I got tired of checking whether my local AI agent was done.
So I gave it a tiny desk screen.
Now I can glance over and see:
running, done, active, or waiting for me.
AI feels different when it becomes a small physical object on your desk.
🧬 AI for Science: From First Principles to a New Research Paradigm
A personal perspective on why 2026 is the inflection point for AI-driven biomedical discovery.
WHY: Science is bounded by the gap between data we generate and understanding we can extract. AI changes what science is possible.
#AIScience#BiomedicalAI#FifthParadigm
🧠 FORCE 2: Generative Design
AlphaFold3 RFdiffusion → de novo protein design in minutes. LLM Agents autonomously execute research pipelines. Foundation models generalize across experiments, species, and conditions.
🏥 FORCE 3: Bench to Bedside
Insilico rentosertib: first AI-discovered drug completing Phase IIa. 200 AI programs in development.
WHAT: The Fifth Paradigm
AI learns patterns from data → generates hypotheses → designs experiments → simulates outcomes. A closed-loop synthesis of all prior scientific paradigms.
For the biomedical researcher: your next experiment may be designed by an AI agent that has read 10,000 papers you haven't.
Not hype. First-principles grounded in peer-reviewed data. 🔬🤖
🧬 AI for Science: From First Principles to a New Research Paradigm
A personal perspective on why 2026 is the inflection point for AI-driven biomedical discovery.
WHY: Science is bounded by the gap between data we generate and understanding we can extract. AI changes what science is possible.
#AIScience#BiomedicalAI#FifthParadigm
🏥 FORCE 3: Bench to Bedside
Insilico rentosertib: first AI-discovered drug completing Phase IIa with peer-reviewed efficacy. 200 AI programs now in clinical development. Foundation models extend to 3D CT/MRI. AI in EHR for diagnosis & trial matching.
2026: AI-designed molecules in human patients.
WHAT: The Fifth Paradigm
AI learns patterns from data → generates testable hypotheses → designs experiments → simulates outcomes — all in a closed loop. The synthesis of all four prior scientific paradigms.
For the biomedical researcher: your next experiment may be designed by an AI agent that has read 10,000 papers you haven't.
Not hype. First-principles grounded in peer-reviewed data.
Welcome to the Fifth Paradigm. 🔬🤖