Cryo-electron microscopy, structural biology of molecular machines, ribosome-associated processes
Joined October 2020
- Tweets 82
- Following 117
- Followers 547
- Likes 101
1 Photos and videos
22 Aug 2025
We are excited to share our latest work elucidating the structural basis for how augmin binds to microtubules. Out just now @NatureComms:
nature.com/articles/s41467-0…
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22 Aug 2025
Nearly two decades after augmin's discovery in Drosophila, we have reconstituted the microtubule-binding region of the Drosophila augmin complex on microtubules and demonstrate the conserved mechanism by which the augmin subunit HAUS6 orients augmin for microtubule branching.
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22 Aug 2025
Congratulations to the shared first authors @martin_wuertz and Giulia Tonon! Fantastic collaboration with the Schiebel Lab @ZmbhH, @FabioLolicato at the BZH Heidelberg, @EustermannLab @embl, and the Erhardt Lab at KIT Karlsruhe. Thanks to all who contributed!
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21 Mar 2025
Out just now at @NatureComms: using cryo-EM and cryo-electron tomography, we provide evidence that structurally heterogeneous ribosomes can cooperate in protein synthesis in bacterial cells:
nature.com/articles/s41467-0…
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21 Mar 2025
Great collaboration with the Melnikov Lab @SergeyVMelniko1 @UniofNewcastle and the Hill Lab @chillzaa @YBRI_UoY. Congratulations to all authors, in particular the shared first authors Karla Helena-Bueno and Sophie Kopetschke @S_Kopetschke.
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Stefan Pfeffer retweeted
20 Mar 2025
1/2 Here we unexpectedly find that protein S20/L26—identified at the dawn of ribosome research but then deemed a ribosome isolation artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation: nature.com/articles/s41467-0…
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12 Mar 2025
Online today at @NatureComms: in a major team effort, we reveal the structural mechanisms for centrosomal recruitment and organization of the human microtubule nucleator γ-TuRC: nature.com/articles/s41467-0…
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12 Mar 2025
A great collaboration with the Schiebel Lab @Zmbhh
@UniHeidelberg and the Gruss Lab @UniBonn. Congratulations to all authors, in particular the shared first authors Qi Gao, Florian Hofer, Bram Vermeulen @BramV98 and Sebastian Filbeck!
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6 Jan 2025
Out just now at @NatureComms and a great start into the New Year: we reveal how yeast cytoplasmic γ-TuRC is assembled and activated by dimeric CM1 motifs of the receptor protein Spc72 and how the microtubule polymerase Stu2 binds to promote MT assembly. nature.com/articles/s41467-0…
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6 Jan 2025
Great collaboration with the Schiebel and Mayer Labs @Zmbhh @UniHeidelberg. Congratulations to all authors, in particular the shared first authors Anjun Zheng, Bram Vermeulen @BramV98
and Martin Würtz @martin_wuertz.
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Stefan Pfeffer retweeted
Congratulations to Martin Würtz, who yesterday received the Nikon Young Scientist Award 2024 for excellent research in cell biology awarded by the German Society for Cell Biology.
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7 Oct 2024
We have an open PhD position to explore structures of gamma-tubulin ring complexes using cryo-EM approaches here in our group @ZmbhH
@UniHeidelberg.
Please apply via the Heidelberg Biosciences International Graduate School @HBIGS_HD : hbigs.uni-heidelberg.de
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10 Jun 2024
We still have open PhD positions here in our cryo-EM group @ZmbhH @UniHeidelberg.
Please apply via the Heidelberg Biosciences International Graduate School or directly send us your application documents.
hbigs.uni-heidelberg.de/
10 May 2024
We have two open PhD positions to explore structures of ribosomes and gamma-tubulin complexes using cryo-EM approaches here in our group @ZmbhH @UniHeidelberg.
Please apply via the Heidelberg Biosciences International Graduate School @HBIGS_HD: hbigs.uni-heidelberg.de/
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10 May 2024
We have two open PhD positions to explore structures of ribosomes and gamma-tubulin complexes using cryo-EM approaches here in our group @ZmbhH @UniHeidelberg.
Please apply via the Heidelberg Biosciences International Graduate School @HBIGS_HD: hbigs.uni-heidelberg.de/
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11 Apr 2024
Out just now @embojournal: our cryo-EM structure of the native RanGTP-induced γ-TuRC-capped microtubule, revealing a surprisingly asymmetric minus end architecture with direct implications for microtubule regulation and modulation during spindle assembly.
embopress.org/doi/full/10.10…
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11 Apr 2024
Great collaboration with the Schiebel Lab @Zmbhh @UniHeidelberg and the Gruss Lab @UniBonn. Congratulations to all authors, in particular the shared first authors Bram Vermeulen @BramV98, Anna Böhler and Qi Gao @QIGAO31314616.
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1 Feb 2023
We still have ERC-funded PhD positions open in the lab! If you are interested, please apply!
23 Nov 2022
We have three open PhD positions funded under our #ERCStG 'RiboStress' to explore how cells remodel the activity and molecular organization of the translation machinery in response to stress.
If you are interested apply via the HBIGS graduate program: my-hbigs.uni-heidelberg.de/s…
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23 Nov 2022
We have three open PhD positions funded under our #ERCStG 'RiboStress' to explore how cells remodel the activity and molecular organization of the translation machinery in response to stress.
If you are interested apply via the HBIGS graduate program: my-hbigs.uni-heidelberg.de/s…
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Stefan Pfeffer retweeted
If you want to read a short summary of the projects of the three new @ERC_Research Grantees #ERCStG Daniela Duarte Campos, Kerstin Göpfrich @KGoepfrich, and Stefan Pfeffer @PfefferCryoLab based @ZmbhH visit:
uni-heidelberg.de/en/newsroo…
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Stefan Pfeffer retweeted
22 Nov 2022
Fünf ERC Starting Grants gehen an die Universität Heidelberg – Europäischer Forschungsrat fördert Vorhaben in der Molekularen Biologie, der Malaria-Forschung und der Astronomie mit insgesamt rund 7,5 Millionen Euro uni-heidelberg.de/de/newsroo…
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