcription and promoting tumorigenesis. #epigenetics #condensates #cancer #RNA biorxiv.org/content/10.1101/…
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Apr 30
Join us Aug 3–6 in Porto for the #FASEB Biological Acetylation Conference! great lineup spanning #chromatin #epigenetics #metabolism #cancer and drug development! keynotes by Asifa Akhtar and Shelley Berger! #BAHSRC2026 events.faseb.org/event/biolo…
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Liling Wan retweeted
Apr 25
Jane Ying Wu, who took her own life, was cleared of wrongdoing by the US National Institutes of Health. Her family alleges that her employer destroyed her career. go.nature.com/3OZDs51
ALT Neuroscientist Jane Ying Wu was the subject of an investigation by the US National Institutes of Health as part of US President Donald Trump\u2019s China Initiative. Credit: Courtesy of Elizabeth Rao
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Apr 18
Heading to San Diego for #AACR26! excited to present our latest work on condensates at the Major Symposium on chromatin, epigenetics, and cancer, alongside leaders in the field @TheRobertsLab1 @Armstrong_dfci. Come join the discussion if you’re interested! @PennMedicine
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Liling Wan retweeted
Jan 30
Just ~1 month until our @KeystoneSymp on Epigenetics and Gene Regulation in Health and Disease! keystonesymposia.org/confere…
@kjarmache and I have tailored this meeting around the unique basic and translational science in our field, addressing both challenges and new opportunities in moving mechanisms to successful drug development. Join us and reach out if you have questions!!
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Jan 25
A short but wonderful visit at UCSF - thanks to Xiaokun @ShuLab2010 and Danica for the invitation to share our work on #epigenetics #condensates #cancer and to friends (old and new) for the great discussion! And so glad I made it home before the snowstorm shut everything down
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Jan 7
Congrats @Amgen @jaybradner and Dark Blue Therapeutics! Exciting to see ENL/MLLT1 biology advancing toward therapeutic translation in AML - a great example of how basic chromatin biology can inform new treatment strategies.
Jan 6
Thanks Bruce @LifeSciVC. Time cannot move fast enough to bring this brave idea and prototype medicine to patients with AML. As a stem cell transplant physician, I am well calibrated to the challenge AML patients face. All learnings, insights and leaders at @Amgen in ALL will be accessible to this amazing team of innovators.
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6 Nov 2025
Check out the 2nd version of our preprint “RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription” and feedback welcome!
biorxiv.org/content/10.1101/…
4 Aug 2025
(1/n) Excited to share our new preprint! We uncover that RNA actively promotes nucleation and function of pathogenic condensates, amplifying locus-specific oncogenic transcription and promoting tumorigenesis. #epigenetics #condensates #cancer #RNA biorxiv.org/content/10.1101/…
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26 Sep 2025
Excited to present our work and chair this #aacrpediatric25 session focusing on mechanisms in pediatric cancer. Great lineup including @TheRobertsLab1 @FilbinMariella highlighting emerging concepts in #epigenetics and #transcription dysregulation and how to target them!
Mechanisms Underlying Childhood Cancer:
Charles Roberts, Mariella G. Filbin, Liling Wan, Susu Zhang, and Alexander Zhang addressed this topic in a plenary session at the AACR Conference on Pediatric Cancer Research.
#AACRpediatric25 @TheRobertsLab1 @FilbinMariella @LilingWanLab
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4 Aug 2025
(1/n) Excited to share our new preprint! We uncover that RNA actively promotes nucleation and function of pathogenic condensates, amplifying locus-specific oncogenic transcription and promoting tumorigenesis. #epigenetics #condensates #cancer #RNA biorxiv.org/content/10.1101/…
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4 Aug 2025
(7/n) We propose that pathogenic condensates exploit RNA to reinforce locus-specific nucleation and amplify transcriptional programs that drive disease. This may set them apart from normal condensates which may be more sensitive to RNA-mediated negative feedback.
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4 Aug 2025
Kudos to co-first authors Krista Budinich, Xinyi Yao & Chujie Gong and all other co-authors! Thanks to our collaborators, and funding @NIH @AmericanCancer @pewtrusts @LLSusa @TheVFoundation @psscra @ASH_hematology
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Liling Wan retweeted
1 Aug 2025
The power of a bipartisan America—that refuses to dismantle science, cares about patients, and understands that medical academic research is also an economic engine. Thank you to the senators who stood up for NIH and the future of American health. science.org/content/article/….
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