On regeneration, ageing and the control of cellular plasticity
Joined November 2021
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Pinned Tweet
13 Jun 2025
🌟 WE ARE HIRING! 🌟
Principles of Regeneration and Ageing in a cutting edge science-driven environment & core funding
Outstanding POSTDOCS; BIOINFORMATICIANS & RAs: join us at CIMR-Chinese Institutes for Medical Research, Beijing.
APPLY here: theyunlab.com/ Please RT
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Apr 16
Check out our latest preprint, where we show that adaptive immunity is dispensable for appendage regeneration in super regenerators, axolotl & zebrafish! : biorxiv.org/content/10.64898… thanks to Lizbeth, all authors and our collab Knopf lab
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The Chinese government is ramping up its support for science
go.nature.com/4lsG479
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Feb 21
New Year, New Paper for the Yun Lab! 🌟We find that Axolotls exhibit limited reproductive senescence and retain fertility throughout lifespan (pubmed.ncbi.nlm.nih.gov/4168…). Kudos to Yuliia Haluza, in this great collab with @Tanaxolotl
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Feb 21
Remarkably, they preserve early stage oocytes until advance ages, with old females spawning large numbers of viable larvae within the average lifespan. Interestingly they show follicular atresia concomitant with enlargement of egg size in late ages, likely a resilience strategy
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Feb 21
This study provides new insights into axolotl age resilience and offers a model for understanding how long-lived vertebrates maintain reproductive capacity through 🕰️
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TheYunLab retweeted
Jan 11
#CMMDR2026 was lovely & fun: great science, inspiring discussions, and grateful for the invitation to give a talk & chair a session.
Huge congrats to the organisers!
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Jan 7
First time in India, great science, food and friends.
#CMMDR26 has begun!✨
The Conference on Molecular Mechanisms in Development & Regeneration (6–9 Jan), opened with remarks by Dr Sanjeev Galande and a great first talk by Dr Maximina Yun on salamander models of #regeneration & aging.
Stay tuned!
#DevelopmentalBiology
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TheYunLab retweeted
24 Dec 2025
Research we covered in our #ARDD2025 field notes (linked below) is now published.
@MaxYunLab showed axolotls can regenerate their thymus de novo after complete removal. Not partial regrowth from remnants like mammals can often manage, but full reconstruction.
FOXN1, the transcription factor mammals need for thymus development, turns out to be dispensable for axolotl thymus regeneration. Midkine signaling appears to drive it instead.
This is relevant for longevity because in mammals, the thymus shrinks with age, taking T cell production and immune function with it. Axolotls skip this process entirely, maintaining their thymus throughout life with roughly flat mortality risk.
Understanding how they pull that off could eventually point toward ways to restore thymic function in aging humans.
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TheYunLab retweeted
10 Dec 2025
The growth factor #midkine, but not the transcription factor Foxn1, may drive #thymus regeneration following complete removal of the organ in juvenile axolotls.
Learn more in Science #Immunology: scim.ag/4pih6Zw
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TheYunLab retweeted
11 Dec 2025
Very proud of organizing the EMBO Regeneration Workshop 2026 in Krems, in the heart of Austria, together with @simoesfili, Anna Jazwinska, @solana_jordi, Mansi Srivastava, @MaxYunLab and Juanma González-Rosa! #EMBORegeneration Registration is now open!
meetings.embo.org/event/26-t…
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7 Dec 2025
Alert: Our finding that axolotls regenerate their thymus de novo is out! science.org/doi/10.1126/scii…. A fantastic collab with @MaehrLab kudos to @aniaczark @MacrinaLobo Liz Bolaños Castro @fabianrost84 @DcGenomeCenter CIMR Beijing @PoLDresden @mpicbg , & @ClaireOlingy for editing
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7 Dec 2025
Instead, #Midkine (MDK) and BMP signaling is required. MDK is a critical early trigger without which there is no regrowth
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10 Dec 2025
Thanks to @ScienceMagazine for featuring our work: science.org/topic/article-ty… kudos to Christie Wilcox. @MaehrLab
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TheYunLab retweeted
4 Dec 2025
Check out our workshop on mechanisms by which 1D and 3D processes are integrated in the genome: lnkd.in/d_CtRpna. I am organizing this with Buddhapriya Chakrabarti, Srinjan Basu and Angelo Rosa. #epigenetics #genomics #physics #chromatin #genomeorganization
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17 Nov 2025
Great update by Brian Kennedy on the state and future of Ageing science in Singapore at HealthyLongevityMedicine Conference 2025
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