UCSD AHFTC Fellow 2025-26 | UC Davis Cardiology '25 | UCLA Internal Medicine '22 | Tulane MD/MBA '19 | Believer in Heart Success |
Joined October 2020
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14 Nov 2022
A ๐งตon STRONG-HF ๐ช๐พ๐ซ
โญ๏ธThe first randomized trial to show the immense benefits of a comprehensive high-intensity med-titration program with #HF GDMT
โHow did the investigators achieve an 8.1% ARR in HFH/mortality at 6 monthsโ
Letโs see what we can learn ๐๐พ๐งต
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Neal Dixit, MD retweeted
May 22
Wonโt ๐ cost too much?
With generic pricing: $3.5 billion a year
Optimal implementation in eligible patients with HF, CKD & T2DM is projected to:
๐ฅ Reduce billions in CV/HF ๐จs
๐ซ Avoid dialysis costs in CKD
Not prescribing SGLT2i way more costly
#SGLT2i #ValueBasedCare
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Mar 30
Excited to share our review on predicting sudden cardiac death in HFrEF led by outstanding med student Norayr Mkrtchyan!
It's a comprehensive look at the risk factors associated with sudden death in this population
@AntoinetteBirs @AHajduczok
link.springer.com/article/10โฆ
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Neal Dixit, MD retweeted
15 Apr 2025
Is finerenone ready for primetime in heart failure? We argue that the data suggest not yet. @NealDixit @cardiologyUc #AHAJournals ahajrnls.org/3Gn7QkZ
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Neal Dixit, MD retweeted
6 Dec 2024
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5 Dec 2024
Is it primetime for finerenone in HF?
Would love to hear why or why not?
Here is our perspective ๐๐พ
ahajournals.org/doi/10.1161/โฆ
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Neal Dixit, MD retweeted
4 Dec 2024
Congrats @NealDixit !!! Canโt wait for you to join the awesome team at @UCSDCardiology โค๏ธ
4 Dec 2024
Ecstatic to share that I will be joining @HowieTranMD and the team at @UCSDCardFellows for Advanced Heart Failure and Transplant Cardiology Fellowship!
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4 Dec 2024
Ecstatic to share that I will be joining @HowieTranMD and the team at @UCSDCardFellows for Advanced Heart Failure and Transplant Cardiology Fellowship!
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Neal Dixit, MD retweeted
2 Dec 2024
Is Finerenone just an expensive spironolactone?
"A RCT of nonsteroidal versus steroidal MRAs is desperately needed in the HF population"
Thanks for your thoughtful Editorial, @NealDixit and Saul Schaefer!
@dgfn_ev @YoungDgk @MarcusSaemann @hswapnil
ahajournals.org/doi/10.1161/โฆ
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Neal Dixit, MD retweeted
18 Sep 2024
Costs? Intolerance? Inertia? Other? Primary reason for gaps in #GDMTworks endlessly debated.
๐คWhat if we had US physicians audit their own patient charts & report *WHY* they didnโt prescribe #GDMT for #HFrEF in each case?
๐จ Results in @JACCJournals
jacc.org/doi/epdf/10.1016/j.โฆ
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22 Aug 2024
Will DANCAVAS be the most important screening trial in the last 50 years?
Interested to hear opinions!
Read our commentary ๐๐พ
sciencedirect.com/science/arโฆ
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Neal Dixit, MD retweeted
16 Jul 2024
Cost-Effectiveness of GDMT for HFmrEF & HFpEF
jacc.org/doi/10.1016/j.jchf.โฆ
@JACCJournals #JACCHF @gcfmd @boback @mvaduganathan @NealDixit @katieptr
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Neal Dixit, MD retweeted
3 Jul 2024
In #JACCHF @JACCJournals: cost effectiveness of medical tx for #HFmrEF & #HFpEF
*At current cost, MRA high value, SGLT2i intermediate value, & ARNI low value
*If generic, all are high value
๐Need equitable access to meds for all!๐
jacc.org/doi/10.1016/j.jchf.โฆ
@gcfmd @NealDixit
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Neal Dixit, MD retweeted
1 Jul 2024
Generic priced options are here or just around the corner
Cost-Effectiveness of Medical Therapy for Heart Failure With Mildly Reduced and Preserved Ejection Fraction | JACC: Heart Failure jacc.org/doi/10.1016/j.jchf.โฆ
@NealDixit @JACCJournals
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Neal Dixit, MD retweeted
16 May 2024
Should you wake up the patient when you preround?
Not only is there a #kittlesonrules for that, there's also a piece in this week's NEJM. Check it out :)
nejm.org/doi/full/10.1056/NEโฆ
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Neal Dixit, MD retweeted
Once again, nice work @NealDixit . I often start SGLT2- and MRA first as easy to get to targeted dose fast. Now its cost effective too!
13 May 2024
What is a cost-effective GDMT strategy for HFmrEF/HFpEF?
We built a model w/ clinical trial data (TOPCAT, PARAGON-HF, EMPEROR/DELIVER) and simulated outcomes w/ regimens of MRA/SGLT2i/ARNi.
Best ๐ combo?
MRA SGLT2i
ARNi โฌ๏ธ value at current ๐ต
Treat HF with urgency!
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13 May 2024
What is a cost-effective GDMT strategy for HFmrEF/HFpEF?
We built a model w/ clinical trial data (TOPCAT, PARAGON-HF, EMPEROR/DELIVER) and simulated outcomes w/ regimens of MRA/SGLT2i/ARNi.
Best ๐ combo?
MRA SGLT2i
ARNi โฌ๏ธ value at current ๐ต
Treat HF with urgency!
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13 May 2024
Many thanks to the team of @gcfmd @katieptr @boback @mvaduganathan
Read the full article here:
jacc.org/doi/10.1016/j.jchf.โฆ
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Neal Dixit, MD retweeted
4 May 2024
๐ถ๐ต Cost-Effectiveness of Medical Therapy for HFmrEF/HFpEF
๐MRA
๐๐MRA SGLT2i
๐๐๐ MRA SGLT2i ARNI
โ๏ธ in life years of HFmrEF/HFpEF๐ฅ
๐1.04/0.99
2๏ธโฃ๐1.58/1.54
3๏ธโฃ๐1.80/1.77
๐MRA therapy ICERs of $10,000 per r
QALY in both subgroups
๐๐ICER $113,000 per QALY in the
HFmrEF subgroup and $141,000 in the HFpEF subgroup.
๐๐๐ICERs>$250,000 per QALY in both subgroups.
๐ก๐ฅ with HFmrEF/HFpEF โ๏ธ use of MRA and SGLT2i therapies should be encouraged
Via @JACCJournals @mvaduganathan @gcfmd @NealDixit &cia
๐ jacc.org/doi/10.1016/j.jchf.โฆ
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Neal Dixit, MD retweeted
1 May 2024
Cost effectiveness analysis of ๐ Rx in HFmrEF/HFpEF
Timing of generic pricing is ๐
Cost-Effectiveness of Medical Therapy for Heartย Failure With Mildly Re... sciencedirect.com/science/arโฆ
@boback @NealDixit @JACCJournals
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Neal Dixit, MD retweeted
26 Apr 2024
Really good point by Gary Mintz re PREVENT trial- does it make sense to do 803PCIs to prevent 12 cardiac events, of which only 5 were cardiac death / tv-mi #TCTAP2024 @summitmd_cvrf @dukwoo_park @Hragy @thiele_holger @ziadalinyc @djc795 @SukhNijjer @KardiologieHH @DFCapodanno @SwissHeartDoc @NishithChandra
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