A wonderful collaborative effort with Peter Walter @UCSF @stephenfloor @Lan_Wang_ @KroganLab @dlswaney led us to discover that Legionella toxin SidI possesses a tRNA-like shape and glycosylates the translation machinery to induce ribotoxic stress biorxiv.org/content/10.1101/…

The link for the faculty position is now posted! Deadline is October 15th. Please share widely with talented scientists in your network. Come join us at UCSF! aprecruit.ucsf.edu/JPF05243

A surprise gift of « new curve crease origami » we call Lacrygami brought to us by a single cell (this is the first example of origami in a single cell)!! Will write a longer thread shortly describing our journey to discovery - in mean time, enjoy this beautiful cell.

We are excited to report our latest finding that Legionella creates a unique niche that is independent of the host ER network.

#FluorescenceFriday #cellbiology #bioart The interior of the cell is a busy place, as seen by grazing incidence structured illumination microscopy at 30 frames per minute: Lysosomes (green) can become corralled by the endoplasmic reticulum (ER, magenta), but can also remodel the ER when they are actively transported at high speed along microtubules (MTs, yellow). ER tubules are also remodeled directly when they associate with the growing or shrinking ends of MTs. doi.org/10.1016/j.cell.2018.…

NEW MBoC Call for Papers: Special Issue on Cell Biology of Infection! Submit an article by Oct 30 to be considered by lead editors: Nihal Altan-Bonnet, @nih_nhlbi @Mukherjee_Lab, @UCSF Learn more and submit: molbiolcell.org/cell-biology…

Exciting update! Starting December 2, 2023, all ASCB member submissions to MBoC are ensured a thorough peer review. Simply ensure the corresponding author is an ASCB member to qualify.

🎁Interested in reading more about the study? Here is the N&Vs article written by Shu-Bing Qian and Saori Uematsu: rdcu.be/dp6jU nature.com/articles/s41556-0…

Thank you @NatureCellBio for accepting this work! We are absolutely thrilled!

Excited to announce that the Department of Microbiology and Immunology @UCSF is seeking candidates for a tenure-track faculty position at the Assistant Professor level. aprecruit.ucsf.edu/JPF04655 Please RT.

We are delighted to announce our #ISFS2023 Fellows. Congratulations and welcome to ISFS! We will be highlighting them all through August! To learn more about our fellows visit: intersectionssciencefellows.…

Tenure-track faculty search of the @Ucsf_Biochem Department is open for applications! We are looking for creative, innovative scientists asking fundamental questions in any area of biology. Join our vibrant, collaborative, and supportive community! aprecruit.ucsf.edu/JPF04637

Bacteria can counter noncanonical lipid ubiquitination with a #ubiquitin esterase! Fantastic collaboration with @ThurstonLab and @CMBI_Szczesna, with @r_lacoursiere driving our side of the project using some amazing tools built by the Geurink lab.

Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in @Nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. nature.com/articles/s41586-0…

I am happy to propose a model for mammalian #mitochondria UPR signaling, published @Nature. nature.com/articles/s41586-0… Mito protein misfolding induces two cytosolic signals –mtROS and mito protein precursor accumulation. These activate the mito UPR via a DNAJA1-HSF1 signaling axis.

Congratulations to the talented scientists joining our community of Pew scholars and fellows. We are so happy to have you!!!

Pleased to describe our latest contribution to the #Legionella world, as we define a clear role for unique phosphoribosyl-ubiquitin transferases in protecting the Legionella-containing vacuole from host driven disintegration. biorxiv.org/content/10.1101/…

🚨We're back! Applications for the next #ISFS23 are now open! Postdocs interested in faculty careers: Apply to showcase your work, network w/ hiring institutions, receive mentorship, and connect w scientists from diverse backgrounds! Pls share broadly! intersectionssciencefellows.…

So well-deserved! Congrats, Kevan!!!

Passionate about both research and #DEI? Applications just opened for this tenure track faculty search across @UCSF basic science departments, in all areas of fundamental biomedical research. Join our vibrant, collaborative, supportive community! aprecruit.ucsf.edu/JPF04050

Tenure-track faculty search of the @Ucsf_Biochem Department is open for applications! We are looking for creative, innovative scientists asking fundamental questions in any area of biology. Join our vibrant, collaborative, and supportive community! aprecruit.ucsf.edu/JPF04089