@RutenGroup profile picture
Andrew Rutenberg @RutenGroup

AC Fales Professor of Theoretical Physics @DalhousieU. Soft-matter and biological physics. Complex aging, collagen fibrils, single-file diffusion.

Joined December 2020
  • Tweets 136
  • Following 31
  • Followers 88
5 Photos and videos
Looking forward to our @thekingschorus concert this Saturday. “All the World's a Stage: A Concert of Popular Operatic and Stage Choruses” see facebook.com/events/96936043…
178
We just published a paper in Chaos on ”Network topologies for maximal organismal health span and lifespan”, see aip.scitation.org/doi/10.106… The upshot is that scale-free #networks (as previously assumed) are optimal. #aging #complexaging

1
2
190
Just published "Efficient representations of binarized health deficit data: the frailty index and beyond" in Geroscience: rdcu.be/c4jzt Glen Pridham used PCA on binarized deficit data and showed how the FI (and more) naturally emerges! #aging #geroscience #frailty
1
5
481
nytimes.com/2023/01/04/scien…

Asian Researchers Face Disparity With Key U.S. Science Funding Source (Gift Article)

White researchers fared best in winning grants from the National Science Foundation, a study says. Asians encounter the highest rate of rejections, challenging an academic stereotype.

nytimes.com
122
It felt good to study similar measures (#robustness and #resilience) in different organisms (#mice and #humans) during #aging It feels like we can learn the most from model organisms when we can do parallel studies with human data (or vice versa) doi.org/10.7554/eLife.77632

Measurements of damage and repair of binary health attributes in aging mice and humans reveal that...

Damage and repair for both aging mice and humans declined with age, exhibited very long timescales that varied across health attributes, and were differently affected by interventions.

elifesciences.org
1
4
556
We’ve just published a nice paper in eLife on #robustness and #resilience during #aging, using binarized data from mice and humans. Both robustness and resilience decline with age, but the timescales of action vary broadly over different health attributes. doi.org/10.7554/eLife.77632

Measurements of damage and repair of binary health attributes in aging mice and humans reveal that...

Damage and repair for both aging mice and humans declined with age, exhibited very long timescales that varied across health attributes, and were differently affected by interventions.

elifesciences.org
3
12
2,589
A real pleasure to be part of “A complex systems approach to aging biology” perspective nature.com/articles/s43587-0… led by Alan Cohen. More open longitudinal data will take veils away… #complexaging #quantitativeaging

A complex systems approach to aging biology

Nature Aging - The authors discuss how adopting a complex systems perspective is a crucial step in advancing our understanding of the aging process and requires fundamental alteration of the...

nature.com
2
In Canada it would be great to have this: “[CIHR] should explore the formation of [dedicated funding] devoted to biological physics”. nap.edu/read/26403/chapter/1 [300 pages] nationalacademies.org/news/2…

Paul Francois@p_r_francois
24 Mar 2022
Wow, this is fantastic. To be shared within all physics departments and beyond … nationalacademies.org/news/2…
1
Glad to see the #alliance (formerly ComputeCanada) up and running on Earth (and Canada)! alliancecan.ca starwars.fandom.com/wiki/All…

Digital Research Alliance of Canada

Powering Canadian innovation with digital research infrastructure. Access world-class computing, data management and res...

alliancecan.ca
ncl.ac.uk/futures/ageing-hea… Nice to see Newcastle recruiting at a senior level in #aginghealth. “This will require a multidisciplinary approach, drawing upon areas such as: •data science •artificial intelligence and machine learning •software engineering”
1
What #imputation is best for frailty imputation? MICE is good, but with CART rather than default. link.springer.com/article/10…
2
So in #aging with studies of #frailty, you should use good imputation if you want calibrated (comparable) measures of FI between studies, or between populations, or between individuals — essentially if you want to (as precisely as you can) compare FI.
1
The idea is that while ignoring missing data still lets the FI (a summary measure of aging health) predict well, the ignored values are (with ignore) replaced with the individual average. This leads to a bias (or inaccuracy).
1
Congrats to Glen Pridham (PhD student) who just published a paper on the importance of imputation for precise FI (Frailty Index) studies link.springer.com/article/10…
1
2
Spencer found doi.org/10.1371/journal.pcbi… that the interactions between health attributes are well-modelled as linear and time-independent. It will be interesting to see how far that generalizes to other types of data and organisms.
1
1
Joint models of #aging predict both health trajectories and mortality — both are needed to compare to large population studies. It is too easy to just get mortality (#Gompertz) right…
1
Glad to say our #ML #aging paper has just been published by PLOS Computational Biology doi.org/10.1371/journal.pcbi… We call it the DJIN model of aging (dynamic joint interpretable network model) Congratulations Spencer Farrell, who also just received a PhD from Dalhousie!
1
4
Congrats Ken Rockwood, for the Roman prize! dal.ca/news/2021/12/15/world… rymanhealthcare.co.nz/the-ry…

World‑leading geriatrician and anti‑ageism campaigner wins the Ryman Prize

Dr. Kenneth Rockwood is the seventh winner of the international health prize, which recognizes the best work carried out anywhere in the world that has enhanced quality of life for older people.

dal.ca
1
Nice paper discussing how DAGs (directed acyclic graphs) push variance around, and how this can distort causal discovery benchmarks but may be exploitable IRL if variables have the same natural units. #APaperADay arxiv.org/abs/2102.13647

Beware of the Simulated DAG! Causal Discovery Benchmarks May Be...

Simulated DAG models may exhibit properties that, perhaps inadvertently, render their structure identifiable and unexpectedly affect structure learning algorithms. Here, we show that marginal...

arxiv.org
1
3
6
Congrats to Spencer Farrell, who just graduated with a PhD! Currently looking for a post-doc… See researchgate.net/profile/Spe… or scholar.google.com/citations…

Spencer G. Farrell

Spencer FARRELL, Post doc | Cited by 506 | of University of Toronto, Toronto (U of T) | Read 38 publications | Contact Spencer FARRELL

researchgate.net
1
Load more