Associate Professor @UVABME, PI for Laboratory of Systems Biology and Cancer Pharmacology, @UVACancerCenter, @MedicineUVA, @UVAEngineers. All views my own!
Joined May 2018
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6 Photos and videos
Happy to share preprint of our lab's latest work led by talented PhD student, Luisa Quesada at @UVABME and @UVACancerCenter , applying a systematic multivariate analysis of chromatin complex dependencies to reveal Set1C/COMPASS as a #melanoma-enriched epigenetic vulnerability.
Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a melanoma-enriched epigenetic vulnerability biorxiv.org/content/10.64898… #biorxiv_cancer
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We also report dependency on Set1C/COMPASS complex in melanoma. Via genetic perturbation, transcriptomics and single-cell analyses, we show that Set1C/COMPASS-dependent melanoma cells require this complex to maintain H3K4me3 and sustain MYC- and E2F-driven proliferative programs.
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Together, our findings illustrate how integrative computational analysis and multivariate modeling can uncover mechanistically meaningful chromatin vulnerabilities in cancer.
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Mohammad Fallahi-Sichani retweeted
Cancer cells have a dangerous superpower: the ability to change & adapt to resist treatment. UVA Biomedical Engineering Professor Mohammad Fallahi-Sichani is studying this "cell state plasticity" to develop therapies that could prevent resistance and metastasis. #ResearchInMotion
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It was a pleasure and great fun attending the CMBE meeting, presenting updates from our lab work on Cell State Plasticity and AP-1 network , led by @UVABME PhD student, Yonatan Degefu.
If you want to learn more about it, here is the link to the preprint:
pubmed.ncbi.nlm.nih.gov/4127…
Jan 5
🧬🧩 One network. Many cell states. Constant rewiring.
Mohammed Fallahi-Sichani @MFallahiSichani (UVA) shows how the AP-1 co-regulatory network organizes discrete, heterogeneous, and reconfigurable cell states.
Biology, built to adapt.
#CMBE2026 #SystemsBiology
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Mohammad Fallahi-Sichani retweeted
10 Nov 2025
Congratulations to the 2026 BMES CMBE Rising Stars! These outstanding early-career researchers are advancing the frontiers of cellular and molecular bioengineering.
See all honorees: bmes.org/awards/rising-stars…📷
#BMES #CMBE #RisingStars #Bioengineering
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10 Nov 2025
Excited to share our lab's latest work led by talented Yonatan Degefu, showing how cell state plasticity (in melanoma) is shaped by co-regulated, competitive, configurable interactions within the AP-1 transcription factor network.
@UVABME @UVACancerCenter
8 Nov 2025
Cell state plasticity emerging from co-regulated, competitive, and configurable interactions within the AP-1 network biorxiv.org/content/10.1101/… #biorxiv_sysbio
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8 Nov 2025
Excited to share our lab's latest work led by talented Yonatan Degefu, showing how cell state plasticity (in melanoma) is shaped by co-regulated, competitive, configurable interactions within the AP-1 transcription factor network.
@UVABME @UVACancerCenter biorxiv.org/content/10.1101/…
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8 Nov 2025
Under MAPK inhibition, the network adapts; loss of JUND, down-regulation of FRA1, and up-regulation of cJUN, promoting a FRA2-High state that drives dedifferentiation (loss of MITF and SOX10) and MAPK inhibitor resistance.
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8 Nov 2025
These findings link the mechanistic logic of AP-1 network wiring to a well-known adaptive resistance phenotype in melanoma and show how model-guided perturbations can block this transition.
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