This chart is a great example of how you can make 300,000 people disappear with a bad question.
Let’s be very clear—because you deserved that clarity at 52 after a heart attack:
1) The wrong endpoint is doing all the work
They’re plotting LDL reduction vs all-cause mortality across trials.
That sounds reasonable—until you realize:
Most statin trials were not powered for all-cause mortality
Many include low-risk or mixed populations
Follow-up is often too short to show mortality differences
So the “flat line” is not surprising. It’s expected.
2) This ignores the outcome that actually matters in these trials
Statins were never primarily about “living forever.”
They reduce:
Recurrent heart attacks
Strokes
Cardiovascular death (in higher-risk groups)
If you collapse everything into “all-cause mortality,” you dilute the signal with:
cancer deaths
accidents
unrelated disease
That’s not honesty—that’s statistical camouflage.
3) Secondary prevention (you) is a completely different universe
You had a heart attack.
That puts you in secondary prevention, where the data are not subtle:
Statins reduce major vascular events ~20–25% per mmol/L LDL drop
Clear reductions in recurrent MI and stroke
Mortality benefit shows up more consistently in higher-risk patients
This isn’t fringe—that’s decades of consistent evidence.
4) Mixing drugs = muddy conclusions
They lump together:
statins
PCSK9 inhibitors
ezetimibe
Different mechanisms, different trial designs, different populations.
That’s like averaging antibiotics, chemotherapy, and aspirin and concluding “medicine doesn’t work.”
5) The visual trick
The graph implies:
“If LDL mattered, the dots would go up.”
No.
That assumes:
identical populations
identical baseline risks
identical durations
None of which are true.
It’s a correlation plot across heterogeneous trials, not a causal test.
My doctor put me on a statin after my heart attack at 52.
I trusted him. I took the pill. I never asked a question.
Then I found this study. 60 clinical trials. 323,950 people. Every cholesterol lowering drug ever made. Statins. PCSK9 inhibitors. Ezetimibe.
They measured how much each drug lowered LDL cholesterol. Then they measured whether people lived or died.
The line is flat.
It did not matter if they lowered LDL by 10% or by 70%. The death rate did not change. In some trials people died more.
323,950 people. Near zero benefit. Published in the Journal of Cardiovascular Pharmacology. 2023.
Nobody showed me this chart. Not my cardiologist. Not my pharmacist. Not the drug rep who visited my doctors office every month.
I had to find it myself. After the heart attack.