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@PennMedBenchmarks @PennMedBench

Preclinical & fundamental research at Penn Medicine. Looking at life in the dish, through the microscope, and in the cloud.

Joined May 2018
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@PennMedBenchmarks@PennMedBench
12 Jan 2023
Check out the monthly Benchmarks newsletter, featuring highlights from Penn Medicine’s advancements in preclinical and discovery science. Subscribe to receive new issues as they're released here: pennmedicine.org/news/public…
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It seems like the nose is key to keeping cold viruses severity in check pnas.org/doi/10.1073/pnas.24… @PNASNews
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Researchers using the cryo-EM facility @PennMedicine unveiled the inner workings of formins—proteins involved in functions from cytokinesis to mechanotransduction. Formin's atomic structures reveal crucial insights into their functions and role in diseases nature.com/articles/s41586-0…

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Mechanical hyperalgesia is pain from things that should feel like a gentle touch, such as clothes against the skin, but @PennMedicine researchers uncovered clues about what causes this condition to happen nature.com/articles/s41467-0… @NatureComms

Distinct local and global functions of mouse Aβ low-threshold mechanoreceptors in mechanical...

Nature Communications - The mechanism underlying mechanical hyperalgesia is not fully understood. Here authors show opposing roles of tactile afferents in mechanical nociception using mouse pain...

nature.com
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The latest sequencing of centromeres provides even more clues of how interconnected we are without primate cousins, including chimps and orangutans nature.com/articles/s41586-0…

The variation and evolution of complete human centromeres

Nature - A comparison of two complete sets of human centromeres reveals that the centromeres show at least a 4.1-fold increase in single-nucleotide variation compared with their unique flanks, and...

nature.com
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STINGing CAR Ts, our centromeres and our primate cousins, and how the nose limits how mean viruses can be: Check out our new edition of Benchmarks mailchi.mp/uphs/penn-medicin…

ALT Season 8 Wow GIF by The Office
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A pair of new biomarkers could be useful in tracking the effectiveness of therapies for multiple sclerosis, @PennMedicine scientists found @JAMANeuro jamanetwork.com/journals/jam…

Emerging Cerebrospinal Fluid Biomarkers of Disease Activity and Progression in Multiple Sclerosis

This cohort study examines data from 2 prospective multiple sclerosis cohorts to identify cerebrospinal fluid measures associated with relapsing and nonrelapsing progressive multiple sclerosis...

jamanetwork.com
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@PennMedBenchmarks retweeted
Penn Medicine
@PennMedicine
28 May 2024
An experimental #mRNA vaccine could potentially help manage the outbreak of the avian influenza virus #H5N1 currently circulating in birds and cattle in the U.S., and prevent human infections, according to research led by @SCOTTeHENSLEY and @WeissmanLab. spr.ly/6014e8XAI

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ICYMI: @PennMedicine researchers explored why liver inflammation is so critical to cancer's invasions nature.com/articles/s41590-0…
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“I’m still in shock with this discovery. People keep asking me about it, and it’s been a while, but I’m just excited. I’m thrilled.” pennmedicine.org/news/news-b…
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Cancers can manipulate telomeres, which cap DNA, to help their own spread. @PennMedicine scientists just figured out how they do it @MolecularCell cell.com/molecular-cell/abst…
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@PennMedBenchmarks retweeted
Penn Medicine
@PennMedicine
8 May 2024
A @PennOrtho team wore gyroscopic sensors around their ankles for this year’s Broad Street Run to collect data on how healthy Achilles tendons work. Dr. Casey Jo Humbyrd and Josh R. Baxter, PhD, outlined their plans for the data. spr.ly/6019jWAgF

Broad Street runners from Penn are racing with gyroscopes to study the Achilles tendon

It’s a unique opportunity for Penn researchers studying the Achilles to learn more about how this crucial tendon works.

inquirer.com
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Researchers from @PennMedicine and @ChildrensPhila convened for an #autism research symposium. Interim Dean @jonepstein1 celebrated the "quantum advances" in medicine brought about by this collaboration and expressed confidence in future breakthroughs.
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A germ-free environment was key to passing along heritable traits that didn't have to do with Darwinian-style gene mutation, a new study shows cell.com/cell-reports/fullte…

The microbiota and T cells non-genetically modulate inherited phenotypes transgenerationally

Harris et al. describe phenotypic abnormalities in germ-free and T cell-deficient mice that are not acutely correctable and are non-genetically transmitted to progeny. The parental microbe and immune...

cell.com
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Tatiana Blanchard recently earned her PhD and has begun her career training with the renowned Carl June. She shared her story and detailed work on Ewing's sarcoma biotechtv.com/post/tatiana-b…

Recent Graduate Profile: UPenn's Tatiana Blanchard

Recent PhD graduate Tatiana Blanchard shares her story as a scientist, talks about what it has been like doing research on Ewing sarcoma, and what it has been like working in the labs of mentors Dr....

biotechtv.com
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Liver inflammation linked to cancer is linked to worse outcomes, but the reason has been unclear. Now, @PennMedicine researchers believe they may have an idea of why nature.com/articles/s41590-0… @NatImmunol
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Non-genetic inheritance, a secret of liver inflammation's role in cancer spread, and a medical school curriculum for climate change. A lot to read in the latest Benchmarks: mailchi.mp/uphs/penn-medicin…
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Research can often leave out important voices, like people from underrepresented racial and ethnic backgrounds, those who speak languages other than English, or those with limited literacy. A @PennMedicine team is looking to change that. pennmedicine.org/news/news-b…
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@PennMedBenchmarks retweeted
Penn Medicine
@PennMedicine
23 Apr 2024
Congratulations to @carlhjune, awarded the @brkthroughprize in Life Sciences for the development of #CARTcelltherapy, a revolutionary cancer treatment in which a patient’s own T cells are modified to target and kill their cancer cells.
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One study says yes, another says no. So what should clinicians do? Researchers from @PennMedicine received a @PCORI to build a system to help them reconcile situations like these pennmedicine.org/news/news-b…
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@PennMedBenchmarks retweeted
Penn Medicine
@PennMedicine
17 Apr 2024
Sara Cherry, PhD, and Maayan Levy, PhD, commented on the current state of #longCOVID research and what's needed to better understand the disease, including identifying biomarkers. @PennPathLabMed @PennMicro spr.ly/6011b8t5h

Long Covid trials aim to clear lingering virus—and help patients in need

With a still-emerging understanding of the syndrome’s biology, researchers are braiding basic discoveries into treatment studies as they go

science.org
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