Joined July 2024
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GPT-5 showed no clinical superiority over previous models, despite launch claims, highlighting ongoing risks to patient safety and privacy.
link.springer.com/article/10ā¦
@OpenAI @sama @miramurati @EricTopol @rohanpaul_ai @DeryaTR_ @deedydas @agingdoc1 @strnr @rmh199 @tmboussard
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Inhibiting macropinocytosis may offer a novel therapeutic avenue to combat pulmonary fibrosis by reducing profibrotic responses in lung cells.
by Rosas IO, McDowell-Sanchez AK (...) Tsoyi K et 11 al. in J Clin Invest
jci.org/articles/view/197651 #MedX #MedResearch
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Targeting fatty acid oxidation linked to KRAS inhibition offers a promising therapeutic strategy to combat pancreatic cancer's metabolic vulnerabilities.
by Thakur R, Wang D (...) Singh PK et 19 al. in Cancer Res
aacrjournals.org/cancerres/aā¦ #MedX #MedResearch
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Cumulative lead exposure drives significant cardiovascular mortality, contributing to 3.5 million deaths and 71.6 million DALYs globally in 2023.
by None None, Stanaway JD (...) Brauer M et 9 al. in JAMA
jamanetwork.com/journals/jamā¦ #MedX #MedResearch
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Targeting TRIM28 offers new hope for reducing ferroptosis and preventing myocardial injury post-ischemia/reperfusion in heart disease patients.
by Zhu K, Guo J (...) Cao CM et 19 al. in Circulation
ahajournals.org/doi/10.1161/ā¦ #MedX #MedResearch
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Anti-nephrin autoantibodies rarely occur in podocytopathies, challenging their role as specific biomarkers in kidney diseases.
by Pecoraro F, Perico L (...) Remuzzi G et 11 al. in J Clin Invest
jci.org/articles/view/204727 #MedX #MedResearch
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Iron overload in steatotic liver cells disrupts metabolism by altering hepatokine production, but targeted therapies show potential for reversal.
by Jo HJ, Kim A (...) Han CY et 24 al. in J Clin Invest
jci.org/articles/view/196374 #MedX #MedResearch
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Cardiac resynchronization therapy significantly reduces all-cause mortality and heart failure hospitalizations in patients with systolic dysfunction and dyssynchrony.
by Ternes CM, Kim JA (...) Chelu MG et 2 al. in JAMA
jamanetwork.com/journals/jamā¦ #MedX #MedResearch
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Chronic pancreatitis demands a shift toward early intervention and patient-tailored therapies to modify disease progression and manage inflammation.
by Mahapatra SJ, Dhar Chowdhury S, Akshintala VS and Garg PK in Gastroenterology
linkinghub.elsevier.com/retrā¦ #MedX #MedResearch
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Bardet-Biedl syndrome in children reveals high rates of obesity and short stature, but low prevalence of endocrine disorders.
by Varughese RS, Pujari D (...) Chesover AD et 12 al. in J Clin Endocrinol Metab
academic.oup.com/jcem/advancā¦ #MedX #MedResearch
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Families Face Steep Premium Hikes After ACA Enhanced Tax Credits Expire, Burdening Lower-Income Households Significantly.
by Goldstein Novick NP, Formanowski B (...) Salazar EG et 4 al. in Pediatrics
publications.aap.org/pediatrā¦ #MedX #MedResearch
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New AMOCO Method Transforms Ungated Hepatic 4D Flow MRI, Enhancing Image Quality and Flow Measurement Consistency Without Extended Scan Times
by Cao R, Li S (...) Li H et 12 al. in Magn Reson Med
onlinelibrary.wiley.com/doi/ā¦ #MedX #MedResearch
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Dystonia severity links to brain volume changes and NAD levels, unveiling metabolic differences in GCH1 mutation carriers.
by Prasuhn J, van Well L (...) BrĆ¼ggemann N et 10 al. in Mov Disord
movementdisorders.onlinelibrā¦ #MedX #MedResearch
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Monoclonal antibody L9LS offers 42.7% malaria protection in young Kenyan children, demonstrating safety and potential for further efficacy enhancements.
by Steinhardt LC, Kwambai TK (...) Seder RA et 25 al. in Lancet
thelancet.com/journals/lanceā¦ #MedX #MedResearch
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Study reveals skipping defibrillation testing during subcutaneous ICD implantation, guided by the PRAETORIAN score, maintains shock efficacy while reducing risks.
by Knops RE, Marquie C (...) El-Chami MF et 44 al. in Circulation
ahajournals.org/doi/10.1161/ā¦ #MedX #MedResearch
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Pediatric subspecialists' lifetime earnings gap against adults has widened from 15.7% in 2014 to 20.2% in 2024, threatening workforce sustainability.
by Gadiwala S, Shukla A (...) Daily J et 3 al. in Pediatrics
publications.aap.org/pediatrā¦ #MedX #MedResearch
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TREX1's unique dsDNA-binding architecture modulates cGAS-STING signaling, highlighting its role in autoimmune responses and potential cancer immunity.
by Zhu J, Wang L (...) Zhou W et 5 al. in Immunity
sciencedirect.com/science/arā¦ #MedX #MedResearch
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Transdermal estradiol patches demonstrate noninferior metastasis-free survival compared to LHRH agonists, with fewer hot flashes but more gynecomastia.
by Langley RE, Gilbert DC (...) Nankivell M et 49 al. in N Engl J Med
nejm.org/doi/10.1056/NEJMoa2ā¦ #MedX #MedResearch
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MplW514L mutation drives essential thrombocythemia and myelofibrosis in mice, revealing targeted therapy limitations against disease-initiating stem cells.
by Zhang S, Liu J (...) Zhao B et 9 al. in J Clin Invest
jci.org/articles/view/199690 #MedX #MedResearch
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Ciliated cells in the fallopian tube are pivotal guardians against DNA damage, critical for preventing high-grade serous carcinoma initiation.
by Colina JA, Recouvreux MS (...) DiFeo A et 28 al. in Cancer Res
aacrjournals.org/cancerres/aā¦ #MedX #MedResearch
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Focal coronary artery disease significantly enhances symptom relief from PCI, outperforming diffuse disease in improving angina and exercise capacity.
by Chiew K, Foley MJ (...) Al-Lamee RK et 14 al. in J Am Coll Cardiol
sciencedirect.com/science/arā¦ #MedX #MedResearch
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