Cell biologist, Mechanistic dissection of protein folding, quality control, degradation, UPR, and ER-phagy pathways. Non sono direttore di giornale. My opinions
Joined November 2017
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85 Photos and videos
maurizio molinari retweeted
Jun 8
𝟏𝟗𝟒𝟏 – 𝟐𝟎𝟐𝟔 | 𝐂𝐚𝐦𝐩𝐢𝐨𝐧𝐢 𝐒𝐯𝐢𝐳𝐳𝐞𝐫𝐢 🏆
85 anni fa abbiamo scritto una pagina indimenticabile della nostra storia. Con il pareggio casalingo contro i rivali nella corsa al titolo, il BSC Young Boys, abbiamo conquistato il secondo titolo di Campione svizzero.
85 anni di memoria, passione e appartenenza 🤍🖤 ✨
#noibianconeri #fclugano #lug
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30 Oct 2025
News on ERLAD: Calnexin:FAM134B:VAPA:ORP1L:RAB7 contact site between ER and endolysosomes to remove misfolded proteins.
CNX:FAM134B-driven ERLAD of ATZ polymers proceeds via enhanced formation of VAPA:ORP1L:RAB7 contact sites between ER and endolysosomes tandfonline.com/doi/epdf/10.…
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13 Sep 2025
Today’s NCB. The cytoplasmic intrinsically disordered regions (IDRs) of ER-phagy and mitophagy receptors are interchangeable, required and sufficient for the ER and mitochondria fragmentation required for lysosomal clearance of the organelle’s portions.
rdcu.be/eF5DR
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4 Aug 2025
Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL
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9 Jul 2025
ATZ polymers elicit intervention of the CNX:FAM134B-LC3II segregation complex and formation of VAPA-ORP1L-RAB7 membrane contact sites that facilitate Syntaxin18/VAMP8-driven fusion of ER and endolysosomal membrane: ER-to-Lysosome-Associated Degradation.
biorxiv.org/content/10.1101/…
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2 Jul 2025
I would like to warmly thank the ALPHA-1 Foundation for the important support allocated to our research project “Understanding the Molecular Mechanisms of Lysosomal Clearance of ATZ Polymers".
A1F recognizes 2025 Grant Award Recipients during ATS alpha1.org/a1f-recognizes-20…
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maurizio molinari retweeted
23 Jun 2025
New Online! Key challenges and recommendations for defining organelle membrane contact sites bit.ly/4lnIBP1
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🚨 New review out in Nature Reviews Molecular Cell Biology!
Expert recommendations for studying organelle contact sites and introduce the concept of organelle contactome 🧬nature.com/articles/s41580-0…
Huge thanks to editor Lisa Heinke for the support and guidance! 🙏@NatRevMCB
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maurizio molinari retweeted
21 Jun 2025
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12 Jun 2025
Early morning discussion about see turtles with Jeff Brodsky. FASEB Endoplasmic Reticulum meeting, Melbourne, Florida.
@FASEBorg
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22 May 2025
Dan, a friend for many of us, passed at the end of last year. Before leaving, with his students and colleagues, he prepared this gift. Amazing. N-glycan-dependent protein maturation and quality control in the ER | Nature Reviews Molecular Cell Biology nature.com/articles/s41580-0…
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6 May 2025
Two structurally targeted allosteric regulators of GCase folding promote lysosomal transport of disease-causing variants, reduce ER stress and rescue lysosomal functions. Therapeutic potential for GD, PD, and Dementia with LB.
mdpi.com/3299382 #mdpiijms via @IJMS_MDPI
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5 May 2025
Uncovering ERLAD: the ER-to-Lysosome Associated Degradation of large, aggregated, disease-causing, nasty misfolded proteins that fail to enter proteasomal-driven ERAD pathways.
sciencedirect.com/science/ar…
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maurizio molinari retweeted
5 May 2025
We’re proud to share that the Alpha-1 Foundation has been named one of the 2025 Best Nonprofits to Work For by @NonProfitTimes ! This recognition reflects our ongoing commitment to fostering a mission-driven culture that values collaboration, innovation, and impact. Read more: alpha1.org/alpha-1-foundatio…
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maurizio molinari retweeted
20 Apr 2025
We wish you and your loved ones a happy and meaningful Easter. 💐
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maurizio molinari retweeted
19 Apr 2025
Alpha-1 doesn’t just affect the lungs, it can impact the liver, too. On #WorldLiverDay, we’re shining a light on Alpha-1 liver disease and the importance of early diagnosis and support. To learn more about Alpha-1 and the liver, visit: alpha1.org/liver-disease/ #Alpha1Awareness
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maurizio molinari retweeted
17 Apr 2025
For those new to scientific research, please remember that the only thing that matters is the REPRODUCIBILITY of your study, not the impact factor or journal name. Thank you.
16 Apr 2025
for those new to scientific research, plz remember that “nature” is most definitely not the same thing than “nature communications”
5x gap in impact factor - nature papers make careers, nat comms make blog posts
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25 Mar 2025
Look at the table if you wish to become a healthy old man/woman/….
It’s from today’s Nature Medicine by A.-J. Tessier et al. Optimal dietary patterns for healthy aging.
Hopefully somebody will soon publish conflicting results proving that desserts are not that bad, after all.
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