🔬🧠 Our paper revealing how loss of neuronal SFPQ impacts the axonal transcriptome and it’s relavence to ALS is out now in @NatureComms
A huge thank you to all who contributed and provided help/support along the way 😀 @HouartLabnature.com/articles/s41467-0…
Professor Corinne Houart and Dr Richard Taylor (part of @UKDRI at King's) received a new £500k grant from @AlzResearchUK to study how RNA-binding proteins, which are disrupted in #dementia, might be important for protecting against degeneration.
🚨Meet the latest early career researchers awarded Race Against Dementia Fellowships🚨
These rising stars are challenging old ideas and driving bold new approaches to speed up progress @RNA_Richard@SorayaMeftah@Neurowland
Our review discussing the diversity of RNA types that localise to different parts of the neuronal periphery and the local regulation they undergo has just been published! 😃😃 @nikolas_neurofrontiersin.org/articles/10.…
Our new findings 👀 Combining zebrafish and human iPSC models of FOXG1 Syndrome we uncover a role for FOXG1 in the cytoplasm, where it controls mitochondrial translation, integrating cell fate decisions and regulation of metabolic activity. @CorinneHouart@HouartLab
A cleaved cytosolic FOXG1 promotes excitatory neurogenesis by modulation of mitochondrial translation - a new therapeutic target for ... biorxiv.org/cgi/content/shor…#biorxiv_neursci
Our protocol for performing primary culture of zebrafish neurons has been published.
It includes details on using transwell inserts, allowing for the isolation of neurites 😃 @CorinneHouart@HouartLablink.springer.com/protocol/1…
Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS nature.com/articles/s41467-0…
Interesting new hypothesis for motor degeneration in ALS "These new findings not only challenge the dogma that prematurely terminated mRNAs are targeted for degradation but offer novel insights into the mechanisms underlying ALS and possibly other neurodegenerative conditions."
🔬🧠 Our paper revealing how loss of neuronal SFPQ impacts the axonal transcriptome and it’s relavence to ALS is out now in @NatureComms
A huge thank you to all who contributed and provided help/support along the way 😀 @HouartLabnature.com/articles/s41467-0…
🔬🧠 Our paper revealing how loss of neuronal SFPQ impacts the axonal transcriptome and it’s relavence to ALS is out now in @NatureComms
A huge thank you to all who contributed and provided help/support along the way 😀 @HouartLabnature.com/articles/s41467-0…
New research reveals a new hallmark for #ALS, shedding light on a likely trigger of neurodegeneration.
Researchers found that loss of the RNA processing protein, SFPQ, in motor neurons results in their ‘dying back’ .
Read more below.
#IoPPNNewsbuff.ly/3EtrIyu