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Société de Chimie Thérapeutique @SCT_asso
Joined April 2015
  • Tweets 1,414
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  • Followers 627
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Société de Chimie Thérapeutique retweeted
MedBioChem@UniCA@MedBioChemUniCA
26 Feb 2024
💥3….2….1….. Here we go! 💥 From today you can send your applications to new Master 2 Chemistry @Univ_CotedAzur. 📆Important dates📆 February 26th to March 24th How to apply? 🧪 eCandidat/CampusFrance @NiceChemistry @PACA_SCF @reseauSCF @DCO_SCF @CNRS @CNRS_DR20 @SCT_asso
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Developments in the chemistry and biology of 1,2,3‐triazolyl‐C‐nucleosides - Nascimento - Archiv der Pharmazie - Wiley Online Library onlinelibrary.wiley.com/doi/…

Developments in the chemistry and biology of 1,2,3‐triazolyl‐C‐nucleosides

1,2,3-Triazolyl-C-nucleoside derivatives comprise a prolific and efficient subclass of ribavirin analogs. They are often prepared by the alkynylation of the  d-ribose ring followed by azide-alkyne...

onlinelibrary.wiley.com
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Regioselective and Stereoselective Synthesis of Parthenolide Analogs by Acyl Nitroso-Ene Reaction and Their Biological Evaluation against Mycobacterium tuberculosis mdpi.com/2597182 #mdpiijms via @IJMS_MDPI

Regioselective and Stereoselective Synthesis of Parthenolide Analogs by Acyl Nitroso-Ene Reaction...

Historically, natural products have played a major role in the development of antibiotics. Their complex chemical structures and high polarity give them advantages in the drug discovery process. In...

mdpi.com
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Discovery of a First-in-Class GPR183 Antagonist for the Potential Treatment of Rheumatoid Arthritis | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/acs…

Discovery of a First-in-Class GPR183 Antagonist for the Potential Treatment of Rheumatoid Arthritis

GPR183 is required for humoral immune responses, and its polymorphisms have been associated with inflammatory autoimmune diseases. Despite increasing attention to GPR183 as a potential therapeutic...

pubs.acs.org
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Société de Chimie Thérapeutique retweeted
Nature Reviews Drug Discovery@NatRevDrugDisc
4 Dec 2023
Our latest research highlight covers a paper in Nature Medicine reporting early-stage clinical data that indicates the potential for an IRAK4-targeted PROTAC to treat autoimmune skin diseases bit.ly/4a1dS5f
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Young Medicinal Chemistry Awards : 🏆🏆🏆 You work in drug discovery chemistry, medicinal chemistry, chemical biology or synthesis of bioactive compounds ? Check our website !!! From academia sct-asso.fr/ymc-academia-awa… From industry sct-asso.fr/ymc-industry-awa…
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Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/acs…

Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of...

The discovery of chiral amino alcohols derived from our previously disclosed clinical LTA4H inhibitor LYS006 is described. In a biochemical assay, their optical antipodes showed similar potencies,...

pubs.acs.org
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A Novel Bifunctional μOR Agonist and σ1R Antagonist with Potent Analgesic Responses and Reduced Adverse Effects | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/acs…

A Novel Bifunctional μOR Agonist and σ1R Antagonist with Potent Analgesic Responses and Reduced...

Bifunctional ligands possessing both μOR agonism and σ1R antagonism have shown promise in producing strong analgesic effects with reduced opioid-related side effects. However, the μOR agonism...

pubs.acs.org
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Discovery of imidazo[1,2-b]pyridazine-containing TAK1 kinase inhibitors with excellent activities against multiple myeloma - now published in RSC Medicinal Chemistry pubs.rsc.org/en/content/arti…

Discovery of imidazo[1,2-b]pyridazine-containing TAK1 kinase inhibitors with excellent activities...

Current treatment options for patients with multiple myeloma (MM) include proteasome inhibitors, anti-CD38 antibodies, and immunomodulatory agents. However, if patients have continued disease...

pubs.rsc.org
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Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/acs…

Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library...

WD40 repeat-containing protein 91 (WDR91) regulates early-to-late endosome conversion and plays vital roles in endosome fusion, recycling, and transport. WDR91 was recently identified as a potential...

pubs.acs.org
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Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2) | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/acs…

Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin...

CaMKK2 signals through AMPK-dependent and AMPK-independent pathways to trigger cellular outputs including proliferation, differentiation, and migration, resulting in changes to metabolism, bone mass...

pubs.acs.org
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Molecular basis of opioid receptor signaling: Cell cell.com/cell/fulltext/S0092…
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Characterization of 2,4-Dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3, PfNEK3, PfPK9, and PfPKB | ACS Medicinal Chemistry Letters pubs.acs.org/doi/10.1021/acs…

Characterization of 2,4-Dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3,...

Plasmodium kinases are increasingly recognized as potential novel antiplasmodial targets for the treatment of malaria, but only a small subset of these kinases have had structure–activity relations...

pubs.acs.org
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Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling | ACS Chemical Biology pubs.acs.org/doi/10.1021/acs…

Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling

Molecular glue degraders (MGDs) are small molecules that degrade proteins of interest via the ubiquitin–proteasome system. While MGDs were historically discovered serendipitously, approaches for MGD...

pubs.acs.org
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Open Postdoc position in #ChemicalBiology @uni_nice from January 2024. #MedChemJob #BiologyJobApplication @YoungSciNet @YoungChemists @SCT_YMCF @EuroMedChem @SCIYoungChem
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Synthetic Approaches to the New Drugs Approved During 2021 |👌 Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/acs…

Synthetic Approaches to the New Drugs Approved During 2021

Each year, new drugs are introduced to the market, representing structures that have affinity for biological targets implicated in human diseases and conditions. These new chemical entities (NCEs),...

pubs.acs.org
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Discovery of ERD-3111 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader with Strong Antitumor Activity | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/acs…

Discovery of ERD-3111 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader with...

Estrogen receptor α (ERα) is a prime target for the treatment of ER-positive (ER ) breast cancer. Despite the development of several effective therapies targeting ERα signaling, clinical resistance...

pubs.acs.org
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Société de Chimie Thérapeutique retweeted
Boris Vauzeilles@BorisVauzeilles
25 Sep 2023
We are very excited to host @RentmeisterLab for the upcoming #ChemBio2024 symposium in Paris Saclay, Jan 24-26, 2024. Register here: scf-chembio2024.com – Early bird deadline is Oct 15 - discounted rates for @SCF_ChemBio @EuChemS @EuroMedChem - @reseauSCF #ChemBio
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Discovery of Triazinone Derivatives as Novel, Specific, and Direct NLRP3 Inflammasome Inhibitors for the Treatment of DSS-Induced Ulcerative Colitis | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/acs…

Discovery of Triazinone Derivatives as Novel, Specific, and Direct NLRP3 Inflammasome Inhibitors...

NLRP3 is an intracellular sensor protein that causes inflammasome formation and pyroptosis in response to a wide range of stimuli. Aberrant activation of NLRP3 inflammasome has been implicated in...

pubs.acs.org
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RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET | ACS Chemical Biology pubs.acs.org/doi/10.1021/acs…

RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime...

Hyperactivity of cardiac sarcoplasmic reticulum (SR) ryanodine receptor (RyR2) Ca2 -release channels contributes to heart failure and arrhythmias. Reducing the RyR2 activity, particularly during...

pubs.acs.org
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