Systems Biologist untangling Host-Drug-Microbiome interactions | PI at @UMassMed School | Trying to keep the BS to a minimum | @amitchel on the blue place

Joined July 2016
195 Photos and videos
Pinned Tweet
Why are some non-antibiotic drugs toxic to bacteria 💊☠️🦠? Do they work like standard #antibiotics (ABX)? Our latest work by @MarianaNoto published @ScienceMagazine addresses this fundamental question (1/n) science.org/doi/10.1126/scie…
11
102
316
80,546
Never-have-I-ever seen technology racing forward as fast as #LMMs in the past two years. Watching the @OpenAI releases coming out in real-time in their twelves-days series is jaw dropping! 🤖🌊 youtube.com/playlist?list=PL…
2
282
The ability of LMMs (chatGPT here) to *assist* in generating useful code for biologists a mind-blowing power multiplier 🤯! My advice to biologists at all career stages: Learn to code, its a superpower 🦸‍♀️🦹‍♂️ (for example, counting fluorescent colonies from mouse microbiome) 🧪🦠
2
10
794
Our second paper on the bacterial toxin colibactin is now out on mBio, this time we critically evaluated the claim that colibactin toxicity necessitates cell-cell contact 🧪🦠🧵(1/9) journals.asm.org/doi/10.1128…
1
4
54
4,570
I love this work since it a wonderful demonstration of (1) Serendipity in research – it started unexpectedly when we saw an active reporter even in non-contacting colonies and (2) it shows the power of simple experiments and quantitative microscopy (8/9)
1
145
Credit for this work goes to my former student Dr Emily Lowry. @emily_lowry23 literally submitted the revised version of this manuscript at the very last minute before leaving the lab 🥳 (9/9)
2
137
Can’t believe we unlocked this level of the #AI hype - huge adds for @AnthropicAI in airports (Boston & Atlanta). Wonder what % of ppl even know what’s the product (<0.1% probably)
1
3
561
We found that the bacterial #toxin colibactin acts as a double-edged sword and inflicts self-damage (evident in hundreds of genomes). Our recent collaboration with @DaganLab is now out on @genomeresearch genome.cshlp.org/content/34/…
1
7
18
2,966
This study was truly an exciting one, with many plot twists along the way. All credit goes to @emily_lowry23 who led the study and collaborated with @iwangtoknow on the analysis of the mutation pattern.
1
1
2
303
We are extremely curious to know if there are other known cases of self-inflicted damage from toxins in bacteria (would greatly appreciate replies to this thread)
1
1
302