23-Advice to a young scientist (by someone who doesn't know how to give it)
by @denic_lab
2017
Unbelievably inspiring and well-written
molbiolcell.org/doi/full/10.…
ALT "This was not the first molecular biology paper that I read, but it was the first that made me dream"
Probably the best introductory sentence to research focus on a lab page:
"We are interested in just about everything. But the brevity of life being what it is compels selectivity."
-Alexander J. Varshavsky's lab
#quotestoliveby#Sciencebbe.caltech.edu/people/alexa…
Refreshing to know that someone speaks your language:
lifescivc.com/
Thanks @LifeSciVC for normalizing sciencetalk (using science analogies in everyday discussions), and for the advice.
#Science#sciencetwitter
1/Day 2 of the B cell: T cell collaboration 🔑🪨
My favorite talk (by far) was the tour de force set of studies presented by Mark Shlomchik regarding "heterogeneity, ontogeny, and functions of memory B cells"
#immunology#KSBcellTcell22
1/Where do I start?
Is it at Von Behring and Kitasato who were the first to discover that immunization of animals with diptheria and tetanus toxins resulted in soluble substances in the serum that neutralize these same toxins making them harmless?
bit.ly/VonBehring1890
ALT From "The generative grammar of the immune system" by Niels K Jerne (EMBO, 1985) PMID: 2410261
Also see his Nobel lecture of the same title.
1/Where do I start?
Is it at Von Behring and Kitasato who were the first to discover that immunization of animals with diptheria and tetanus toxins resulted in soluble substances in the serum that neutralize these same toxins making them harmless?
bit.ly/VonBehring1890
ALT From "The generative grammar of the immune system" by Niels K Jerne (EMBO, 1985) PMID: 2410261
Also see his Nobel lecture of the same title.
23/
All these changes happen BEFORE they develop secretory function (these pre-PCs are not Blimp1 (Prdm1) or have the canonical PC phenotype)
Supporting earlier work by Kurosaki and co.
bit.ly/Ise18
24/ Anyway, this is most of what I think is worth tweeting here.
There was also an attempt to delve into whether BCR signaling helps higher-affinity GC B cells become PCs and it does, but BCR signaling helps all B cells.
🫤