🎆I am beyond thrilled to announce that I will be joining @Concordia Biology department as an Associate Professor in the Fall 2024! My Computational Genomics lab will use multi-omics to understand environmental and genetic contributions to human health. 🧬🧑💻
We are delighted to share the latest findings from the lab in Nature! We report mutation-dependent effects of sleep and exercise on clonal hematopoiesis (CH) and its associated atherosclerosis.
nature.com/articles/s41586-0…
Big progress vs cancer, folks.
The kind of event curves from randomized trials that we've not seen before for a couple of the most deadly cancers. Congrats to the oncology research community for getting these trial done. #ASCO26, @ASCO
Do not miss this incredible paper from David Fernandez Antoran's team (with some contribution from my team). The paper introduces epithelioids as a powerful 3D culture system for 8 different human tissues, for longitudinal in vitro studies of human epithelia. Great thread below.
Arguably the most boring step in genomics is the first one: normalization. Settled science. Scale log. Move on.
Except that here's been a huge blind spot in the field. And it matters for AIxBio. A 🧵about what I think may be one of the most important papers I've written. 1/
We also showed how mCAs impact blood transcriptomes, implicating stabilizing selection as a mechanism by which copy number gain mutations are tolerated in healthy blood.
Collectively, mapping the landscape of autosomal mCAs in populations of diverse ancestry illustrates similarities but also highlights important ancestry, geographic, and sex differences.
Big, beautiful trees!!
SMART-PTA for whole-genome transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
biorxiv.org/content/10.1101/…
Friends and colleagues, I’ve written a book on effective functional genomics study design, which will be available on Amazon in a couple of weeks. Sharing the TOC to spark interest. I hope students will find it useful! I’ll share updates soon
In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox:
For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?
Our lab has a #molecular lab assistant position available for the next several months that we are looking to fill asap. Flexible hours, part- or full-time. Come join a great team and work on some super cool #fish#genomics projects! @IKGenFisheries@Concordia