A computational and chemical biology lab at the Weizmann Institute of Science.
Joined December 2015
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- Followers 3,595
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132 Photos and videos
Pinned Tweet
11 Mar 2025
Manuscript alert! I’m excited to finally share our manuscript on PINCHs, now on bioRxiv:
biorxiv.org/content/10.1101/…
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11 Mar 2025
Manuscript alert! I’m excited to finally share our manuscript on PINCHs, now on bioRxiv:
biorxiv.org/content/10.1101/…
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11 Mar 2025
These findings introduce a new paradigm in targeted protein degradation, with broad implications for chemical biology and therapeutic development. I’d welcome feedback from the community on this emerging modality.
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11 Mar 2025
The work was spearheaded by Ella Livnah who almost single-handedly performed all of the experiments - herculean style, with invaluable feedback from co-corresponding author Emmanuel Levy who is a world-leader on protein symmetry and agglomeration.
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25 Dec 2024
Combining covalent chemistry with proximity inducers expands their scope, and drives new discoveries. I tried to capture the state of the field in this (open access) comprehensive review. Good news - there are plenty of opportunities up for grabs :) pubs.acs.org/doi/10.1021/acs…
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London Lab retweeted
We are looking forward to the 4th Virtual ChemBio Talks with a full program with keynotes @KateCarrollLab and Kai Johnsson, talks by @Malins_Lab, @london_lab, @DerbyLabDuke, Sebastian Essig and @ChellanResearch as well as our Flash Talks.
Register now: web.cvent.com/event/7b3b6cdf…
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5 Mar 2024
Check out the Kupcinet-Getz International Summer Program @WeizmannScience bit.ly/3VxJCXI a great opportunity to visit and get a taste of science.
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29 Feb 2024
For the #covalent enthusiasts, check out the BPS "Emergence of irreversible modulation in drug discovery" meeting. Looks like a high local concentration of electrophiles :) my.bps.ac.uk/events/details/…
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29 Feb 2024
Such an elegant idea from the Gray lab! Target two nucleophiles simultaneously to reduce the probability of resistance mutation formation. Dielectrophiles were previously reported, but to my knowledge not in the context of avoiding resistance. Very cool.
pubs.acs.org/doi/10.1021/acs…
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London Lab retweeted
29 Jan 2024
Covalent Hits and Where to Find Them - from @AstraZeneca sciencedirect.com/science/ar…
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London Lab retweeted
29 Jan 2024
Our recent @ScienceMagazine article has been downloaded 24,806 times! So encouraging to see so much interest in our crowdsourced, open-science effort to find an accessible and affordable #COVID19 antiviral.
Here's the link in case you missed it ➡️scim.ag/4LB
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30 Jan 2024
For those interested in #drugresistance check out this GRC co-chaired by @mitchell_sysbio grc.org/drug-resistance-conf…
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London Lab retweeted
17 Jan 2024
5 Jan 2024
More structures were solved using data collected at @DiamondLightSource in 2023 than any other synchrotron, with ~1500 entries. This was closely followed by APS (@advancedphoton) with ~1400 entries, then SSRF (Shanghai), SLS (@psich_en) and ESRF (@esrfsynchrotron). 5/10
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London Lab retweeted
11 Jan 2024
📢 Friedrich-Stolz Award Of The GDCh
For outstanding commitment, scientific discovery or innovative technology that contributes to substantial therapeutic innovation.
🏆 5,000€ and a lecture at FiMC 2024.
🗓️ Submission deadline is January 31
🔗 buff.ly/47qyLV6
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London Lab retweeted
27 Dec 2023
The incredible @asap_discovery team members working with @XChem_DLS collected 14,631 X-ray datasets and deposited 6.7% of all X-ray structures in the PDB for ASAP in 2023 to advance structure-based antiviral discovery--with hundreds more pending release. 🚀
ALT Slide summarizing statistics from the ASAP Structural Biology Core: Collected 14,631 datasets as of 4th December 2023. Rolling average consistently >1,000 samples/month for Q4 2023 Originally predicted ~500 samples/month 601 structures deposited in PDB by ASAP in 2023 (6.7% all X-ray structures) 924 for all of Diamond, 776 for all American synchrotrons >200 pending release
ALT The incredible structural biology team from ASAP standing in front of the NYC skyline wearing hoodies featuring the ASAP logo.
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