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Martin_Oheim @OheimMartin

Physicist by training, biophysicist by passion. Founding and Managing Director of the Paris based CNRS Saint Pères Paris Institute for the Neurosciences (SPPIN)

Joined May 2018
  • Tweets 36
  • Following 36
  • Followers 66
4 Photos and videos
We are proud to announce that our work "Label-free, high-resolution fluorescence imaging of the intestinal wall by image scanning and confocal microscopy by Marwa Moulzir*,  Doriane Hazart,* Clément Ricard✉ and me is out in Gastro Hep Adv ! Congratulations to Marwa and Doriane.
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This is the first chapter of our large work tansforming Fourier-plane imaging from an expert-dependent technique into a reproducible and scalable tool for surface-sensitive fluorescence microscopy for routine super-resolution biological imaging.
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I am thrilled to announce a new pre-print: arxiv.org/abs/2505.13190 : "Combinatorial Sample-and Back-Focal-Plane (BFP) Imaging. Pt. I: Instrument and acquisition parameters affecting BFP images and their analysis". Check it out!

Combinatorial Sample-and Back-Focal-Plane (BFP) Imaging. Pt. I:...

The back-focal plane (BFP) of a high-numerical aperture objective contains the fluoro-phore radiation pattern, which encodes information about the axial fluorophore position, molecular orientation...

arxiv.org
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UbiClear: a new ultra-fast and natural biological tissue clearing process erganeo.com/en/licence_Idyll…
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The SPPIN is an recruiting an optical engineer for boosting its core unit, 1-year prospect of a science of job: emploi.cnrs.fr/Offres/CDD/UM…
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📢 Exciting new product alert with the launch of CNRS-SPPIN's UbiClear! Our new, universal, non-toxic and ultra-fast clearing is out! available at idylle-labs.com/shop/ubiclea…, UbiClear is the solution. 🔬 #Innovation #Biotech #Research
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I am very happy to share Antonin SINGER's first publication, now available as a pre-print on bioRxiv. Antonin and co-workers have revisited an enigmatic cerebellar glial cell that has long been forgotten: the feathered cell of Fañanas. Check it out: biorxiv.org/cgi/content/shor…
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And a nice example of the problems of scientific publishing: our bioRxiv (doi: doi.org/10.1101/2022.06.15.4…) has been around since June, the (not so different) final paper is out only now, and this despite a smooth and efficient review process...
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An alternative to conventional H&E staining and histology, for neuroanatomists, but also for clinicians. It's fast, it's powerful and easy. Label-free, fast, 2-photon volume imaging of the organization of neurons and glia in the enteric nervous system frontiersin.org/articles/10.…

Frontiers | Label-free, fast, 2-photon volume imaging of the organization of neurons and glia in...

The enteric nervous system (ENS), sometimes considered as a ‘second brain’ due to its large autonomy from central circuits, is made up of interconnected plex...

frontiersin.org
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Just a nm-step at the sample, but a leap ahead for quantitative surface microscopies... Characterizing nanometric thin films with far-field light biorxiv.org/content/10.1101/… Check out our new work by Hodaya Klimovsky et al,. now out as a preprint. Big thanks to all co-workers!

Characterizing nanometric thin films with far-field light

Ultra-thin, transparent films are being used as protective layers on semiconductors, solar cells, as well as for nano-composite materials and optical coatings. Nano-sensors, photonic devices and...

biorxiv.org
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We did it. Coming soon on arXiv. Stay tuned.
It's new. It's cool. And it is out now. Check out our first work on the enteric system, the second brain in the gut Label-free, fast, 2-photon volume imaging of the structural organization of peripheral neurons and glia in the enteric ganglia biorxiv.org/content/10.1101/…

Label-free, fast, 2-photon volume imaging of the structural organization of peripheral neurons and...

The enteric nervous system (ENS), sometimes considered as a ‘second brain’ due to its large autonomy from central circuits is made of interconnected plexuses organized in a mesh-like network lining...

biorxiv.org
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Our new light sheet is starting to get form. Big thanks to Frédéric Brau (Valbonne) and Thierry Bastien (Paris).
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A surprisingly simple, inexpensive and multi-scale test sample for 3-D imaging: check it out, to appear shortly in Wiley's MRT. Here is the preprint: biorxiv.org/content/10.1101/…

A simple, inexpensive and multi-scale 3-D fluorescent test sample for optical sectioning microsco...

Fluorescence standards allow for quality control and for the comparison of data sets across instruments and laboratories in applications of quantitative fluorescence. For example, users of microscopy...

biorxiv.org
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Martin_Oheim retweeted
Society of General Physiologists
@sgpweb
26 Feb 2021
The young #investigator Cranefield #award🏅 goes to Federico Trigo, then at @Univ_Paris, now at @IIBCE👏🏽. Trigo and colleagues used cutting-edge biophysical techniques to show that the prior history of Ca2 elevation affects release probability of vesicles that fuse…
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Fresh from the press and finally out in the Biophysical Journal: Pulse-length effects in 2P-micoscopy. I. Infrared excitation induces brain heating and calcium microdomain hyperactivity in cortical astrocytes£ cell.com/biophysj/fulltext/S…
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SPPIN's Bruno Gasnier lab together with Francine Acher's group published in J Med Chem : Dubois et al. (2020) Amino acids bearing aromatic or heteroaromatic substituents as a new class of ligands for the lysosomal sialic acid transporter sialin (SLC17A5). Congratulations !!
Our new work on SAF is out in the Biophysical J: Journal doi.org/10.1016/j.bpj.2020.0…
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Mahesh Karnani's impressive new work is out: Check out this truly original piece of work. Happy to have you soon as a group leader with SPPIN. Congratulations, MO Ultra-sparse connectivity within the lateral hypothalamus biorxiv.org/content/10.1101/…

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Along the lines of our recent Biophys. J. (authors.elsevier.com/a/1ZgGf…) we are 𝗵𝗶𝗿𝗶𝗻𝗴 a postdoc fellow interested in contributing to metrology and standardisation in biological super-resolution microscopy. Please RT and contact if interested martin.oheim@parisdescartes.fr
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