Professor at Washington University in STL uses biophysics to study mechanisms of protein-DNA interactions, helicases and SSB proteins. views are my own.
Joined December 2021
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16 Feb 2022
Just published in PNAS. A great collaboration between the @GalburtLab and @Lohman_Lab led by graduate student Ankita Chadda
PNAS February 22, 2022 119 (8) e2114501119; doi.org/10.1073/pnas.2114501…
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Tim Lohman retweeted
25 Oct 2024
Jeff Bezos has forced The Washington Post - the newspaper he owns - to not endorse in a presidential race for the first time 36 years because he’s worried Donald Trump will take away his government contracts.
RETWEET if you think @JeffBezos is a disgrace to democracy!
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Tim Lohman retweeted
24 Sep 2024
Janice L. Robertson to Receive 2025 Agnes Pockels Award in Lipids and Membrane Biophysics
ow.ly/kYpV50TuGhz
@WUSTL @RobertsonWUSTL
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Tim Lohman retweeted
11 Sep 2024
We are hiring! Position open for a new assistant professor in the Department of Biophysics & Biophysical Chemistry in @HopkinsMedicine . Considering all areas in experimental and computational biophysics. Please spread the word. apply.interfolio.com/154014
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8 Sep 2024
Conformational change in transitioning from the inactive UvrD1 monomer-DNA structure to the leading subunit of the activated UvrD1 dimer-DNA structure. biorxiv.org/cgi/content/shor…
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7 Sep 2024
Happy to share our collaborative work with Eric Galburt's lab led by Dr. Ankita Chadda and Dr. Binh Nguyen describing the first structures of dimeric superfamily 1A UvrD-family helicases from M. tuberculosis bound to a DNA junction.
biorxiv.org/cgi/content/shor…
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These structures show a massive conformational change compared to monomeric UvrD-DNA junction structures. Dimerization occurs via the 2B domains of each subunit which activates the helicase by preventing the inhibitory 2B domain-DNA interactions in the monomer-DNA structure.
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7 Sep 2024
The same 2B domain interface occurs in E. coli UvrD dimers suggesting that this is a general interface for SF1A helicases, including Rep and PcrA.
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Tim Lohman retweeted
Join us this afternoon for Melanie's thesis defense!
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26 Feb 2024
Hetero-dimerization of a wild type and mutant superfamily 1 DNA translocase, neither of which possess DNA helicase activity, results in an active DNA helicase by relieving the auto-inhibition within the monomeric enzyme.
doi.org/10.1101/2024.02.20.5…
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26 Feb 2024
Hetero-dimerization of a wild type and mutant superfamily 1 DNA translocase, neither of which possess DNA helicase activity, results in an active DNA helicase by relieving the auto-inhibition within the monomeric enzyme.
Hopefully this link will work.
biorxiv.org/content/10.1101/…
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Tim Lohman retweeted
26 Feb 2024
#NASmember E. Peter Geiduschek was a pioneer of DNA structure and gene expression, and to those who knew him, a "model of rigor and scientific precision as well as of generosity, kindness, and collegiality." Read more in a new memoir: ow.ly/qeRX50QHPAH #MemoirMonday
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Tim Lohman retweeted
12 Dec 2023
Join our team! We are seeking passionate postdocs for groundbreaking research on cytoskeletal motor proteins at @EinsteinMed @ScienceCareers @PostdocJobs 🧬
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17 Nov 2023
In good conscience, I cannot remain on this platform due to the despicable nature of the owner. You can find me on Blue Sky (@Lohman.bsky.social)
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20 Oct 2023
New pre-print (biorxiv.org/content/10.1101/…) spearheaded by Nicole Fazio @nicfaz9 and Kacey Mersch @KaceyMersch showing that the
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20 Oct 2023
This also indicates that ssDNA translocation does NOT limit the rate of DNA unwinding and that the nuclease domain may affect the rate of base pair melting.
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