Ophthalmic Oncopathologist & Head of Laboratory Services @ Sankara Eye Foundation | Image Analysis Enthusiast | Collaborative & Translational Research

Joined October 2013
96 Photos and videos
Dr. Rishikesh Balvalli retweeted
29 Apr 2024
So how do we decide which child needs to be on the ( government) list for receiving a heart transplant? ✅ The child must have heart failure that is no longer responsive to medicine and there is a very high chance that the child will not survive for more than a year. ✅ Our best efforts have shown that the heart failure in the child is not due to a treatable cause. And heart transplant is the only way out. ✅ The child passes a head to toe check up ( blood tests and imaging tests) to make sure the other organs of the child can provide the sustenance that the new heart will need in order for the child to have a better life ahead. ✅ Very imp: the family of the child is counselled about their life after their child receives a heart transplant. ... the mental, social, financial implications.. A formal psychology consultation is done for the family. Here is a documentry by @NatGeoIndia on one such child ( India's incredible rescue ops series) . We happened to be the team the family chose to go down the path of heart transplant . hotstar.com/1260120539

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Dr. Rishikesh Balvalli retweeted
Deeply shocking to read this official US statement, which contains absolutely no expression of regret or condolence for the loss of innocent Indian lives. How can a “friend” and strategic partner be so deeply insensitive? Why couldn’t a non-compliant commercial vessel have been stopped using other, non-lethal means? Is it not possible to disable a ship's propulsion or steering without firing missiles targeted to kill civilian crew members? Practically every merchant ship navigating these crucial waters has Indian crew on board. Are they all considered fair game for US missiles now? This approach is unacceptable and I hope @DrSJaishankar had said so to @marcorubio.
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Dr. Rishikesh Balvalli retweeted
Sir, they have blocked access to the very AI models you said we should share instead of build
India doesn't need to lead the world in building the most advanced AI models. But it must lead in ensuring benefits of AI are widely shared. @rvenk and I have an op-ed in The @EconomicTimes economictimes.indiatimes.com…
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Dr. Rishikesh Balvalli retweeted
Jun 12
All of these were reported over the past month: • A new pancreatic cancer drug, daraxonrasib, that roughly doubles survival in late-stage disease • A precision lung cancer drug, lorlatinib, that kept 55 percent of patients progression-free after 7 years, versus 3 percent on the old drug • A prostate cancer drug, talazoparib, that halves the risk of progression • An endometrial cancer drug, dostarlimab, where 58 percent of patients hadn't progressed after 4 years, versus 16 percent on chemo alone • An early-detection blood test, the NHS Galleri test, that quadrupled cancer detection but missed its main goal • An mRNA cancer vaccine that halved the risk of melanoma recurrence when added to Keytruda • The most effective weight loss drug so far, retatrutide, which cut body weight by about 28 percent • The first in vivo gene editing therapy, which cut hereditary angioedema attacks by 87 percent from a single injection • A one-time gene edit, VERVE-102, that lowered LDL cholesterol by 62 percent • A feat of pharmaceutical synthesis that raised enlicitide's manufacturing yield 14-fold using engineered enzymes • A functional cure for hepatitis B, bepirovirsen, that cleared the virus in about 20 percent of patients • The discovery that human cells can swap chromosome-sized DNA through nanotubes • An ancestor of CRISPR, VIPR, found in bacteriophages, that silences genes without cutting DNA • A preventive Covid-19 pill, ensitrelvir, that cut symptom risk by 67 percent after exposure • The first PROTAC drug, vepdegestrant, which destroys a disease-causing protein rather than blocking it Every month, Niko and I write a round up digging into the latest news in biotech and medicine, and this month's was astonishing. We share some thoughts on what's responsible for this progress and what it means for science in the future.
Jun 12
New post! @NikoMcCarty and I have been writing regular round ups for a little while now, but so much has happened recently that this month’s What's New in Biology post feels like it contains a year’s worth of breakthroughs. worksinprogress.news/p/whats… The most effective weight-loss drug so far, cancer breakthroughs, gene editing for cholesterol, ancestral CRISPR systems, a cure for some with hepatitis B, the first PROTAC drug, and more. Read it here!
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Dr. Rishikesh Balvalli retweeted
Good morning everyone, Since the day we appeared for the NEET-SS examination, our struggle has not ended. We worked tirelessly for this opportunity. The exam was one of the toughest in recent years, and every qualified candidate earned their seat through hard work, dedication, and merit. For more than a year, we balanced demanding hospital duties with exam preparation. We worked day and night, often sacrificing sleep, family time, and personal well-being. After the examination in December, we patiently waited for the results, which were declared in January. When the first round of counselling was completed, we hoped the process would move forward smoothly. Unfortunately, the uncertainty continues. Every day begins with hope that counselling will resume, and every day ends with disappointment. Even after the court proceedings were disposed of, we believed our wait was finally over. Yet we remain stuck in the same cycle of delays and uncertainty. I am 29 years old, and six precious months of my career have already been lost. This is not just an academic delay—it is a financial, professional, and emotional setback for thousands of aspiring super-specialists across the country. We respectfully request the authorities to consider our situation. We are not asking for any special favour. We are only asking for the opportunity we have rightfully earned through merit. We chose this demanding path because we want to serve patients and contribute to society. Please allow us to begin our training and continue our journey as healthcare professionals. Kindly do not let the future of thousands of doctors remain uncertain. Every day of delay adds to our academic and financial loss. We urge the concerned authorities to resume and complete the NEET-SS counselling process at the earliest. #ResumeNEETSSCounselling#NEETSS2025#DoctorsAwaitJustice#MeritMustPrevail @NMC_IND @NMC_IMA_IND @bhatia_nachiket @JPNadda @PMOIndia @MoHFW_INDIA @Minister_Edu @CMOTamilnadu @RahulGandhi @Dev_Fadnavis
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I still distinctly remember the quote outside our dissection hall. "Let conversation cease. Let laughter flee. This is the place where death delights to help the living" What have we come to.
As the controversy escalated, Dr. Sejal Pawar has made her Instagram account private. Here is the full story - On Pranit More’s stand-up show, Sejal jokingly revealed how she and her friends sometimes checked the size of male cadavers' private parts and made fun of them. If a male doctor had cracked a joke like that it, would have turned into a huge scandal; he would lost his job, and his licence would have been at risk. What is your opinion on this ?
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There are therapies to slow down the progression of myopia. A Pediatric Opthalmologist is the best subspecialist for it, especially in a dedicated tertiary care hospital with vision therapy facilities. You can consult @DrDivca at @SankaraV2020 if in Banglore.
Dear parents Go to an ophthalmologist if your child's number is increasing very frequently. DONT just go to the neighborhood spectacle shop. They will simply check the number and give your child new glasses. Nope. The correct way is to dilate the pupils (the pupils of the pupils hahahaha) and then get the number. The ophthalmologist will do this. This will , to a large extent, unveil ACCOMODATIVE SPASM of the eye muscles ( due to continuous strain due to excessive screen use) . Then the doctor will share ways to get rid of ACCOMODATIVE SPASM, excessive dryness of eyes and treat any allergic component. It may well turn out that your child did NOT need the new, stronger glasses. Ahem , the child may even be an 18 yr old. VISIT THE CORRECT SPECIALIST DOCTOR for your ailments . Another eg: for a child with heart concerns, go to a pediatric Cardiologist.
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Don't share fake AI generated slop as 'medical history'.
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Dr. Rishikesh Balvalli retweeted
If true, this is the worst and the most discriminatory move against Indians I have ever seen in my life! Indian investors who have been betting on India and had been holding their shares in the economy despite the struggling times we have been going through are being punished and foreign investors who pulled out money are being awarded. If you want to remove capital gains tax, remove for everyone! What is this slavery mindset with which our FM is working! Shameful! I would urge all Indian investors to pull out their money from Indian stocks if this is implemented!
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Dr. Rishikesh Balvalli retweeted
RAS finally getting drugged is one of the great stories in modern biology, and almost nobody outside oncology understands why it's such a big deal. YOU'LL LEARN SOMETHING AWESOME TODAY. i am going to keep this as understandable (and simple) as i can. OPEN THE THREAD. 🧵
Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer Seldom do you sense you’re witnessing a historic moment in cancer care but this feels like ras targeting has arrived #ASCO26
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Dr. Rishikesh Balvalli retweeted
People who don't follow cancer research often ask me why we haven't cured cancer. That perception masks a wonderful reality: We make amazing, stepwise progress every year, and the result is that many people live much longer today than they would have previously. Right now we're in the thick of the annual meeting of the American Society of Clinical Oncology, the biggest research meeting on new cancer medicines, and this morning a bunch of really important studies dropped. I'm going to review them here. This first image is the result for daraxonrasib, a treatment for pancreatic cancer that is generating consdirable excitement. The green line is the probability of living for patients who got the new drug; the gray one is the chemo control group. If you follow cancer drugs, a chart like this will make your breath hitch a little. I'm going to review these and some other data here.
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Dr. Rishikesh Balvalli retweeted
One of the most amazing things I’ve ever seen: a standing ovation for the full Daraxonrasib results I feel inspired and energised, to put it mildly — we have a targeted therapy for pancreatic cancer now, and nothing is undruggable anymore
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We need a special episode of Pariksha Pe Charcha!
PM Modi's #MannKiBaat came & went without a mention of the NEET, CBSE & CUET mess. Let's not pretend this is beneath the Prime Minister's attention. We have seen the full communication apparatus mobilised over far smaller matters. Photo ops, speeches, tweets & inaugurations for projects of purely local significance. When millions of students are affected, however, the country is expected to accept silence. Strange priorities for a nation that calls its youth its greatest asset.
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When you are the patient, you expect the doctor to spend maximum time with you. When you are in the waiting room, you expect the doctor to spend minimum time with the patient inside.
Folks complaining about Indian doctors and waiting times... ...do think about what is happening in any country outside india. Go ahead ...US? UK?Canada? Sure there is plenty to improve in our system ...but unnecessary delay is not one of the flaws. Actually doctors everywhere in the world, would NOT want their pts to wait needlessly.
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Why explain all this to a fake account?
Every single one of the points are a real problem. But your understanding is broken, let me explain. :) Norway has 55 lakh people. Total. That’s smaller than the population of Pune. Their entire country has fewer citizens than India’s 25 smallest cities individually. Norway also has 1.2 trillion dollars in sovereign wealth from oil reserves, accumulated over 50 years. They have $250,000 per citizen sitting in the fund. India has roughly $3,400 per citizen in forex reserves. Norway is what you get when a small population sits on top of one of the largest per-capita oil discoveries in human history. The right comparison is other low-income, high-population, post-colonial democracies. Brazil. Indonesia. Nigeria. Bangladesh. Pakistan. Egypt. Mexico. South Africa. Vietnam. Philippines. Compare on these and India isn’t doing badly. It’s doing better than most. UPI is the world’s largest real-time payments system. Aadhaar is the world’s largest biometric identity system. We absorbed the global pandemic, the Ukraine war, the West Asia conflict, Trump’s tariffs, the Iran war, and a rupee fall without going into recession. Most of those countries above did. Pakistan went to the IMF 24 times. Sri Lanka collapsed. Bangladesh is unstable. Egypt needed emergency Gulf bailouts. Argentina has 60% inflation. We stayed standing. India is the only country in human history to add a trillion dollars of GDP every 18 months. We added our first trillion in 2007. Our second in 2017. Our third in 2024. Our fourth coming in 2026. The problems you mentioned exist in every large, low-income, high-density country on earth. Mexico City’s pollution is worse than Delhi’s. Manila’s traffic is worse than Mumbai’s. Lagos has worse road quality than Delhi. Jakarta has worse air than Delhi. Cairo has worse adulteration. Karachi has more corruption. Hanoi has higher pollution. None of these countries are run by Modi. They’re all dealing with the same impossible math. Industrialising a country of 145 crore people during a global energy transition, with limited natural resources, while keeping democracy intact, is the single hardest governance challenge in human history. > China did it without democracy. > South Korea did it with a population one-tenth our size. > Japan did it with no major religious or linguistic diversity. > Singapore did it with 50 lakh people total. Nobody has done it at India’s scale, with our diversity, in democratic conditions. So when someone asks “why hasn’t Modi built one city like Norway,” the answer is because building one Norway requires not having 144.5 crore other Indians to look after.
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That's why we have Hangyo!
Everyday I see someone here hyping that Aamchi icecream. And apparently the brand is Gujarat based and has got nothing to do with the real "aamchis". #IYKYK
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Mine. Pune 2022.
Is there even a single person in India whose passport was made without paying a bribe? 😭 Are any of you here that lucky? And if not, how much did you have to pay?
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Dr. Rishikesh Balvalli retweeted
So now even taxanes supply is under threat. If the authorities can’t ensure that stocks of non expensive essential life saving cancer drugs are restored, request them to atleast issue an official legal order that absolves medical oncologists from the legal liability of inferior treatments and outcomes thanks to national shortage of these drugs, coz while we would very much like saving lives, when that is not facilitated by the Government and the global situation, we would very much like to atleast save our @$$! @MoHFW_INDIA @PMOIndia @JPNadda
In oncology we say one size doesn’t fit all, but if there are any drugs that work in almost all cancers, they have to be platinum drugs especially Cisplatin and Carboplatin. The simplest, effective and cheapest drugs that have no replacement in several cancers are out of stock in most hospitals in India, leaving patients and families to suffer with no treatments even in curable cancers. The global supply chain has been massively impacted, so are the import rates and manufacturing rates. While capping prices of drugs is a welcome move, flexibility that is reviewed dynamically is the need of the hour, a 50% rise in capped price of a 200 rupees drug that is life saving should be accommodated as the cost of lives lost is going to be much more. Request @narendramodi @PMOIndia @JPNadda @MoHFW_INDIA @AmitShahOffice to resolve the situation ASAP
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Going to try this. My non patient facing job restricts interaction with native Kannadigas. OTOH, the better half speaks semi fluent Kannada within 3 years of shifting to Luru!
In talking about this whole language issue. I learnt Kannada rather late in life. In Bengaluru, where one can get by perfectly well without it. I still made that effort. Now that I am running an MSME in Mysuru, the payoffs are obvious. My Kannada is not the best. But, I do have to talk to our workforce and give speeches to them. They know that I make grammatical errors. Some of them correct me gently and I learn. But they appreciate the fact that I make that effort to speak to them in their language. I think that effort is what matters.
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Dr. Rishikesh Balvalli retweeted
In oncology we say one size doesn’t fit all, but if there are any drugs that work in almost all cancers, they have to be platinum drugs especially Cisplatin and Carboplatin. The simplest, effective and cheapest drugs that have no replacement in several cancers are out of stock in most hospitals in India, leaving patients and families to suffer with no treatments even in curable cancers. The global supply chain has been massively impacted, so are the import rates and manufacturing rates. While capping prices of drugs is a welcome move, flexibility that is reviewed dynamically is the need of the hour, a 50% rise in capped price of a 200 rupees drug that is life saving should be accommodated as the cost of lives lost is going to be much more. Request @narendramodi @PMOIndia @JPNadda @MoHFW_INDIA @AmitShahOffice to resolve the situation ASAP
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