@MariaDonde2 profile picture
Maria Jose Donde @MariaDonde2

Wellcome Trust PhD student developing XNA precision medicine 🧬 Taylor lab, University of Cambridge

Joined October 2020
  • Tweets 18
  • Following 80
  • Followers 38
2 Photos and videos
Maria Jose Donde retweeted
Megan Gozzard@PhDood1es
27 Oct 2024
What geneticists fear the most: The Cambridge Plot.
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Maria Jose Donde retweeted
Megan Gozzard@PhDood1es
11 May 2023
Really enjoyed illustrating for the @sangerinstitute blog reporting the publication of the first draft #pangenome ✏️
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Maria Jose Donde retweeted
Alex Taylor@Taylor_Lab_KCL
2 May 2023
Very well deserved congratulations to my student @MariaDonde2 who has won one of this years’ PhD student awards from the Cambridge Society for the Application of Research (CSAR) for her work on XNAzymes! Well done Maria! csar.org.uk/student-awards/2…
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Maria Jose Donde retweeted
Jake Thomas@JakerrThomas
30 Mar 2023
Excited to see this work from my PhD with @McGovernLab finally out! The revised study now includes fascinating epigenetics data from @annappios and @cw_hanna showing how HLA class II expression is initially silenced in human primitive macrophages. Check it out! 👇
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I am very excited to share the new paper from the lab. We are using XNAzymes to cleave SARScoV2 ✂️ Many congrats to @Taylor_Lab_Cam for getting big part of this done while on lockdown!
Alex Taylor@Taylor_Lab_KCL
16 Nov 2022
🚨Paper in @NatureComms w/ @pehuen87 #COVID19 hit as I started my lab, so I explored the potential of artificial enzymes to target #SARSCoV2 RNA, engineering catalytic nanostructures to chop the genome & inhibit #coronavirus replication in cells #synbio nature.com/articles/s41467-0…
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Maria Jose Donde retweeted
Katharina Zühlsdorff@katha_zuehli
15 Nov 2022
Have you ever wondered what the neural substrates of changing your mind are? 🤔🧠 find out in our new article: doi.org/10.1093/cercor/bhac4… @MoreinLab @CamNeuro

Cognitive flexibility: neurobehavioral correlates of changing one’s mind

Abstract. Behavioral and cognitive flexibility allow adaptation to a changing environment. Most tasks used to investigate flexibility require switching rea

academic.oup.com
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Maria Jose Donde retweeted
Alex Taylor@Taylor_Lab_KCL
18 Oct 2022
Formal at @MECCambridge with my brilliant PhDs @MariaDonde2 & @g_dhaliwal1 - Thank you X-women
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Maria Jose Donde retweeted
Niklas Freund@Niklas_Freund1
13 Oct 2022
Proud to announce that my first first-author paper is online! We (@Taylor_Lab_Cam, @PhilHolliger and our co-workers) demonstrate how a novel engineered polymerase unlocks efficient synthesis and evolution of therapeutic 2'-modified nucleic acids. nature.com/articles/s41557-0… 🧵(1/n)

A two-residue nascent-strand steric gate controls synthesis of 2′-O-methyl- and 2′-O-(2-methoxyet...

Nature Chemistry - Sterically demanding 2′-modified nucleotides used in antisense therapeutics have thus far been challenging to synthesise enzymatically. Now, it has been shown that mutation...

nature.com
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Maria Jose Donde retweeted
Communications Biology@CommsBio
24 Sep 2022
Engineered RNA endonuclease XNAzymes can specifically target individual disease-associated ncRNAs in vitro, with the potential for precision detection or knockdown of individual microRNAs or longer ncRNAs. @Taylor_Lab_Cam @MariaDonde2 @Cambridge_Uni nature.com/articles/s42003-0…
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Check out our new paper showing how we re-targeted XNAzymes to cleave individual miR and Y RNA! Thanks to everyone involded and especially @Taylor_Lab_Cam.
Alex Taylor@Taylor_Lab_KCL
24 Sep 2022
🚨 New paper in @CommsBio by brilliant student @MariaDonde2 ! We engineer XNAzymes to selectively cleave individual disease-associated non-coding RNAs (microRNAs, Y RNA) in families of similar seqs – a route to precision modulation of RNA networks? #synbio rdcu.be/cWfuE
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Maria Jose Donde retweeted
Alex Taylor@Taylor_Lab_KCL
5 Sep 2022
🚨Article in @NatureChemistry w/ @PhilHolliger @ChrisJWan Using test tube evolution of synthetic nucleic acids we engineer artificial RNA-cutting oligo enzymes that cleave transcripts in cells w/single-nucleotide precision #synbio chemistrycommunity.nature.co… & nature.com/articles/s41557-0…

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Maria Jose Donde retweeted
Alex Taylor@Taylor_Lab_KCL
30 Aug 2022
Delighted to share this new paper w/ @JackHervey - front cover of @rsc_chembio ! Here, we develop & evaluate systems for synthesis of pure & mixed-chemistry synthetic oligo libraries, paving the way to directed evolution of fully-biostable polymers #synbio doi.org/10.1039/D2CB00035K
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Maria Jose Donde retweeted
Alex Taylor@Taylor_Lab_KCL
18 Jul 2022
I’ve published a ‘Matters Arising’ article in @NatureChemistry in collab with @PhilHolliger in which we examine a modified version of the 10-23 DNAzyme, “X10-23”, described by the labs of Profs. John Chaput and Robert Spitale (UC Irvine) – A thread (1/10) nature.com/articles/s41557-0…

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Please support us this Sunday as we run the Cambridge 1/2 Marathon for @teamaruk ! Please donate below👇 justgiving.com/fundraising/n… Only a few pounds can go a long way.... like buying one of these tubes or paying the PhD student holding them yearly stipend !
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Maria Jose Donde retweeted
Jake Thomas@JakerrThomas
28 Feb 2022
Ever wondered how Hofbauer cells (human fetal placental macrophages) are generated during pregnancy? We aimed to investigate this in our latest preprint! biorxiv.org/content/10.1101/…

Human HLFneg placental erythro-myeloid progenitors give rise to HLA Class IIneg Hofbauer cells

The earliest macrophages are generated during embryonic development from erythro-myeloid progenitors (EMPs) via primitive haematopoiesis. This process is still poorly understood in humans but is...

biorxiv.org
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Maria Jose Donde retweeted
Alex Taylor@Taylor_Lab_KCL
13 Dec 2020
🚨 Interested in a @Cambridge_Uni PhD? Think synthetic biology, artificial oligonucleotides & precision medicines sound cool? Come join the Taylor lab!👽🧬 Applications now open for Oct 2021 entry to a new PhD prog in infection & immunity citiid.cam.ac.uk/students/ RTs appreciated!
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