Dr. Eduardo Marban | Executive Director, Smidt Heart Institute @CedarsSinai Views are my own, not institutional policy!
Joined May 2021
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Working with @rrogerslab of Cedars-Sinai, Jonah Zarrow, PhD has developed new #exomers with RNase-resistant backbones & bioactivity against #DNA damage. Supported by our #T32 postdoctoral training grant from @NIH
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Honored to have been chosen as the 2026 Arthur C. Guyton Distinguished Visiting Professor in Physiology & Biophysics at @UMMCnews. Below, joining me in flanking the iconic portrait of Guyton, are George Souza, my gracious host John Hall & Ana Omoto.
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Sharing a thoughtful story from Cedars-Sinai on the discovery process that led to deramiocel for Duchenne cardiomyopathy. It’s been an amazing journey!
cedars-sinai.edu/health-scie…
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This is not only a loss to cardiology at large, but also a personal loss. Gene went out of his way to engage me and serve as a mentor over the years, even if at a distance. Our paper, "Training the Clinician Investigator", has some helpful pearls: ahajournals.org/doi/10.1161/…
The American Heart Association mourns the passing of the legendary cardiologist Eugene Braunwald, M.D., widely recognized as one of the most influential figures in the history of cardiovascular medicine. Over seven decades, his work reshaped the understanding and treatment of heart disease, leading many to call him the father of modern cardiology.
Braunwald was a lifelong contributor to the American Heart Association, helping advance its research and scientific mission, and was honored with some of the Association’s highest honors for his lasting influence on cardiovascular care and research. His influence extended well beyond his own discoveries, as generations of Association‑supported investigators, clinicians and academic leaders were trained by Braunwald or guided by the clinical trial standards and mentorship models he helped establish.
newsroom.heart.org/news/amer…
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This week’s lab meeting feat. @coralf_reef discussing his work w/James Dawkins & @EugenioCingolan on biological alternatives to ablation for #VT. Much promise to move from tissue destruction to tissue healing as a therapeutic strategy.
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We were pleased to host @kory_lavine of @washumedicine as @SmidtHeart visiting professor. Kory’s cutting edge work on innate immunity is identifying new #therapeutic targets for #heartfailure. @LavineLab
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#journalclub featured Adarsh Balaji @ke_liaoPhD & @TheIbrahimLab each reviewing novel #therapeutic interventions— self-amplifying #mRNA post-MI, “scarless” circular #RNA to improve CAR-T, & “flexomers” for Lewe body dementia & related synocleinopathies. Terrific presentations!
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Today’s #labmeeting featured Diana Kitka, mentored by @TheIbrahimLab, on myeloid cells and how they are altered by #exomer TY1 after #cardiac #ischemia. Elegant methodology leading to new insights!
@SmidtHeart
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We were delighted to welcome @SaumyaDas_Lab as @SmidtHeart research seminar speaker. Saumya reviewed his groundbreaking work on #tRNA fragments as regulators of #autophagy and potential therapeutic candidates.
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Informative #labmeeting today by @ginachen_jiahui on biomaterial-based approaches to a major unmet medical need: #adhesions after abdominal #surgery. Definite need for new adjunctive measures to prevent!
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Stimulating @SmidtHeart research seminar today by Prof Na Li of @BaylorMedicine on atrial fibrillation and its relationship to the #inflammasome. 👍👏🙏
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Thanks for your hospitality Oscar!
Stellar presentation at @hopkinsheart Grand Rounds by @MarbanLab from @SmidtHeart. From cardiac cell therapy to novel RNA. Great to have you back!
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Looking forward to visiting my old hunting grounds @HopkinsMedicine — where I spent 25 years from #oslerpride intern through Chief of Cardiology (@hopkinsheart) before founding @SmidtHeart. I’ll discuss the nonlinear arc from Deramiocel for #Duchenne to #exomers. @TheIbrahimLab
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TY2 is our second #ncRNA #drug in clinical development based on the #CREDO discovery paradigm— this one is amazingly potent and effective in clearing #interstitial #debris! Work supported by @CIRMnews
Mar 16
This Research Letter offers a creative approach to #sepsis based on a naturally occurring efferocytosis-enhancing RNA
doi.org/10.1172/jci.insight.…
Small noncoding RNA TY2 enhances efferocytosis and improves outcomes in a mouse model of sepsis by @AleCiulloPhD, @Marbanlab, @TheIbrahimlab & team @CedarsSinai.
The image shows exposure to TY2 increases E. coli clearance by bone-marrow derived macrophages as indicated by fluorophore as a reporter of efferocytosis (green).
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Eduardo Marban, MD, PhD retweeted
Mar 16
Behind the scenes: Ciullo and team develop an exomer drug based on a naturally occurring RNA and investigate its bioactivity in acute sepsis.
@AleCiulloPhD @TheIbrahimLab @MarbanLab @Kara_tsi @anhhnguyennn9 @Hiroaki_komuro @XMichaelJonesMD @SmidtHeart
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Today’s lab meeting featured @joshuagoco testing of #TREX1-enhancing #exomer TY1 on chronic #MI in mice. TY1 given 3 weeks post-MI improved function and volumes despite the chronicity of injury— does mitochondrial DNA scavenging underlie MoA? Happy travels Josh!
@TheIbrahimLab
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15 years ago, I urged postdoc @MarkAmin2019 to test allogeneic #CDCs in #mdx mice to see if they ameliorate #Duchenne #cardiomyopathy. Flash forward: #Deramiocel dramatically preserves both heart and skeletal muscle function in #DMD patients as Craig McDonald shows today #MDAorg!
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It was our pleasure to host @DanKellyPennCVI as @SmidtHeart research seminar speaker and visiting professor. Remember all those #metabolic pathways that tortured us in biochem? Well, they turn out to modulate #cardiac maturation and heart failure. Lots of great discussions!
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Eduardo Marban, MD, PhD retweeted
Mar 6
Wanted to post this article from Cedars-Sinai (penned by Kristin Reynolds) remembering my dear friend, Kiel Allen Peck and the lasting contributions he made to translational medicine and the lucky people who knew him.
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