@MillerLabMIT profile picture
Earl K. Miller @MillerLabMIT
Joined May 2011
  • Tweets 10,698
  • Following 1,745
  • Followers 45,808
724 Photos and videos
Macroscale traveling waves link perception, response selection, and vocal production during marmoset vocal interactions doi.org/10.64898/2026.05.15.… #neuroscience

Macroscale traveling waves link perception, response selection, and vocal production during...

Vocal communication involves a series of cognitive processes, which can be broadly categorized into three components: perceiving communicative signals; deciding whether and how to respond; and...

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Neural synchrony between prefrontal and visual cortex supports visual working memory doi.org/10.64898/2026.06.05.… #neuroscience

Neural synchrony between prefrontal and visual cortex supports visual working memory

Working memory appears to depend on neural mechanisms that are distributed across the brain. Specifically, neural activity persists in the prefrontal cortex while memories are maintained, and at the...

biorxiv.org
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Earl K. Miller retweeted
General Bonkers@GenBonks
19h
Bonkers has been on hiatus, getting his paw fixed. But a new release is coming soon. In the meantime, enjoy our "This is General Bonkers" playlist. open.spotify.com/playlist/1w…

This is General Bonkers

Playlist · EKM · 10 items

open.spotify.com
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Sheila Macrine, Ph.D.
@MacrinePhD
Jun 13
How does the brain turn brief experiences into long-lasting moods or habits? New preprint from the Flavell Lab at @mitbrainandcog deconstructs an aversive behavioral state in C. elegans (Roundworms-nematodes). By mapping whole-brain dynamics during repeated negative encounters, the team discovered that a global state isn’t controlled by a single master hub. Instead, it is broken down into distinct features (like speed vs. sensory priming) controlled by parallel neural integrators (ADA, AVH, and PVQ) acting on different timescales. While AVH relies on circuit-level feedback to drive sustained locomotion speed, PVQ uses cell-intrinsic persistence to prime the animal for future threats. H/T @MillerLabMIT doi.org/10.64898/2026.06.04.… #Neuroscience #Celegans #BrainConnectomics #SystemsNeuroscience #NeuralCircuits #Biophysics

Deconstructing a behavioral state: parallel neural integrators control distinct features of an...

Transient sensory stimuli can trigger long-lasting changes in behavior and cognition. For example, repeated aversive experiences can lead to persistent changes in arousal and mood. Specialized...

biorxiv.org
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Earl K. Miller retweeted
Sheila Macrine, Ph.D.
@MacrinePhD
Jun 13
Is categorization something the brain does after perceiving the world, or is it how perception happens in the first place? A groundbreaking Perspective by Lisa Feldman Barrett and Earl K. Miller in Nature Reviews Neuroscienceargues that categorization is completely "baked" into our neural infrastructure. Rather than a final-stage sorting process, categorization occurs from the very moment a sensory signal enters the brain. Driven by predictive feedback loops that start at the limbic core, the brain continuously constructs functional context to optimize energy and anticipate metabolic needs (allostasis). In short: meaning and metabolism are deeply intertwined, and your brain is constantly grouping the world to keep your body running efficiently. @MillerLabMIT doi.org/10.1038/s41583-026-0… #Neuroscience #CognitiveScience #BrainResearch #Categorization #Allostasis #PredictiveProcessing #Neuroanatomy

Categorization is ‘baked’ into the brain

Nature Reviews Neuroscience - Categorization, the grouping of objects, living organisms, actions or events into equivalence clusters, is fundamental to adaptive behaviour. In this Perspective,...

nature.com
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Earl K. Miller retweeted
MIT Picower Institute@MIT_Picower
Jun 11
How do brains integrate sensory evidence over minutes to generate adaptive behaviors? A new Flavell lab preprint identifies C. elegans circuits that integrate aversive smells during foraging to control specific behavioral responses. biorxiv.org/content/10.64898… #neuroscience
A grayscale image shows a worm slithering from the upper right to the bottom left. It's head crosses a faint line labeled "copper boundary."

ALT A grayscale image shows a worm slithering from the upper right to the bottom left. It's head crosses a faint line labeled "copper boundary."
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New results! Mechanistic corticostriatal circuit model predicts learning-dependent fMRI dynamics and individual reward bias in humans doi.org/10.64898/2026.05.28.… #neuroscience #neuroblox

Mechanistic corticostriatal circuit model predicts learning-dependent fMRI dynamics and individual...

Circuit-level computational models can do more than explain existing data; they can generate novel hypotheses and capture individual differences in human populations. We demonstrate this using a...

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Correction: June *11* 8pm, I will give the PSW public science lecture at the Cosmos Club in DC And you (yes, you) can watch online: pswscience.org/meeting/2537/ Thought Emerges from Neural Dynamics How Science is Unraveling the Nature of Cognition and Consciousness. #neuroscience

Thought Emerges from Neural Dynamics - How Science is Unraveling the Nature of Cognition and...

pswscience.org
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Congratulations to the newly minted *Dr.* Adam Eisen. He has that new Ph.D. smell. @adamjeisen @MIT_Picower
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And check out his wicked cool work on anesthesia: Similar destabilization of neural dynamics under different general anesthetics, Cell Reports, doi.org/10.1016/j.celrep.202… Propofol anesthesia destabilizes neural dynamics across cortex, Neuron doi.org/10.1016/j.neuron.202…

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New results! The prefrontal cortex uses a low-dimensional “coding space”. Info can be captured in just 3–6 dimensions. The brain compresses what we remember. Low-dimensional prefrontal representations of objects during working memory doi.org/10.64898/2026.06.03.… #neuroscience

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This results from a continual reduction in dimensionality and the organization of incoming signals via predictive feedback. nature.com/articles/s41583-0…

Categorization is ‘baked’ into the brain

Nature Reviews Neuroscience - Categorization, the grouping of objects, living organisms, actions or events into equivalence clusters, is fundamental to adaptive behaviour. In this Perspective,...

nature.com
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The cortex is not best understood as a set of fully separate, self-contained modules. Instead, regions work together in a more integrated, network-like way. Brain-wide distributed processing underlying natural vision and audition doi.org/10.64898/2026.05.26.… #neuroscience

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Earl K. Miller retweeted
Evan McGloughlin
@evan_mcgl
Jun 5
Michael Levin & Earl Miller: Platonic Space of Minds, Bioelectricity, Cell Intelligence & Neurobots Youtube: youtu.be/6mU5nN5nlLA Spotify: open.spotify.com/episode/6qJ… Skool Ad Free: skool.com/the-giants-shoulde…
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MIT Picower Institute@MIT_Picower
May 15
🐈Amid finals and in advance of graduation, two of our most prestigious 'Purr-fessors,' Kinje and Torbie, held office hours at a cat cafe today, arranged the lab of Professor Myriam Heiman. Attendees also enjoyed boba, macarons and cat crafts. Thanks to @mitscience, @mit_bcs
A bund of people stand around a conference room table that is stacked with boba teas

ALT A bund of people stand around a conference room table that is stacked with boba teas

Close-up on the hands of a man as he colors in a wooden cat with a magic marker

ALT Close-up on the hands of a man as he colors in a wooden cat with a magic marker

A multi-colored cat stands on a cat tree while being petted by two adoring onlookers

ALT A multi-colored cat stands on a cat tree while being petted by two adoring onlookers

A man in a grey MIT hat leans over to offer a treat to a dark grey cat in the recess of a fuzzy box

ALT A man in a grey MIT hat leans over to offer a treat to a dark grey cat in the recess of a fuzzy box
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Earl K. Miller retweeted
Drew B. Headley@DrewBHeadley
Jun 1
How do beta and gamma rhythms impact synaptic integration in pyramidal neurons? Our latest paper that examines this question studied this using a biophysically detailed pyramidal neuron model. Here’s what we found. A 🧵below. elifesciences.org/articles/9… 1/10
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New results! Theta rhythms flexibly routing information based on behavior and feedback, organizing local and long-range neural communication. Theta gates and routes information in the frontal cortex doi.org/10.64898/2026.06.03.… #neuroscience

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Beta rhythms sending top-down feedback to refine perception. Olfactory bulb-cortex oscillations encode perceived odor intensity rather than concentration journals.plos.org/plosbiolog… #neuroscience

Olfactory bulb-cortex oscillations encode perceived odor intensity rather than concentration

Some smells can seem stronger than others despite equivalent odor concentrations, but how does this occur? This study shows that coordinated neural activity between the human olfactory bulb and...

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Thalamic recordings show a rhythm that’s strong in wake and REM and absent in deep sleep: An electrophysiological signature of conscious states. nature.com/articles/s41562-0… #neuroscience

Thalamic oscillations distinguish natural states of consciousness in humans

Nature Human Behaviour - Chowdhury et al. report the discovery of a 19–45-Hz thalamic oscillation that is present during human wakefulness and REM sleep, but not NREM sleep.

nature.com
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Earl K. Miller retweeted
Luiz Pessoa@PessoaBrain
May 28
*Thalamic oscillations differentiate sleep stages (consciousness states)* Unusual chance to record from human neurons. nature.com/articles/s41562-0…

Thalamic oscillations distinguish natural states of consciousness in humans

Nature Human Behaviour - Chowdhury et al. report the discovery of a 19–45-Hz thalamic oscillation that is present during human wakefulness and REM sleep, but not NREM sleep.

nature.com
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