In #HeartMonth and on #WearRedDay I am pleased to announce a new PhD studentship in my lab to study and develop novel therapies to target cardiovascular disease development, application deadline March 6 for a October 2026 start, please RX:
eur03.safelinks.protection.o…
✨ Thrilled to share our new publication in Nature.
We define an “inflammatory memory” HSC state (HSC‑iM), linking lifelong inflammatory exposure to aging and disease.
📄 Article: nature.com/articles/s41586-0…
Grateful to an incredible team and global collaborators 💚💙
The ramp up of cancer immunotherapy is remarkable. Now we're seeing vaccines achieve some cures or remissions in the most refractory cancers: pancreatic, melanoma, glioblastoma, renal, triple-negative breast cancer.
✓ out the new Ground Truths (link in profile)
Review series on clonal hematopoiesis: the driver mutations.
This review explores how driver mutations shape stem cell fitness and how inflammatory progeny may promote clonal advantage and disease risk.
haematologica.org/article/vi…
We published a new preprint on BioRxiv. We uncovered a pyroptosis-driven stromal-immune circuit that explains why TET2 mutations progress to myeloid disease, and how to disrupt it. This work is led by @Kehan_Ren_PhD. bit.ly/42pjgwB
Review series on clonal hematopoiesis: from CHIP to myeloid neoplasms.
What drives progression from clonal hematopoiesis to myeloid malignancy? This review explores risk, biology, and emerging therapeutic strategies.
haematologica.org/article/vi…
#AML world awareness day. AML symptoms can be mistaken with several other diseases but a simple blood test can give an early diagnosis and access to treatment. Sign up to @AnthonyNolan or @DKMS_uk to become a potential stem cell donor and save a life.
Ian saw his GP twice but wasn’t taken seriously. He was eventually diagnosed with acute myeloid leukaemia (AML) at A&E.
Like Ian, 1 in 4 people with leukaemia face delays in diagnosis.
Add your name to end the delays: action.leukaemiauk.org.uk/en…#AMLWorldAwarenessDay#CountUsIn
With Razan Aljohani at #BSH2026 Young EHA who is presenting her data on the role of Zeb1 in AML. Razan is coming to the end of her PhD at @ECSCRI and is showcasing data as part of her contribution to @bloodcancer_uk funded project led by @NRodriguesLab. 👏 Razan on your poster
Excited to be #BSH2026 in Liverpool. Attending Young EHA. @EllieMcCracken1 👏 has been selected to deliver an oral presentation on fusion gene roles in erythroid development funded by Myristica Trust @haematology_CU@MEDICPGR. Attending with Jess Mundy, aspiring researcher
Beautiful editorial highlighting Dr. T. Ray Bradley’s pivotal role in @ISEHSociety and Exp hematology. Thanks to @purton_louise, Susie, Ivan, Richard, and Toshio for early-HSC insights and Ray’s agar colony-forming cell assay, revealing BM progenitors.
exphem.org/article/S0301-472…
❓A one-time, durable, and even reversible way to prevent thrombosis? In this preprint, led by @lrbzldz, we show that epigenome editing of 🩸 #StemCells can durably reprogram platelet function: biorxiv.org/content/10.64898…
First (to my knowledge) manuscript describing a correlation between number of infections and incidence of clonal hematopoiesis (CHIP). Really important from the perspective of highlighting a possible modifiable driver of CHIP during aging. @ISEHSocietyexphem.org/article/S0301-472…
In #HeartMonth and on #WearRedDay I am pleased to announce a new PhD studentship in my lab to study and develop novel therapies to target cardiovascular disease development, application deadline March 6 for a October 2026 start, please RX:
eur03.safelinks.protection.o…
New post: Research Fellow in Biochemistry & Biomedicine (Fixed Term)
Ref: 43139
Closing Date: 08 March 2026
To apply visit: jobs.sussex.ac.uk/job/4fee4e…
We show that some individuals are protected from blood cancers because their blood stem cells operate with lower MSI2 activity. This provides human genetic evidence supporting inhibition of MSI2 or its downstream targets for blood cancer prevention. (3/n)
What protects individuals from developing blood cancers?
Thrilled to share my work in @bloodgenes lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇(1/n)
biorxiv.org/content/10.1101/…