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Pabi Sahoo (ପବିତ୍ର ସାହୁ) @SahooLab

Assistant Professor at Rutgers University | Molecular Neurobiologist | Neural repair | Neurodevelopment

Joined June 2018
  • Tweets 528
  • Following 552
  • Followers 418
41 Photos and videos
Our CNS regeneration work is now online. Terrific postdocs @manasiagrawal1 and @meghaldesai completed the revision experiments. @RutgersSASN @RutgersU pnas.org/doi/10.1073/pnas.24…

Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration | PNAS

Depletion or inhibition of core stress granule proteins, G3BP1 in mammals and TIAR-2 in Caenorhabditis elegans, increases the growth of spontaneous...

pnas.org
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Read this exciting work from the @KristyWelshhans lab led by @manasiagrawal1. Very happy to have contributed to this story.
Brain@Brain1878
Jun 12
Using human and mouse models of Down syndrome, Agrawal et al. show that overexpression of the chromosome 21 gene DSCAM disrupts neuronal development and axon guidance, leading to altered neural connectivity and contributing to learning impairments. shorturl.at/dOkVJ
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Stress granules restrain ferroptosis by sequestering ferritin | Nature Cell Biology nature.com/articles/s41556-0…

Stress granules restrain ferroptosis by sequestering ferritin

Nature Cell Biology - Ge, Wang, Zhao, Guo et al. report a role for stress granules in suppressing ferroptosis by sequestering ferritin upon irradiation and temozolomide treatment in glioblastoma...

nature.com
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First major grant for the lab. Thank you, #NJCBIR, for believing in us. Now let's get back to the bench to get that work done :)
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Pabi Sahoo (ପବିତ୍ର ସାହୁ) retweeted
Manasi Agrawal, Ph.D.@manasiagrawal1
Apr 8
This review was a great opportunity to take a step back and appreciate the progress in iPSC-based models for neural repair. But can we truly model human neural repair? Excited to share our review that discusses how far we’ve come in the field while highlighting what’s missing!
Pabi Sahoo (ପବିତ୍ର ସାହୁ)@SahooLab
Mar 21
There is a current push towards doing biological research using only hiPSC models, but are we there yet? @manasiagrawal1 nicely discusses it in this review using neural repair as a model system. sciencedirect.com/science/ar…
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Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation | EMBO Reports | Springer Nature Link link.springer.com/article/10…

Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local...

EMBO Reports - Ribonucleoprotein (RNP) granules are dynamic, membraneless organelles that sequester translationally repressed mRNAs and RNA-binding proteins, playing a pivotal role in the...

link.springer.com
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Pabi Sahoo (ପବିତ୍ର ସାହୁ) retweeted
Rutgers University@RutgersU
Mar 26
Congratulations to 8 Rutgers researchers named fellows of the prestigious American Association for the Advancement of Science. rutgers.edu/news/eight-resea…
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How many axon localization elements are in one mRNA? mTor mRNA seems to have at least 3. Read this interesting preprint from the Fainzilber lab. Multiple mTOR RNA localization signals regulate subcellular protein synthesis and axonal growth biorxiv.org/content/10.64898…
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There is a current push towards doing biological research using only hiPSC models, but are we there yet? @manasiagrawal1 nicely discusses it in this review using neural repair as a model system. sciencedirect.com/science/ar…
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Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science science.org/doi/abs/10.1126/…

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes

Cells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the...

science.org
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So it was an RNA world 🤔. A small polymerase ribozyme that can synthesize itself and its complementary strand | Science science.org/doi/10.1126/scie…

A small polymerase ribozyme that can synthesize itself and its complementary strand

The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural...

science.org
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Our methods paper is now online. It was co-led by Shruti Ghumra and @manasiagrawal1. If you are struggling with enriched axonal preparations, you may find this paper useful! JoVE jove.com/t/69601

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Here is the preview video!
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It was exciting to introduce our lab and work to the Rutgers Neuroscience community. @meghal_desai @manasiagrawal1 did an amazing job! @BHI_Rutgers
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TRIM28-mediated SUMOylation of G3BP1/2 regulates stress granule dynamics: Cell Chemical Biology cell.com/cell-chemical-biolo…

TRIM28-mediated SUMOylation of G3BP1/2 regulates stress granule dynamics

Yuan et al. identify TRIM28 as a key component of stress granules (SGs) using the lcFAX-MS approach established here and define TRIM28-mediated G3BP1/2 SUMOylation as a critical mechanism regulating...

cell.com
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KIF5A binds RNA to orchestrate synaptic mRNA localization and stress granules in ALS | bioRxiv biorxiv.org/content/10.1101/…

KIF5A binds RNA to orchestrate synaptic mRNA localization and stress granules in ALS

Neuronal health depends on the precise transport and local translation of mRNAs to maintain synaptic function across highly polarized cellular architecture. While kinesin motor proteins are known to...

biorxiv.org
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Super cool results from the ⁦⁦@jltwiss1⁩ lab. ⁩ Source: bioRxiv share.google/Y0THivY7gyNnNKy…
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Read this excellent story from the @jltwiss1 lab. Acetylation of Axonal G3BP1 through ELP3 Accelerates Axon Regeneration biorxiv.org/content/10.1101/…

Acetylation of Axonal G3BP1 through ELP3 Accelerates Axon Regeneration

Nerve injury triggers localized translation of axonal mRNAs to respond to injury and nerve regeneration. The core stress granule protein G3BP1 sequesters axonal mRNAs in granules before and after...

biorxiv.org
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Pabi Sahoo (ପବିତ୍ର ସାହୁ) retweeted
Perlson lab@LabPerlson
5 Oct 2025
Thrilled to share our new work in Nature Neuroscience! Together with amazing collaborators and led by Ariel Ionescu, we discovered that muscle-derived miR-126 controls local axonal TDP-43 synthesis and protects neuromuscular junctions in ALS. nature.com/articles/s41593-0…

Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models

Nature Neuroscience - Ionescu, Ankol et al. show that, in ALS mouse and iPSC models, TDP-43 aggregation at NMJs stems from aberrant axonal translation, normally repressed by muscle EV-derived...

nature.com
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Meghal and Shruti received the BHI travel award. Congratulations both! brainhealthinstitute.rutgers…

Congratulations to the 2025-2026 BHI Trainee Travel Award Winners! - BHI

brainhealthinstitute.rutgers.edu
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Super cool results from the Vande Velde lab. TDP-43 pathology triggers SRRM4-dependent cryptic splicing of G3BP1 in ALS/FTD biorxiv.org/content/10.1101/…

TDP-43 pathology triggers SRRM4-dependent cryptic splicing of G3BP1 in ALS/FTD

Loss of nuclear TDP-43 is a defining feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), yet how this leads to selective neuronal vulner...

biorxiv.org
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