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McFadden Lab @McFaddenLab

We use genetic and chemical screening approaches to study thyroid cancer, Ewing sarcoma and neuroendocrine tumors.

Joined November 2021
  • Tweets 15
  • Following 79
  • Followers 219
4 Photos and videos
Our latest preprint is online. Thanks to many in the lab for contributing to building these cell lines over the years including James’ and Alberto’s key contributions. biorxiv.org/content/10.1101/…

Endogenous EWSR1-FLI1 degron alleles enable control of fusion oncoprotein expression in tumor cell...

Pediatric malignancies frequently harbor chromosomal translocations that induce expression of fusion oncoproteins. The EWSR1-FLI1 fusion oncoprotein acts as a neomorphic transcription factor and is...

biorxiv.org
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Beautiful full moon rising over Pegasus Park last night! The group celebrated our physical move to @UTSW_RadOnc lab space in the new Section of Molecular Medicine headed by Deepak Nijhawan. @CommunityBeerCo @BioLabsNTX
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Former student @afrank0410's latest work out today in ACS Chemical Biology. pubs.acs.org/doi/10.1021/acs…. He used a method we reported in 2019 to engineer hypermutation into cancer cell lines to find compound-resistant alleles to an LDH inhibitor. Great work Anderson!

Forward Genetic Screens Identify Mechanisms of Resistance to Small-Molecule Lactate Dehydrogenase...

Altered metabolism is a hallmark of cancer; however, it has been difficult to specifically target metabolism in cancer for therapeutic benefit. Cancers with genetically defined defects in metabolic...

pubs.acs.org
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Link to 2019 paper describing the forward genetics approach from @PovedanoJuanma in @CellChemBiol: sciencedirect.com/science/ar….
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Great fun with the lab at Top Golf this afternoon celebrating Haden’s time in the lab. He is off to graduate studies in physics!
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I also want to specifically thank @DamonRunyon for funding us when this project was in its infancy.
Cancer Discovery@CD_AACR
2 Jun 2023
Mitochondrial-encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid, by Anderson Frank, @McFaddenLab et al. bit.ly/42olvOd @UTSWNews
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Very proud of Anderson and his manuscript. I look forward to more great science from him as a postdoc with @SueBiggins at @fredhutch. Great work Anderson! This manuscript a product of Anderson's hard work and persistence and the scientific environment here @UTSWNews
Elizabeth McKenna@ElizSMcKenna
1 Jun 2023
It's #metabolism day at @CD_AACR! Now online: Mitochondrial-encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in #HürthleCellCarcinoma of the Thyroid by Anderson Frank, @McFaddenLab, and colleagues @UTSWNews doi.org/10.1158/2159-8290.CD…
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Research Scientist application link: jobs.utsouthwestern.edu/job/…
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Research Technician application link: jobs.utsouthwestern.edu/job/…
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New positions for 2023 open in the McFadden Lab for a research technician to work for 1-2 years prior to graduate/medical school and a research scientist with an interest in small molecule screening, CRISPR genetic screens, biochemistry, metabolism. Links to follow.
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James from the lab delivered an awesome talk today at the NCI FusOnc2 Annual meeting! Great job!
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Latest work from the lab out on BioRxiv from stellar student Anderson…we missed you at the CSHL meeting! biorxiv.org/cgi/content/shor…
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Back from CSHL mechanisms and models meeting. Great fun with Vicky, @PovedanoJuanma, and James from the lab, and seeing many friends and colleagues!
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Our latest manuscript is online @CellChemBiol. Congrats to @PovedanoJuanma and the rest of the lab team on this work identifying the mechanism of cytotoxicity for TK216 that was in clinical trials for Ewing sarcoma. authors.elsevier.com/sd/arti…

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We have finally caved to the pressure and the McFadden Lab has joined Twitter! More to come...
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