Ion Channel Biophysics, K Channels, OXION PhD programme, @UniofOxford @OxfordPhysics @KavliOxford etc... Find me now on Bluesky....
Joined January 2017
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Do not forget to submit an oral abstract for 8th RSC-BMCS / SCI Symposium on Ion Channels as Therapeutic Targets!
This symposium will showcase the most recent advances to aid the design of new ion channel therapeutics and promote interaction between scientists with a shared interest in the field of ion channel drug discovery. 🙌
Click here to submit an abstract 👇
lnkd.in/eQXsgHcP
🗓️Deadline: 15th November
#IonChannels25
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6 Aug 2024
Want to know when is a hydrophobic gate not a hydrophobic gate? Read more here in this Viewpoint:
rupress.org/jgp/article/154/…
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Stephen J. Tucker retweeted
6 Aug 2024
Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease biorxiv.org/cgi/content/shor… #biorxiv_biophys
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6 Aug 2024
Our latest Preprint: More new CryoEM structures of TASK1 and TASK3 @K2pChannels including the G239R disease-causing mutant structure of TASK3 (KCNK9 Imprinting Syndrome/Birk Barel Syndrome)
biorxiv.org/content/10.1101/…
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14 Jul 2024
I’m so glad at least one moment of this was captured for posterity. Fred is one of the true pioneers in the field and this was simply one of the most amazing talks I have heard.
12 Jul 2024
History of ion channels by one of his authors. Fred Sigworth’s closing seminar at the GRC was simply beautiful
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Stephen J. Tucker retweeted
20 Jul 2024
One of the unforgettable moments at the 2024 Ion Channels GRC was the closing lecture by Fred Sigworth. If you missed it, here it is.. youtu.be/db1afWzokOU?si=hyCJ…
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18 Jul 2024
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10 Jul 2024
I feel hungry after just a few hours, but hibernating squirrels don't even after several months. This remarkable feat is possible due to reversible central hypothyroidism. A new study from the Gracheva lab by Sarah Mohr and @rafaeldaipra
rdcu.be/dNmeC
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27 Jun 2024
Exciting times for @K2pChannels indeed!
27 Jun 2024
Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site biorxiv.org/content/10.1101/…
New work from our lab shows a hydrophilic gate (the flow restrictor) and polyunsaturated fatty acid site. See also work from @ProfKalium
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27 Jun 2024
Our latest Preprint on structure of THIK-1 K2P Channel - lots of new features including a lower 'Y-gate'.
biorxiv.org/content/10.1101/…
Also exciting that Dan Minor's group @ElectrosomeUCSF have almost identical results and some additional structures - also on @biorxiv_biophys
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16 May 2024
Our latest paper on Extracellular modulation of TREK2 K2P channels by nanobodies is now finally online in @NatureComms
nature.com/articles/s41467-0…
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23 Mar 2024
"A fundamental mistake in receptor theory has led to an enduring misunderstanding of how to estimate the affinity and efficacy of an agonist."
arxiv.org/abs/2402.14617
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5 Mar 2024
Matthew Freeman and Fran Ashcroft discuss "The Mould in Dr Florey's Coat" by Eric Lax in this #podcast
podcasts.ox.ac.uk/good-scien…
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Stephen J. Tucker retweeted
28 Feb 2024
I am sad to report that Bill Catterall has died. He was an enormous presence @UW.
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14 Feb 2024
A mechanism of lysosomal calcium entry | Science Advances science.org/doi/full/10.1126…
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Stephen J. Tucker retweeted
14 Jan 2024
The key here was to include native acyl chain length PIP2 (not PIP2-diC8).
11 Jan 2024
Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface | bioRxiv
biorxiv.org/content/10.1101/…
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13 Jan 2024
Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis | Nature nature.com/articles/s41586-0…
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