We make people (and technology) better at Mount Sinai. Opinions are my own.
Joined June 2014
- Tweets 9,389
- Following 406
- Followers 36,327
- Likes 15,302
484 Photos and videos
Pinned Tweet
12 Sep 2022
With some new followers on board, I wanted to take the time to re-introduce myself to the #LongCovid community (and everyone else). Iām David Putrino: Director of Rehab Innovation at @MountSinaiNYC, Associate Prof at @MountSinaiRehab for @IcahnMountSinai 1/
79
133
1,127
A thread today about Immunoglobulin G (IgG) antibodies to various pathogens and why they seem to be elevated a lot in people with #LongCOVID, #MECFS, chronic #lyme/tick- and vector-borne illnesses and other complex chronic illnesses. First, let's start basic: what is IgG?
1/
7
83
270
11,359
more susceptible to molecular mimicry and we know these variants to be overrepresented in #LongCOVID, #MECFS, #fibromyalgia and some primary autoimmune diagnoses. And many other genes that affect immune function as well have been seen to cause a propensity for an outsized IgG
24/
2
2
43
1,169
response to herpesviruses: TNF-alpha promotor genes, IL-6 and IL-10 promoter genes, IRF5, STAT4, KIR, C4A and probably more.
TLDR: An abnormally elevated set of herpesvirus titers in a chronically ill person should be the START of a detailed investigation, not the end. š
/end
6
11
92
1,354