We study virus-host evolution. Molecular mechanisms of virus host range and virulence. Poxviruses, arboviruses and more.

Joined January 2019
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(1/6) Our new paper is out (OA): Host species-specific activity of the poxvirus PKR inhibitors E3 and K3 mediate host range function | Journal of Virology journals.asm.org/doi/10.1128… It took 15 years from our initial discovery that human and mouse PKR were sensitive, whereas ...
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New publication from my lab further elucidated the molecular basis for the host and virus-specific inhibition of PKR. mdpi.com/3608128
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Stefan Rothenburg retweeted
The right way to remember Jim Watson is to remember him honestly. He was a central figure in one the 20th century's most impactful scientific discoveries, in the creation of modern molecular biology, in the beginning of the genomics era, and (less notably) to shaping the structures of contemporary academic departments and institutions. His actions with respect to Rosalind Franklin are certainly not beyond reproach, but the reduction of him in many peoples' minds to someone who stole her discovery is unfair and does little service to the truth. He could be charming and insightful in person, but also quick to demean people around him for seemingly no other reason than that he could. He spoke out frequently against unscientific thinking, yet also frequently said things that were unambiguously - and it often seemed intentionally - sexist, racist and anti-Semitic. The talk I saw him give at Berkeley 20 ish years ago, while perhaps designed primarily to provoke, was a masterclass in how to undermine your own reputation as a person and a thinkier. His demise was sad, but also self-inflicted in a way that someone as smart as he thought he was should have known to avoid. I know many won't mourn him - and that is fine - but I will because I think he and his generation of scientists made science a more interesting - if not always a better - place.
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Poxvirus structural biology for application to vaccine design sciencedirect.com/science/ar…

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For all the doubters. Here you have it. Stay strong 🇺🇸. “ONLY THE WEAK WILL FAIL”! abcnews.go.com/Politics/live…
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Stefan Rothenburg retweeted
🚨 Big news! Infection and Immunity is now open access! 🌍🔬 That means wider visibility & impact for your research. Worried about fees? 💸 Check out how IAI stacks up against other journals—you might be surprised. #OpenAccess #SciComm #Microbiology
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Timely review from poxvirus gene regulation expert Zhilong Yang and colleagues. #poxviruses Temporal expression classes and functions of vaccinia virus and mpox (monkeypox) virus genes | mBio journals.asm.org/doi/10.1128…

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Important paper demonstrates host-species specific inhibition of IFIT1 by different #poxviruses. A poxvirus ankyrin protein LSDV012 inhibits IFIT1 in a host-species-specific manner by compromising its RNA binding ability: dx.plos.org/10.1371/journal.…

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Stefan Rothenburg retweeted
Thrilled to share our latest manuscript evaluating exon skipping ASO strategies for CF! Years of hard work and fantastic collaboration, we are so happy to finally have this work published! @HastingsLab @CF_Foundation academic.oup.com/narmolmed/a…
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Stefan Rothenburg retweeted
My webinar on mpox and new vaccine development is Nov 26th @GlobalVirusNews @aaas @AmerSocVirol #mpox #vaccines @ASMicrobiology hstalks.com/webinar/5832/
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Stefan Rothenburg retweeted
📅 Join the Global Virus Network #webinar on November 26, 2024, with Dr. Tony Schountz, professor at Colorado State University! 🦇Topic: Jamaican Fruit #Bats as an Experimental Model for #Virology and Immunology ❗️ Register here: t.ly/0f6m- @GlobalVirusNews
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Stefan Rothenburg retweeted
Your hitchhiker's guide to microbiome studies: journals.asm.org/doi/epub/10…
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Stefan Rothenburg retweeted
31 Oct 2024
Are you a clinical trainee interested in undertaking a PhD in virology? 🩺🦠🧬🔬🧫 A 3-year Clinical PhD Fellowship available @CVRinfo Aug 2025 Programme details, inc current fellows: gla.ac.uk/research/az/cvr/tr… Apply: bmj.com/careers/job/210775/c… Closing date: 26 Nov 24 Pls share🙏
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Stefan Rothenburg retweeted
Thanks to my dear colleagues from Düsseldorf and Freiburg we were able to characterize a cluster of Mayaro #virus 🦠 infection in four members of a film crew during a stay in #Suriname 🇸🇷 . Please consider #Mayaro fever in the differential diagnosis of returning travelers from the Amazon basin with fever, rash and persistent arthralgia. #arbovirus @hans_kluge @Chikwe_I @WHO_Europe @pahowho eurosurveillance.org/content…
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(1/6) Our new paper is out (OA): Host species-specific activity of the poxvirus PKR inhibitors E3 and K3 mediate host range function | Journal of Virology journals.asm.org/doi/10.1128… It took 15 years from our initial discovery that human and mouse PKR were sensitive, whereas ...
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(5/6) Expression of different PKRs in congenic cells recapitulated the effects on vaccinia virus replication observed in species-derived cell lines during vaccinia virus replication. Expression of mutated Syrian hamster PKR even inhibited replication of wild type vaccinia virus.
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(6/6) These data support a model that suggests that E3 (and potentially dsRNA-binding proteins from other viruses), inhibits PKR by preventing functional PKR dimerization, and that dsRNA sequestration does not play a dominant role.
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