Joined March 2019
8 Photos and videos
Lukas Hafner retweeted
Most experiments fail, and negative results rarely get published. This means LLMs are unaware of the outcomes of most experiments.
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With AI getting better and better: will "taste" become the "key" human skill; e.g. the sense of knowing what is "good" and/or "true"?
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Lukas Hafner retweeted
1/ Do you have a favorite protein you wish you could dissect residue by residue? 🔬 Excited to share our platform for mutational scanning at endogenous loci in yeast (no ectopic expression needed!) doi.org/10.1101/2025.09.09.6…

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Lukas Hafner retweeted
🌎👩‍🔬 For 15 years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵 Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open. doi.org/10.1101/2024.07.30.6…
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Lukas Hafner retweeted
How do we build AI systems that enable deeper, not just faster, science? I came across a very thought-provoking article by @nisheethvinoi on “What Counts as Discovery?”
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Lukas Hafner retweeted
21 Feb 2025
Legitmately thrilled to share our latest work, in which @fernpizza solved an experimental challenge in plasmid biology as old as the field: measuring how plasmids compete and evolve within individual cells!
Replying to @baym
Here we show that within-cell competition is key to plasmid evolution. Link to the paper! (2/n) biorxiv.org/content/early/20…
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Lukas Hafner retweeted
📢 First paper from my Postdoc is out. The field of stem cell-based embryo models is flourishing. These models mimic critical stages of embryo development, providing powerful tools to study processes that are tricky to dissect in natural embryos. Many approaches are being used to investigate them—what was ours? 👇 nature.com/articles/s41467-0…
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Lukas Hafner retweeted
We’re releasing Humanity’s Last Exam, a dataset with 3,000 questions developed with hundreds of subject matter experts to capture the human frontier of knowledge and reasoning. State-of-the-art AIs get <10% accuracy and are highly overconfident. @ai_risk @scaleai
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Lukas Hafner retweeted
Listen to this one to hear a debate about some of the best medical AI papers of the past few years, lots of laughter, and a rare long-form glimpse into @zakkohane’s special mentoring style.
15 Jan 2025
Dr. @zakkohane discusses the evolving landscape of AI in medicine and shares insights on health care system challenges, the Human Values Project, and his perspectives on the most significant AI developments of 2024. Listen to the full episode: nejm.ai/ep26
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Lukas Hafner retweeted
14 Jan 2025
Original Article by @TalIfargan et al.: Autonomous LLM-Driven Research — from Data to Human-Verifiable Research Papers nejm.ai/4f8JAPA #ArtificialIntelligence
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Lukas Hafner retweeted
Indeed, mistakes in research are inevitable, but the key is to leverage AI to address them more effectively and expose them transparently. We should harness AI to make science more reproducible and verifiable.
"Merely" having AI oversee study design and manuscript construction (much less than proposed in this article) would reduce errors that have led to irreproducible results and unintentionally misleading figures/tables.
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Lukas Hafner retweeted
6 Jan 2025
A study by @TalIfargan and colleagues demonstrates a potential for AI-driven acceleration of scientific discovery in biomedical research and beyond, while enhancing, rather than jeopardizing, traceability, transparency, and verifiability. nejm.ai/4f8JAPA
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Lukas Hafner retweeted
people in academia are way too negative about chatGPT, LLMs, etc.. why are folks so allergic to machine learning?
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Lukas Hafner retweeted
using the same color names, comparing different dimensionality reduction algorithms (pca, tsne and umap):
✨How AI sees colors: a color space made from their interconnected linguistic dimensions🌈 I extracted all the words for colors from wiki and mapped their embeddings from llms to a 3D color space, making it a semantic one purely derived from languages of the hive mind. 𓉤 #aiart #llm #touchdesigner #datavisualization #dataviz #audiovisual
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Lukas Hafner retweeted
It's so great to be knitting wire cells again, this time for a 32-cell snowflake yeast colony for @wc_ratcliff! 🦠 What a beautiful model organism that Will's lab uses to study the evolution of multicellularity. Stay tuned to see the sculpture grow! 😉 #sciart #snowflakeyeast
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How will AI reshape the way we publish and read papers? In 30 years, will there be such a thing as "a paper"? How will academia deal with it?
It's a safe bet that there will be a lot more capability (Science Goal/Question->AI->Data->Publication) in the same vein in the near future. Will pose interesting questions for academia and the publication-industrial-conplex immediately.
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Lukas Hafner retweeted
🎉 Big news! Our Nucleotide Transformer foundation models for genomics were just published in @naturemethods! 🚀 So proud of this incredible team @instadeepai! ⭐Paper: go.nature.com/3OA7dWr 📕Research briefing: go.nature.com/3BbSPQY
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Lukas Hafner retweeted
Agree with this and it’s not so different from the folks who complain AI will break something in science or the practice of it (usually something that’s already deeply broken or aggressively suboptimal)
The people freaking out about AI "destroying education" are telling on themselves. They're so indoctrinated by our Industrial Revolution-era factory model of education that they can't imagine alternatives. But every major technology - from books to electricity to the internet - has transformed how humans learn. If AI can do your homework, maybe homework isn't how we should measure learning anymore. The goal of education is to create lasting cognitive change - literally rewiring neural pathways as we master reading, writing, and analytical thinking. Our current system of standardized assignments and generic grading is just one deeply flawed path to that destination. When someone says "AI is great for learning but will destroy education," what they're really admitting is that our education system is broken and desperately needs disruption. The fact that so many educators can't envision alternatives proves how effectively this system has educated the creativity and vision right out of us. Time to break free.
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