Engineering Ashbya gossypii for precision fermentation of high-value metabolites via metabolic & protein engineering through structural & functional studies.
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ALT Figure showing the biosynthetic pathway of ganglioside GD3. At the top, the chemical structure of GD3 is displayed. The molecule consists of three main components: a ceramide backbone (brown, right), composed of a sphingosine base linked to a fatty acid; an oligosaccharide chain (green), containing glucose, galactose, and N-acetylglucosamine residues; and two terminal sialic acid residues (pink, left), typically N-acetylneuraminic acid. Below, a schematic pathway depicts GD3 biosynthesis, including the conversion of glucosylceramide (GlcCer) to lactosylceramide (LacCer), followed by the sequential addition of one and then two sialic acid groups to produce gangliosides GM3 and GD3, respectively.
ALT Presenting my poster: "Fragment-Based Discovery of Inhibitors Targeting the Unique Cyanobacterial IMP Dehydrogenase GuaB3" at the 47th SEBBM Congress.
ALT Delivering my talk: "Crystallographic Fragment Screening to Identify Inhibitors of GuaB3, a Unique Cyanobacterial IMPDH" at the 47th SEBBM Congress.
ALT Explaining the impact of cyanobacterial blooms and introducing our target enzyme GuaB3 during my oral presentation at the 47th SEBBM Congress.
ALT Standing with the official 47th SEBBM Congress poster.
