Joined May 2016
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22 Photos and videos
Richard Jenner retweeted
Excited to share the first pre-print from our lab!!
Check it out here! biorxiv.org/content/10.64898…
We found that many RNA-binding proteins understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.
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Richard Jenner retweeted
Independent Senior Research Fellow position available! Working between UCL and UCLH, you will apply machine learning to digital pathology data and electronic health records to drive new insights in cancer biology and improve patient care.
To apply: lnkd.in/e9SX6WAT
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May 27
Does PRC2 interact with RNA or is it an artefact? See our preprint showing how stringent denaturing purifications with spike-in controls support direct interaction between PRC2 and RNA in cells. biorxiv.org/content/10.64898…
ALT UV-crosslinked human cells containing Halo-tagged EZH2 were mixed with crosslinked mouse cells in which the protein was untagged and human EZH2 purified with Halo resin. Enrichment of human RNA (left) or mouse RNA (right) versus input was plotted against RNA abundance in the paired input sample. Windows with significant enrichment (p <10−6; binomial test) are shown in red. Human RNAs show enrichment versus input whereas mouse RNAs do not.
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Richard Jenner retweeted
May 15
Now out in @NatureBiotech ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones. nature.com/articles/s41587-0…
12 Nov 2025
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our @MicahGoldrich and Louis Delhaye from @pieter_mestdagh. TL;DR we show that many of lncRNA chromatin occupancy maps are flawed🧵biorxiv.org/content/10.1101/…
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Richard Jenner retweeted
Computational analysis is playing an ever increasing role in the detection, management and understanding of cancer.
Equip yourself with the knowledge and skills to lead work in these areas with our new MSc in Computational Cancer, run with @UCLmedphys
ucl.ac.uk/prospective-studen…
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Mar 17
Looking forward to hosting the next meeting of the London RNA Club on RNA Regulation in the Nucleus.
Wednesday 25th March at UCL.
Speakers including @BrockdorffLab, @Vichaico, @RobertVendramin and Folkert van Werven.
eventleaf.com/e/LondonRNAClu… to register.
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Richard Jenner retweeted
We’re excited to kick off 2026 with a joint meeting with the London RNA Club, featuring Mary Ann Allen and @stojic_lovorka!
🗓 Wednesday, February 25, 2026
⏰ 10:00 AM MST
📍 Zoom: please RSVP here for link: docs.google.com/forms/d/e/1F…
Supported by @RNASociety
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Richard Jenner retweeted
To RNA aficionados! We are organising the @GenSocUK meeting “RNA in Physiology and Disease" in Newcastle from 7- 9 Sept. Many opportunities for short talks and an excellent line-up of speakers. More info👇
genetics.org.uk/events/rna-i…
Please share🙏
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Richard Jenner retweeted
H3K79me2/3 is sufficient to antagonise PRC1 nature.com/articles/s41556-0…
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Richard Jenner retweeted
12 Nov 2025
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our @MicahGoldrich and Louis Delhaye from @pieter_mestdagh. TL;DR we show that many of lncRNA chromatin occupancy maps are flawed🧵biorxiv.org/content/10.1101/…
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24 Oct 2025
@UCLHresearchand & @uclcancer are recruiting an independent Research Fellow and Clinical Training Fellow.
Research areas: Cancer Immunotherapy, Early Diagnosis, Tumour Heterogeneity and Targeted Therapy and Non-chemo Treatments
ucl.ac.uk/work-at-ucl/search…
ucl.ac.uk/work-at-ucl/search…
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10 Oct 2025
Interested in applying your molecular biology skills to improve tumour immunotherapy?
@CRUKCOLcentre PhD studentship available in my lab @uclcancer in collaboration with @diunguyen_vn_uk @Bartscancer
For more information and to apply: colcc.ac.uk/phd-studentships…
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Richard Jenner retweeted
17 Sep 2025
Are you looking for a Clinical Research Training Fellowship? Do you want join our team working in cancer immunology and immunotherapy? Check this great opportunity from @CRUKCOLcentre
colcc.ac.uk/clinical-researc…
and contact our team to discuss our proposed project
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12 Sep 2025
Pleased to share our preprint describing a central role for post-transcriptional processes in the response to cancer immunotherapy. Huge amount of work led by Maria Vila de Mucha and @julia_hlond in collaboration with @QuezadaLab and @MartT_babraham 1/8
biorxiv.org/content/10.1101/…
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12 Sep 2025
Constitutive expression of Zfp36l1 in T cells nullified anti-tumour responses while knocking out Zfp36l1 and its paralogue Zfp36 released the block to GzmB protein production and promoted tumour control. 7/8
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12 Sep 2025
This work reveals mechanisms that regulate CD4 TCTX function in tumours and highlights the potential therapeutic utility of targeting post-transcriptional regulatory pathways in T cells for the treatment of cancer. 8/8
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