Senior Lecturer in Respiratory Medicine @OfficialUoM Precision medicine in #COPD & #AECOPD, Clinical #Trials, #Guidelines, #EBM.
Joined June 2011
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Thank you to the @HCPLiveNews editorial team and @ChelsieDerman for the opportunity to discuss this work.
💡In a FLAME post-hoc analysis we found 3-month withdrawal effects on COPD exacerbations after ICS or LAMA discontinuation.
🔗 hcplive.com/view/copd-drug-w…
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That is a rigorous review!!
Apr 29
I’m starting to think our manuscript at BMC Cardiovascular Journal didn’t go out for peer review. It went on a world tour. 😆
The editor didn’t just invite reviewers, they basically launched an open call to the entire cardiovascular community 😄
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MathioudakisAG retweeted
Apr 28
🚭 ERS urges other countries to follow the example of the United Kingdom (UK) after it announced a generational sales ban on tobacco.
Read more: ersnet.org/news-and-features…
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MathioudakisAG retweeted
@victoriachgr Dr Victoria Chatzimavridou gave us a fascinating run through of her work on pelvic insufficiency fractures caused by radiotherapy. #BoneUp #ECTS26
I’m seeing more and more referrals like this to the clinic
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🚨 Clinical academics undertake years of additional research training — but this is not recognised in NHS consultant pay progression.
This creates a structural inconsistency → ~£72,000–£81,000 lifetime loss per research year during training.
📖academic.oup.com/qjmed/advan…
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🎯At a time when the UK is seeking to strengthen its life sciences sector and reverse declining numbers of medical academics, pay arrangements should support — not discourage — doctors from undertaking research training.
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Big thanks to @TheBMA @BMA_Academics @gibb_jonathan @DocStrain for sharing these findings with @wesstreeting and other stakeholders. We hope this inconsistency will now be reviewed and addressed.
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MathioudakisAG retweeted
ERR: This meta-analysis (111 studies) quantifies viral prevalence in acute/stable asthma in children and adults, and highlights links between specific viruses and acute asthma severity. PCR alone may be limited in identifying viral acute asthma triggers. bit.ly/4ts91DT
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MathioudakisAG retweeted
Apr 15
This article in @AnnalsofIM highlights ethical problems in stopping trials early for benefit: seriously inflated overestimates of treatment effect violates ethical requirements of scientific validity and social value and leads to misguided patient choices.
pubmed.ncbi.nlm.nih.gov/1757…
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Great to see our work featured by @ChestPhysician .
Discontinuing LAMA or ICS in COPD is not neutral—there is a transient spike in exacerbation risk (~2x) for 3 months, consistent with withdrawal effects.
chestphysician.org/effects-o…
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#LAMA and #ICS are both associated with significant withdrawal effects.
Important implications for practice, adherence, and trial interpretation.
Here is our independent post-hoc analysis of FLAME trial: thorax.bmj.com/content/early…
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MathioudakisAG retweeted
Apr 13
Redundancies, retirement and funding cuts threaten the UK’s global standing in medical research as fewer NHS doctors can secure posts as clinical academics. Government inaction to address this loss of talent risks harming patient care and the UK’s economic future.
The number of medical academics has flatlined. This situation is threatening the UK’s global standing in medical research as fewer NHS consultants can secure posts as clinical academics.
Governments must act now.
Read about the crisis The Times
thetimes.com/article/be782e7…
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🚨 Our new meta-analysis quantifies the prevalence of respiratory viruses in both stable and acute asthma, across children and adults.
👉 Based on 111 studies
Just published in European Respiratory Review (ERS Publications):
doi.org/10.1183/16000617.017…
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• Rhinovirus is the most frequently identified pathogen in acute and stable asthma, both in adults and children.
• Certain viruses (e.g. influenza, adenovirus) may be linked to more severe attacks.
doi.org/10.1183/16000617.017…
@ManchesterBRC
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Big thanks to all the team that made this work possible and especially to @DrSachinAnanth & Juli Alimani.
@CristinaBoccabe @KateKhaleva @VirtueOfNothing @Ran_Wang_UoM @ProfGRoberts @ckosmidis Apostolos Bossios, Jørgen Vestbo, Effie Papageorgiou @ngpdoc @Beloukas
@UoM_DIIIRM
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The UK is rapidly losing medical academics and we need urgent action to reverse the decline. The Government needs to deliver a fair offer for medical academics training in England. We stand in solidarity with the UK resident doctors committee who have voted to reject the Government’s offer, which falls short in addressing the pay loss built into academic training.
Read our full letter from Medical Academics to the Secretary of State here.
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MathioudakisAG retweeted
Mar 31
Financial disadvantages built into academic training are driving resident doctors away from careers in research and education. It is precisely this structural mismatch that has fuelled the decline in medical academics. The Government must deliver a fair offer.
The UK is rapidly losing medical academics and we need urgent action to reverse the decline. The Government needs to deliver a fair offer for medical academics training in England. We stand in solidarity with the UK resident doctors committee who have voted to reject the Government’s offer, which falls short in addressing the pay loss built into academic training.
Read our full letter from Medical Academics to the Secretary of State here.
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MathioudakisAG retweeted
🫁 Stopping COPD inhalers can lead to higher risk of flare-ups for 3 months.
Read about this Manchester BRC supported study led by Dr @MathioudakisAG in the February BRC news round-up 👇
📰 18 NIHR BRCs news stories from Feb 2026!
From UK-first studies tackling children’s asthma inhaler overuse to pioneering surgery for post-stroke pain, plus breakthroughs in cancer, COPD & mental health — February was packed with research making a real difference.
🎥 Watch & read more: linkedin.com/pulse/nihr-brcs…
📩 Subscribe for monthly LinkedIn roundups: linkedin.com/build-relation/…
👇 Read the thread below to visit each news story
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MathioudakisAG retweeted
📰 Stopping long-acting inhalers for COPD can lead to a sharp rise in flare-ups for 3 months, new research has revealed.
The Manchester BRC-supported study was led by Dr @MathioudakisAG from our Respiratory Theme. 🫁
Read more 👇
manchesterbrc.nihr.ac.uk/new…
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