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Chen Davidovich @DavidovichLab

Gene repression, RNA and all chromatin things. @MonashUni @EMBLAustralia

Joined July 2017
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Chen Davidovich@DavidovichLab
Mar 5
1/ 🧵 In our new paper, we show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2. cell.com/molecular-cell/full…

Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains

Some proteins mimic the repressive mark H3K27me3, but the physiological relevance of this phenomenon was unclear. Agius et al. show that the PRC2 subunits JARID2 and PALI1 mimic H3K27me3 to antagon...

cell.com
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Chen Davidovich retweeted
The Lewis Lab@PeterLewisLab
Jun 8
Allosteric activation of PRC2 is coupled to adoption of the compact state. Our new bioRxiv manuscript shows that EZH2 S21-phos, adjacent to the SANT1 domain, restrains this conformational transition and limits activation. @vignesh_k757 & Ben Garcia lab tinyurl.com/4369kmh2
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Cell@CellCellPress
Mar 23
In the latest issue! RNA modifications in gene regulation: Functions and pathways dlvr.it/TRfPlf

RNA modifications in gene regulation: Functions and pathways

RNA is frequently chemically modified, with over 170 types of chemical modifications identified to date in cellular RNAs. These modifications, along with their effector proteins, constitute new...

cell.com
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RT @TeifLab: Nucleosome aficionados! Our new review "Nucleosome spacing across cell types, diseases, and ages" is out in NAR: t.co/…
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Chen Davidovich retweeted
Molecular Cell@MolecularCell
Mar 4
Online Now: Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains dlvr.it/TRJ2mB
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1/ 🧵 In our new paper, we show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2. cell.com/molecular-cell/full…

Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains

Some proteins mimic the repressive mark H3K27me3, but the physiological relevance of this phenomenon was unclear. Agius et al. show that the PRC2 subunits JARID2 and PALI1 mimic H3K27me3 to antagon...

cell.com
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5/ We propose that H3K27me3 mimicry has repeatedly emerged during evolution as a mechanism to antagonise PRC2 and restrict the spread of Polycomb domains.
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6/ A fantastic collaboration between the @DavidovichLab and the @Eddy_McGlinn labs, led by a brilliant PhD student, @SamAgius0, who is now looking for a postdoc position!
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Gantier Lab@GantierLab
Feb 10
I am delighted to share our characterisation of natural antagonism of TLR7/8 in Nature Immunology. We propose a model where 2’O-Methyl RNA fragments keep TLR7/8 in check, preventing autoimmunity. > nature.com/articles/s41590-0…

2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity

Nature Immunology - Here, the authors show that 2’-O-methylated RNA fragments from ribosomal RNA naturally block TLR7 and TLR8, helping to avoid avoid harmful self-RNA detection and...

nature.com
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H3K79me2/3 is sufficient to antagonise PRC1 nature.com/articles/s41556-0…

DOT1L provides transcriptional memory through PRC1.1 antagonism

Nature Cell Biology - Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy...

nature.com
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Chen Davidovich retweeted
Jun Cheng@s6juncheng
Jan 28
AlphaGenome paper and models are out today! nature.com/articles/s41586-0…. We have seen great community engagement since we released the API. We hope to open more use cases with the model weights! github.com/google-deepmind/a… We updated the supplementary note with some very interesting case studies. I encourage everyone using AlphaGenome for non-coding variant interpretation to read it. It was a huge team effort, I’m very proud of all of our co-authors @googledeepmind!
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Eduardo Eyras@EduEyras
Jan 28
Excited to share our latest preprint: "SWARM: A Single-Molecule Workflow for High-Precision Profiling of RNA Modifications" biorxiv.org/content/10.64898… Led by @StefanProdic et al. #RNA #Epitranscriptomics #Nanopore 1/6

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1/ It's long been assumed that AEBP2 recruit PRC2 to chromatin. Now, we show that AEBP2 usually does the exact opposite: The only isoform of AEBP2 that is expressed in most cell types and tissues inhibits the chromatin-binding activity of PRC2. embopress.org/doi/full/10.10…

Auto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2

The EMBO Journal - Polycomb Repressive Complex 2 (PRC2) is an essential chromatin regulator responsible for mono-, di- and tri-methylating H3K27. Control of PRC2 activity is a critical process in...

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2/ Done in collaboration with the lab of @adrianbracken, who wrote a great 🧵 explaining the work. x.com/adrianbracken/status/1…

Adrian Bracken@adrianbracken
31 Oct 2025
1/ 🚀 AEBP2 isn’t what we thought. You were told that AEBP2 promotes PRC2 activity on chromatin. We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity. Excited to share our new paper surl.li/cgwqcq A thread 🧵
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Adrian Bracken@adrianbracken
31 Oct 2025
1/ 🚀 AEBP2 isn’t what we thought. You were told that AEBP2 promotes PRC2 activity on chromatin. We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity. Excited to share our new paper surl.li/cgwqcq A thread 🧵
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James Nolan@JMNolan89
16 Oct 2025
🧵1/Exciting news in cancer epigenetics! Our latest research, "AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma", is now available on biorxiv.org/content/10.1101/…. Here's a thread with our findings!👇 #CancerResearch #Epigenetics #Chromatin #Lymphoma

AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma

The catalytic subunit of Polycomb Repressive Complex 2 (PRC2), EZH2, is recurrently mutated in 25% of diffuse large B-cell lymphomas (DLBCL), causing increased H3K27me3 and decreased H3K27me2 levels....

biorxiv.org
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Chen Davidovich retweeted
Mathias L. Nielsen@_MathiasLN
25 Aug 2025
Thrilled to see this out in @MolecularCell Led by the fantastic @sulteavn 👏 Revealing how PRC2 accessory proteins polymerise and shape gene regulation 🧬🌱 cell.com/molecular-cell/full…

VEL-dependent polymerization maintains the chromatin association of Polycomb proteins for the...

Schulten et al. show that VEL polymerization domains produce higher-order protein assemblies to maintain chromatin association of Polycomb proteins, enabling a stable epigenetic switch at the floral...

cell.com
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Chen Davidovich retweeted
Eric Joyce@ericjoycelab
14 Aug 2025
🚨New preprint from the lab🚨 🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK. biorxiv.org/content/10.1101/…

Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide...

The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their...

biorxiv.org
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