Twitter feed for the laboratory of Prof. Kathrin Plath @UCLA
Joined June 2019
- Tweets 116
- Following 168
- Followers 956
- Likes 54
25 Photos and videos
📢 Ready to rethink XIST? Our latest work, now in Cell, challenges two fundamental assumptions about XIST: its cis-limited action, and its role in equalizing gene expression between XX and XY genotypes.
Dive in 👇🤿(1/6)
sciencedirect.com/science/ar…
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Plath Lab retweeted
22 May 2024
Excited to share our latest work: L126 fine-tunes enzymatic activity of histone H3, a discovery made possible by viewing the nucleosome as an enzyme. We have a gain-of-function mutant – it’s hard to enhance an activity if it doesn’t already exist! sciencedirect.com/science/ar…
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Plath Lab retweeted
22 Mar 2024
I'm delighted to have been mentioned in the celebratory article commemorating the 30th anniversary of NSMB #Xist_granules #phase_separation @tartaglialab @mitchguttman @PlathLab @NatureSMB nature.com/articles/s41594-0…
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Applying RAP-seq, we found that XIST spreads across the X and, surprisingly, also to autosomal genes. Autosomal targets show female-specific and XIST-dependent H3K27me3 and downregulation of gene expression, indicating that XIST enforces sex differences on autosomes. (3/6)
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One of the most extensively studied lncRNAs continues to surprise us! A huge thanks to everyone who helped with this! @Iris_Dror @tsotnech @ClaraCanCanoe @Dr_Sahakyan @YolandaMarkaki @ChronisLab @Mandy_Collier @WeixianDeng @DingFangyuan, #lncRNA, #SexDifferences (6/6)
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📢 Ready to rethink XIST? Our latest work, now in Cell, challenges two fundamental assumptions about XIST: its cis-limited action, and its role in equalizing gene expression between XX and XY genotypes.
Dive in 👇🤿(1/6)
sciencedirect.com/science/ar…
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Check out our latest publication where we developed SEC-seq – a new technology that captures and measures single-cell protein secretion coupled with mRNA transcriptomes published in Nature Nanotechnology! nature.com/articles/s41565-0…
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In collaboration with @dinodicarlo, we used hydrogel nanovials to capture and measure the secretion of VEGF-A alongside mRNA transcriptomes. Surprisingly, we found that the VEGFA transcript was not the best predictor of secretion! 2/2
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Congratulations to Plath lab member @JustinLangerman who was awarded the UCLA 2023 Boyer/Parvin Postdoctoral Award. 🎉
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Plath Lab retweeted
27 Jan 2023
Join us for this incredible @GordonConf on #StemCells and #Cancer in beautiful #Tuscany organized with @CedricBlanpain and @PlathLab!!🔬🧐🇮🇹
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It's time to bring single cell secretion measurement into the multiomics family! Check out our recent BioRxiv submission where we found unexpected relationships between VEGF-A secretion, the VEGFA mRNA, and the cell state: biorxiv.org/cgi/content/shor…
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Plath Lab retweeted
29 Sep 2022
I’m happy to share our new paper with @LabMomoko published today cell.com/stem-cell-reports/f… which examines how differences in the state of human stem cell pluripotency can lead to favorable or unfavorable outcomes when making brain organoids.
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Congratulations to @YolandaMarkaki and all other award winners for the UCLA 2022 Boyer/Parvin Postdoctoral Award. Tune in for her seminar on "How to silence a chromosome" July 20th at 12PM PT. 🧬
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Plath Lab retweeted
7 Jul 2022
It’s finally out! Many thanks to my colleagues @jacksongcheng and my mentor Andy McMahon at USC for making this happen. #organoid #kidney #screen
7 Jul 2022
In a @CellStemCell study, scientists from the @USCStemCell lab of Andy McMahon generated kidney-like structures called organoids, and used them to identify potential drugs for adult-onset polycystic kidney disease. @TTdevbio @jacksongcheng @KECKSchool_USC stemcell.keck.usc.edu/mini-k…
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Excited to share our recent review on the role of Xist in maintaining X inactivation!
sciencedirect.com/science/ar…
By @Elsie_youlater and Amy Pandya-Jones
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Plath Lab retweeted
19 May 2022
Happy to share our most recent paper (1/3):
FGFR3 is expressed by human primordial germ cells and is repressed after meiotic initiation to form primordial oocytes cell.com/stem-cell-reports/f…
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Plath Lab retweeted
8 Apr 2022
We are excited to host @DrPlattLab from @GeorgiaTech as part of our Scientific Excellence Through Diversity Seminar (SEDS) series. Join us Thursday, April 14th at 4pm in Boyer 159 for Dr. Platt’s seminar, which will be followed by a reception in the Boyer Hall Patio.
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