Joined March 2018
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29 Oct 2023
Today on #WorldPsoriasisDay, please check out our manuscript that is just out in @NatureGenet about somatic evolution in the skin of psoriasis patients
nature.com/articles/s41588-0…
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Sigurgeir Olafsson retweeted
30 Nov 2023
UK biobank WGS 500k data available
science.org/content/article/…
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6 Nov 2023
Check out this work by my @decodegenetics colleagues, Simon Stacey and Florian Zink, on clonal hematopoiesis that appeared in @NatureGenet today:
nature.com/articles/s41588-0…
They show that you can call CH based on a mutation "barcode" in the absence of a typical driver mutation.
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6 Nov 2023
Very importantly, this large-scale study of two biobank scale cohorts failed to find evidence that clonal hematopoiesis causes heart disease. It suggests that the associations previously reported are the result of confounding between smoking behaviour and these phenotypes.
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6 Nov 2023
Germline variants at 25 loci influenced the risk of developing CH. These do not show association with cardiovascular disease and Mendelian Randomization further gave no indication that they increase the risk of cardiovascular disease.
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29 Oct 2023
Today on #WorldPsoriasisDay, please check out our manuscript that is just out in @NatureGenet about somatic evolution in the skin of psoriasis patients
nature.com/articles/s41588-0…
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29 Oct 2023
The signature also shows a very strong transcription strand bias. This is driven partly by transcription coupled repair but also by transcription-coupled damage, similar to what has been described for SBS16 in the liver.
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29 Oct 2023
Many thanks to all the co-authors. @anderson_carl, @andrewrjlawson, @Axel_R_Huber, @imartincorena and others not on twitter. It was a pleasure working with you on this project.
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Sigurgeir Olafsson retweeted
27 Jan 2023
Check out this great piece of work describing somatic mutations in the normal small intestine. The cancer incidence of the small bowel is an order of magnitude lower than in the large intestine and yet the somatic mutation rate is the same. Must be explained by diff selection (?)
26 Jan 2023
Our latest work about the landscape of somatic mutations in human small intestine epithelium and APOBEC mutagenesis is online @NatureGenet and it’s open access!
go.nature.com/3j4li2e
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13 Oct 2022
What a great lineup of speaker for #NSHGPM2022! I will present our meta-analysis of somatic substitutions and indels in several thousand colorectal cancers. First time @decodegenetics does large scale sequencing of a tumour cohort, but I don't think it will be the last
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10 Oct 2022
You need to do 455 colonoscopies to prevent one case of colon cancer. Seems like a lot. It would be interesting to see how polygenic risk score stratification would improve those numbers.
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