The Gordon center started the new year with a new biological emphasis under new leadership: @MatthiasNahrend is our new director. Umar Mahmood will lead a technology-focussed sibling, the Center for Nuclear Medicine & Theranostic Sciences.
Noninvasive Quantification of Radiation-Induced Lung Injury using a Ta... sciencedirect.com/science/ar…. Great collaboration with Eric Abston and @MGHSurgery on using #MolecularImaging for early detection of radiation induced #fibrosis and monitoring treatment response
This paper from @Mariane_LeFur had 3 provocative findings. 1. Gadolinium retained in kidneys is invisible to T1w MRI until it is present at high 100s of micromolar. Gd is retained in kidneys at several orders of magnitude more than in brain. #Kidney 1/6
Following administration of four different gadolinium contrast agents to healthy rats, mass spectrometry showed the highest concentration in the kidney cortex at day 17. @PeterCaravan @Mariane_LeFur @MGHMartinos @MGH_RI @i3MGHbit.ly/3FsC8ze
3. At 7-8 weeks after dosing the gadolinium retained in the rat kidneys was intact chelate. This was true of all 4 compounds tested including the linear chelate gadobenate. 5/6
Despite all that Gd, there were no histological signs of kidney damage. Would be worth testing if this is true in older rats or those with prior kidney injury. End
Nice work from Phil and Iris and a great collaboration with Bryan Fuchs, Bob Colvin @MGHKidneys and @pfizer colleagues to image fibrotic disease activity in the kidneys
In most CKDs, lysyl oxidase oxidation of collagen forms allysine side chains, which then form stable crosslinks. This study shows MRI using Gd-OA is potentially a valuable tool for detecting and staging renal fibrogenesis bit.ly/JASN0148@PeterCaravan@i3MGH
ALT Gd-OA detects fibrogenesis in the NTN mouse model.
Great symposium today at #NERM2023 honoring the legacy of Saul Hertz. Remarkable man. The speed of translating innovations in particle physics to clinical practice was inspiring. @MGH_RI Great to hear my mgh colleagues @jmhooker@AileenO_Shea AnnaLiisa Brownell.
This week's MIB Paper of the Week focuses on receptor tyrosine kinase inhibitors, their role in tumorigenesis, and using HER3 PET imaging in gastric cancer models. Great work by @ShadiEsfahani et al.! ow.ly/VE5p50OMjY2@MGHImaging