👏 Huge collaborative effort
Led by Drs. Fran Balamuth & Scott Weiss (Co-PIs) w/ Dr. Nate Kuppermann as senior author
This study highlights the power of international research networks — essential for trials of this scale & impact
@PECARNteam@PERC_Network@PREDICT_Network@nkuppermann@FranBalamuth
💡 Bottom line:
•These findings demonstrate that BOTH fluid options are appropriate for treating suspected septic shock
•This is applicable across diverse clinical settings
•Clinicians should focus on timely recognition & fluid resuscitation with available crystalloid
@nkuppermann@franbalamuth
…both!
PRoMPT BOLUS found:
• 0.9% saline AND balanced fluids are safe & effective in suspected pediatric septic shock
• Fluid type does NOT impact major outcomes (mortality, kidney injury)
• Biochemical differences ≠ differences in patient-centered outcomes
@PERC_network@PREDICT_networknejm.org/doi/full/10.1056/NE…
🚨 Hot off the press! 🚨
Introducing the PRoMPT BOLUS study results — a landmark trial evaluating the safety & efficacy of normal saline vs. balanced fluids in suspected pediatric septic shock
🌍 9,000 children
🏥 47 sites
🌎 5 countries
And the winner is… 👇
nejm.org/doi/full/10.1056/NE…@nkuppermann@franbalamuth
PRoMPT BOLUS results are coming!!!
Led by Drs. Balamuth, Weiss & Kuppermann, this international study evaluated NS vs. balanced fluids in the treatment of pediatric #sepsis
Results come out on Friday, April 25 at @PASMeeting
but check out everyone's guesses below...
This trial was made possible through collaboration w/ @PECARNteam@PERC_Network and @PREDICT_network@nkuppermann@FranBalamuth
Attending PAS? Attend this session to be the first to hear results from our multi-network PRoMPT BOLUS study on optimal fluid choice for initial resuscitation in pediatric sepsis! @PECARNteam@PREDICT_network
Fantastic panel session with experienced @PREDICT_network research nurses telling us all the secrets to study enrolment in the ED!
Lots of “pearls” Darwin, Auckland, Perth and Adelaide…
Great chairing by @LibbyHaskell
Alfred Liu presenting his findings on management of pain and distress associated with nasogastric tube insertion in young children
A nice collaboration between @circan_network and @PREDICT_network
Over 1200 responses to the survey!
~BREAKING NEWS~
PEAChY-O is finished > 348 participants
Thanks to: Prof Franz Babl (CPI), @DrSimonCraig (grant CIA), Kate Klein (trial coordinator), the PIs, RAs, ED clinicians & the participants.
Stay tuned for results!
@PREDICT_network
(Photo of my little 🍑 for the algorithm)
A huge thank you to @SEMI_India for hosting a @PREDICT_network PEM research workshop today at #EMCON2023
Some excellent ideas for new projects and lots of potential for collaboration.
We very much look forward to working together in the future!
Thank you to all the incredible RAs and PIs who attended our training day for 5 new @PREDICT_network studies!
Looking forward to improving care for children and young people across a wide range of conditions.