The Muir lab investigates the physiochemical basis of protein function in complex systems of biomedical interest.
Joined July 2021
- Tweets 143
- Following 181
- Followers 1,153
- Likes 207
38 Photos and videos
Pinned Tweet
Apr 28
Check out our latest efforts published in @ChemicalScience on characterizing and engineering the NrdJ-1 intein for protein biochemistry and chemical biology applications! Congrats to @XuanjiaYe, Josh, Christian, @thegoodnush and Juner! @PrincetonChem
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Apr 28
Check out our latest efforts published in @ChemicalScience on characterizing and engineering the NrdJ-1 intein for protein biochemistry and chemical biology applications! Congrats to @XuanjiaYe, Josh, Christian, @thegoodnush and Juner! @PrincetonChem
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Apr 28
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The Muir Lab retweeted
Mar 18
Interested in histone H3 serotonylation? Then check out our brand new preprint out today! This work was spearheaded by Instructor extraordinaire, Dr. Min Chen of the Maze Lab, and represents another great collaboration with the labs of Drs. Haitao Li, @MuirLab, David Li, Samuele
Quinone reductase 2 reads H3 serotonylation to support neuronal maturation biorxiv.org/content/10.64898… #biorxiv_molbio
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The Muir Lab retweeted
With a background in math and physics, Postdoc Jeremy Owen's the first-ever computational theorist hired into the @MuirLab. He investigates the “dizzying complexity” of chromatin.
Enjoy the first of our stories celebrating the postdocs of @PrincetonChem: bit.ly/4lgOmiy
ALT Full-color image of Postdoc Jeremy Owen standing on one of the interior bridges at Frick Lab. (Photo: Mahrad Saghafi)
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The Muir Lab retweeted
Jan 2
2/9. This work was a true teamwork. Huge congratulations to our collaborators at @kadochlab , @MuirLab , @GygiLab , Michael Gross (WashU). Special thanks to Kadoch lab members - @CKadoch, Dr. Kaylyn Williamson, @alex2110x, Aasha Turner, Maxwell Allison, Kevin So!
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The Muir Lab retweeted
Jan 2
1/9. Happy 2026, everyone! We are excited to share our new study on how mSWI/SNF chromatin remodeling complexes interact with DNA sequence-specific Transcription Factors (TFs), out this week in Science! @ScienceMagazine
Doi: doi.org/10.1126/science.aeb3…
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The Muir Lab retweeted
2 Oct 2025
Today, we introduce a nomenclature that can express discrete PTMs, proteoforms, nucleoforms, or situations where defined PTMs exist in an uncertain context and can describe how proteoforms are configured in functionally distinct complexes across biology. authors.elsevier.com/c/1lt5I…
ALT Today, we introduce a nomenclature that can express discrete PTMs, proteoforms, nucleoforms, or situations where defined PTMs exist in an uncertain context. Though specifically designed for the chromatin field, adaptions of the framework could be used to describe—and thus dissect—how proteoforms are configured in functionally distinct complexes across biology. Thank you to the many co-authors for your input and support. https://authors.elsevier.com/c/1lt5I3vVUPVb4c
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The Muir Lab retweeted
23 Sep 2025
Congratulations to our Tom Muir @MuirLab on being awarded the @AmerChemSociety's Ralph F. Hirschmann Award in Peptide Chemistry for exceptional achievement in the field. Well done, Tom!
Enjoy our story here: bit.ly/3KhNITt
ALT Full-color image of PI standing in his office, window in background.
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30 Aug 2025
With the start of the new academic year comes several farewells from our lab, as senior members of the lab graduate. First off, congratulations to our “transposein” Dr Yi Hua, who is heading off to @Stanford for a postdoc with @aliceyting
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30 Aug 2025
And last but not least, we have Dr Yingzi Huang, who presented a wonderful seminar on her chromatin within the context of DNA damage. Stay tuned for this story…
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The Muir Lab retweeted
20 Aug 2025
Congratulations @MuirLab postdoc Jason Johansen-Leete on his Life Sciences Research Foundation Fellowship, sponsored by Amgen, for his project: “High-resolution mapping of the BAF interactome with novel chemoproteomic technologies.”
Well done, Jason!
ALT Full-color head-and-shoulders image of Jason.
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19 Aug 2025
Congratulations to Tom for receiving the Ralph Hirschmann award in Peptide Chemistry! @PrincetonChem
cen.acs.org/people/awards/AC…
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Nature research paper: Programmable protein ligation on cell surfaces
go.nature.com/40HmcEs
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The Muir Lab retweeted
4 Aug 2025
The @MuirLab introduces a groundbreaking protein activation platform that allows “exquisite precision,” in @Nature last week.
Enjoy our story on this @NIH funded research by Christian, Girum, Nicholas, Xuanjia, Yutong and Tom:
bit.ly/3IThY6F
ALT First author Christian Kofoed, a former postedoc in the Muir Lab, standing outside with a flowering tree behind him.
ALT Head-and-shoulders full-color photo of grad student Girum Erkalo standing in Frick Lab.
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The Muir Lab retweeted
3 Aug 2025
Very happy to share this preview in @TrendsinBiotech two cool intein papers just out in @ScienceMagazine by @GMBurslem, @ophirshalem & @MuirLab. Beautifully written by my new postdoc, Kevin Schiefelbien🤩
@Penn @PrincetonChem
authors.elsevier.com/a/1lXcK…
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30 Jul 2025
What if protein function could be triggered only when the right cell cues are present? With SMART, we combine split inteins and logic gating to create a programmable system for cell-specific protein ligation, thus opening new doors for synthetic biology and cell targeting.
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30 Jul 2025
We anticipate that this technology will enable targeted formation of biomolecules with reduced off-target toxicity. This paper is the start of many applications for SMART and stay tuned for more!
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30 Jul 2025
Congratulations to Christian, Girum, Nick, Xuanjia, and Yutong!
Link: nature.com/articles/s41586-0…
@PrincetonChem @PrincetonInnov
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