@Lingchen_H profile picture
何灵尘 Lingchen He @Lingchen_H

Someone‖Postdoc‖MGEs‖HGT‖Phage person but sometimes anti-phage

Joined October 2020
  • Tweets 482
  • Following 291
  • Followers 124
30 Photos and videos
Pinned Tweet
何灵尘 Lingchen He@Lingchen_H
9 Sep 2025
Thrilled to share our discovery of a new horizontal gene transfer mechanism: tail-less cf-PICIs hijack free phage tails extracellularly, forming infectious chimeric virions that drive both intra- and inter-species transfer among bacteria. @jonaszpatkowski @jrpenades @CostaT_Lab
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No crazy idea today, bored.
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I had a very good idea, however, it just been done by others...And many follow-up will come...
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何灵尘 Lingchen He retweeted
Tominaga K. (tomiken)@pacyc1841
May 28
Temperate phages enhance bacterial host fitness via RNA-guided flagellar remodelling | Nature Microbiology nature.com/articles/s41564-0…

Temperate phages enhance bacterial host fitness via RNA-guided flagellar remodelling

Nature Microbiology - The prophage of a clinical Enterobacter isolate uses an RNA-guided transcription factor to alter flagellar composition, leading to enhanced bacterial motility and improved gut...

nature.com
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何灵尘 Lingchen He retweeted
Nature Microbiology@NatureMicrobiol
Apr 30
Streptomyces produce a diphtheria toxin-like exotoxin that targets insects dlvr.it/TSJB0r #MicroSky

Streptomyces produce a diphtheria toxin-like exotoxin that targets insects

Nature Microbiology - Bioinformatic, structural and functional analyses characterize Streptomyces antiquus insecticidal protein (SAIP) as a diphtheria toxin homologue that is lethal to insect cells...

nature.com
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何灵尘 Lingchen He retweeted
David J. Castillo-Cornejo PhD. 🔬@davesnetvault
Apr 21
I bring to you: Light driven SDS-PAGE polymerization. No TEMED, No APS, no stinky neurotoxic curing reagents: Just clean light and fast photo polymerization (Curing time: 15 min). No federal funding no stupid COÑASHIT, no academic clowns. Independent science!
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Look at this great opportunity!
Paul Hoskisson 😷🔬🧫🧬🐸🐍🦎@PaulHoskisson
Apr 23
Come and study for a PhD with us on antibiotic-producing #Streptomyces, trying to understand the roles of primary metabolic enzymes with additional cellular roles - Details below - please RT findaphd.com/phds/project/pr…
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I don't know why, the night is always young.
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何灵尘 Lingchen He retweeted
Vivek Mutalik@vivek_mutalik
Apr 3
🥳 Huge preprint 🔔 Today we share something our group has been working toward for a long time, led by @LucasMoriniere We asked can we predict which receptor a phage targets from its genome sequence alone? For most phages, we couldn’t. So Lucas set out to do something crazy!
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何灵尘 Lingchen He retweeted
Ciencia CEU UCH@CienciaUCHCEU
Mar 31
Hoy en @eldebate el hallazgo sobre cómo los virus ‘escuchan’ a otros virus, de los investigadores de @uchceu José R Penadés @jrpenades y Nuria Quiles @quiles_nuria, con el @IBV_CSIC y el Imperial College London @imperialcollege, publicado en @CellPressNews eldebate.com/espana/comunida…

Los virus ‘escuchan’ a otros virus: investigadores de la Universidad CEU UCH participan en un nuevo...

José R. Penadés y Nuria Quiles forman parte del estudio internacional que acaba de publicar la revista Cell, con el Instituto de Biomedicina de Val...

eldebate.com
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何灵尘 Lingchen He retweeted
Peter Fineran@PeterFineran
Mar 4
New post-doctoral research position available in my Phage-host interactions (Phi) laboratory at the @otago in the Department of Microbiology and Immunology. The project is focused on defences against jumbo phages. Please share and if interested apply using the link below.
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really enjoy
nature
@Nature
Mar 17
Nature research paper: Capturing dynamic phage–pathogen coevolution by clinical surveillance go.nature.com/4saG9iC
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If I don't read papers, nobody can blame me for scoping ideas and not appropriate citations...
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👏🏻
ugobananas@ugobananas_uuu
Mar 3
This is the first time we observed bacteria use plasmolysis to defence against phages! biorxiv.org/content/10.64898… Thanks all the authors to discover this together! @NobregaFL @ZhiyingZ_960228 @garushyants Dinshaw and Eugene
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Don't worry, I will have a good idea tomorrow.
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I will try to understand such a beautiful work.
Tominaga K. (tomiken)@pacyc1841
Jan 24
Bacteriophages mobilize bacterial defense systems via lateral transduction | Science Advances science.org/doi/full/10.1126…
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Congrats!!!
Ramesh Wigneshweraraj@wig_r
22 Oct 2025
A new article by @JoshMcquail @ImperialInfect @CBRB_Imperial and colleagues from @Uni_WUE on Hfq condensates and their function in metabolism and non-coding RNA maintenance academic.oup.com/nar/article…
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Very beautiful work, Congratulations!
Yifan ZHOU@yifanZHOU96
17 Oct 2025
Our work on viruses and virus satellites of haloarchaea and their DPANN symbionts is out today in Nature Microbiology! @NatureMicrobiol nature.com/articles/s41564-0…
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何灵尘 Lingchen He retweeted
Tominaga K. (tomiken)@pacyc1841
17 Oct 2025
Viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts reveal intricate nested interactions | Nature Microbiology nature.com/articles/s41564-0…

Viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts reveal intricate...

Nature Microbiology - An exploration of the viromes of haloarchaea and their ultra-small DPANN symbionts reveals plasmid-derived satellites of viruses from both archaeal groups, highlighting the...

nature.com
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何灵尘 Lingchen He retweeted
Cryptic Prophage (phage 🧬🪤 in 🦠)@crypticprophage
16 Oct 2025
academic.oup.com/nar/article… We discovered a new, wide-spread phage defense system based on serine recombinase PinQ in E. coli cryptic prophage Qin that inverts 1,797 bp in another cryptic prophage, e14, to encode two chimeric proteins that block adsorption of T2 phage. @NAR_Open

Adsorption of phage T2 is inhibited due to inversion of cryptic prophage DNA by the serine recomb...

Abstract. Recombinases catalyze site-specific integration, excision, and inversion of DNA and are often found adjacent to anti-phage system genes clustered

academic.oup.com
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