Two other Reviews in the October issue highlight #E3ligases in 1) #ProteinQualityControl degradation and 2) how mutations of them and other ubiquitin machinery impact #neurodevelopment and #neurodegeneration (@ColinZenge @Ordureau_Lab).

Postdoctoral Fellow in Cell Biology, Biochemistry or Proteomics (New York). Come join us as a Postdoctoral Fellow to study #Ubiquitin, #Autophagy, #Biochemistry, and #Proteomics at the Sloan Kettering Institute in New York. jobrxiv.org/job/sloan-ketter… #... jobrxiv.org/job/sloan-ketter…

The picky mTORC1 in metabolic enzyme degradation dlvr.it/T84khr

We’re excited to share our study in @CellCellPress on the role of the MAP3 kinase ZAK in UV-induced apoptosis led by @2primehydroxyl! We studied cell signaling kinetics following UV-damage and found that ZAK drives apoptosis via ribosome collisions. cell.com/cell/fulltext/S0092…

Very happy to see this study conducted with @GreenLabJHMI, @RegotLab @CantleyLab labs, published. Massive opus from Niladri (@2primehydroxyl), revealing the ribotoxic stress response drives UV-induced apoptosis. Congrats to Niladri and everyone involved! cell.com/cell/fulltext/S0092…

Check out the study on the first identified human protein whose stability is regulated via Pro/N-degron and CTLH E3 ligase

Fun collaboration with the @AnLab_MSKCC - #Ubiquitin #mTOR #Metabolism